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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40362

FusionGeneSummary for UBAP2_FAM171A1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBAP2_FAM171A1
Fusion gene ID: 40362
HgeneTgene
Gene symbol

UBAP2

FAM171A1

Gene ID

55833

221061

Gene nameubiquitin associated protein 2family with sequence similarity 171 member A1
SynonymsUBAP-2C10orf38
Cytomap

9p13.3

10p13

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-associated protein 2AD-012 proteinprotein FAM171A1astroprincin
Modification date2018052320180519
UniProtAcc

Q5T6F2

Q5VUB5

Ensembl transtripts involved in fusion geneENST00000449054, ENST00000379238, 
ENST00000360802, ENST00000379239, 
ENST00000539807, ENST00000418786, 
ENST00000379225, ENST00000379235, 
ENST00000480885, 
ENST00000378116, 
ENST00000477161, 
Fusion gene scores* DoF score13 X 10 X 8=10403 X 3 X 3=27
# samples 133
** MAII scorelog2(13/1040*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBAP2 [Title/Abstract] AND FAM171A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0T0-01AUBAP2chr9

34048823

-FAM171A1chr10

15326104

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000449054ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-intronENST00000449054ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-3CDSENST00000379238ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-intronENST00000379238ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
intron-3CDSENST00000360802ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
intron-intronENST00000360802ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-3CDSENST00000379239ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-intronENST00000379239ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-3CDSENST00000539807ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-intronENST00000539807ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
intron-3CDSENST00000418786ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
intron-intronENST00000418786ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
intron-3CDSENST00000379225ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
intron-intronENST00000379225ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
intron-3CDSENST00000379235ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
intron-intronENST00000379235ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-3CDSENST00000480885ENST00000378116UBAP2chr9

34048823

-FAM171A1chr10

15326104

-
5UTR-intronENST00000480885ENST00000477161UBAP2chr9

34048823

-FAM171A1chr10

15326104

-

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FusionProtFeatures for UBAP2_FAM171A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBAP2

Q5T6F2

FAM171A1

Q5VUB5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBAP2_FAM171A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBAP2_FAM171A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBAP2G3BP2, CUL3, UBAP2L, DLD, NUP50, VDAC1, TOMM40, PRDX5, ZFR, VPS29, THY1, S100A10, ZC3H14, ITCH, WWOX, FXR1, FUS, KLHL20, GLUL, QPCT, RBFOX2, CDKL5, NTRK1, CDH1, HSPBP1, HAO2, GORASP2, RAVER1, SCYL2, TRIM25, G3BP1, BRCA1FAM171A1NTRK1, TMEM17, CTDSPL, FAM171B, PCDHGB1, TNFRSF17


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBAP2_FAM171A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBAP2_FAM171A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneUBAP2C0001973Alcoholic Intoxication, Chronic1PSYGENET