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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40351

FusionGeneSummary for UBAP1_UBAP1

check button Fusion gene summary
Fusion gene informationFusion gene name: UBAP1_UBAP1
Fusion gene ID: 40351
HgeneTgene
Gene symbol

UBAP1

UBAP1

Gene ID

51271

51271

Gene nameubiquitin associated protein 1ubiquitin associated protein 1
SynonymsNAG20|UAP|UBAP|UBAP-1NAG20|UAP|UBAP|UBAP-1
Cytomap

9p13.3

9p13.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-associated protein 1nasopharyngeal carcinoma-associated gene 20 proteinubiquitin-associated protein 1nasopharyngeal carcinoma-associated gene 20 protein
Modification date2018052320180523
UniProtAcc

Q9NZ09

Q9NZ09

Ensembl transtripts involved in fusion geneENST00000536252, ENST00000545103, 
ENST00000540348, ENST00000543944, 
ENST00000297661, ENST00000379186, 
ENST00000359544, 		ENST00000536252, 
ENST00000545103, ENST00000540348, 
ENST00000543944, ENST00000297661, 
ENST00000379186, ENST00000359544, 
Fusion gene scores* DoF score5 X 5 X 5=1258 X 8 X 4=256
# samples 69
** MAII scorelog2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: UBAP1 [Title/Abstract] AND UBAP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW891794UBAP1chr9

34218049

+UBAP1chr9

34217441

+
ChiTaRS3.1CA314663UBAP1chr9

34252385

-UBAP1chr9

34252094

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000536252ENST00000536252UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000536252ENST00000545103UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000536252ENST00000540348UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000536252ENST00000543944UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000536252ENST00000297661UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000536252ENST00000379186UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000536252ENST00000359544UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000545103ENST00000536252UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000545103ENST00000545103UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000545103ENST00000540348UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000545103ENST00000543944UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000545103ENST00000297661UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000545103ENST00000379186UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000545103ENST00000359544UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000540348ENST00000536252UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000540348ENST00000545103UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000540348ENST00000540348UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000540348ENST00000543944UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000540348ENST00000297661UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000540348ENST00000379186UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000540348ENST00000359544UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000543944ENST00000536252UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000543944ENST00000545103UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000543944ENST00000540348UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000543944ENST00000543944UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000543944ENST00000297661UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000543944ENST00000379186UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000543944ENST00000359544UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000297661ENST00000536252UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000297661ENST00000545103UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000297661ENST00000540348UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000297661ENST00000543944UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000297661ENST00000297661UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000297661ENST00000379186UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000297661ENST00000359544UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000379186ENST00000536252UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000379186ENST00000545103UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000379186ENST00000540348UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000379186ENST00000543944UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000379186ENST00000297661UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000379186ENST00000379186UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000379186ENST00000359544UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000359544ENST00000536252UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000359544ENST00000545103UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000359544ENST00000540348UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000359544ENST00000543944UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000359544ENST00000297661UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000359544ENST00000379186UBAP1chr9

34218049

+UBAP1chr9

34217441

+
intron-intronENST00000359544ENST00000359544UBAP1chr9

34218049

+UBAP1chr9

34217441

+
3UTR-3UTRENST00000536252ENST00000536252UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000536252ENST00000545103UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000536252ENST00000540348UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000536252ENST00000543944UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000536252ENST00000297661UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000536252ENST00000379186UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000536252ENST00000359544UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000545103ENST00000536252UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000545103ENST00000545103UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000545103ENST00000540348UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000545103ENST00000543944UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000545103ENST00000297661UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000545103ENST00000379186UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000545103ENST00000359544UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000540348ENST00000536252UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000540348ENST00000545103UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000540348ENST00000540348UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000540348ENST00000543944UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000540348ENST00000297661UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000540348ENST00000379186UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000540348ENST00000359544UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000543944ENST00000536252UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000543944ENST00000545103UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000543944ENST00000540348UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000543944ENST00000543944UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000543944ENST00000297661UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000543944ENST00000379186UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000543944ENST00000359544UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000297661ENST00000536252UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000297661ENST00000545103UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000297661ENST00000540348UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000297661ENST00000543944UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000297661ENST00000297661UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000297661ENST00000379186UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000297661ENST00000359544UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000379186ENST00000536252UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000379186ENST00000545103UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000379186ENST00000540348UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000379186ENST00000543944UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000379186ENST00000297661UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000379186ENST00000379186UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000379186ENST00000359544UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000359544ENST00000536252UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000359544ENST00000545103UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000359544ENST00000540348UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000359544ENST00000543944UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000359544ENST00000297661UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000359544ENST00000379186UBAP1chr9

34252385

-UBAP1chr9

34252094

+
3UTR-3UTRENST00000359544ENST00000359544UBAP1chr9

34252385

-UBAP1chr9

34252094

+

Top

FusionProtFeatures for UBAP1_UBAP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBAP1

Q9NZ09

UBAP1

Q9NZ09


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBAP1_UBAP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBAP1_UBAP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBAP1_UBAP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBAP1_UBAP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource