FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 40339

FusionGeneSummary for UBAC2_ASNS

check button Fusion gene summary
Fusion gene informationFusion gene name: UBAC2_ASNS
Fusion gene ID: 40339
HgeneTgene
Gene symbol

UBAC2

ASNS

Gene ID

337867

440

Gene nameUBA domain containing 2asparagine synthetase (glutamine-hydrolyzing)
SynonymsPHGDHL1ASNSD|TS11
Cytomap

13q32.3

7q21.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-associated domain-containing protein 2RP11-178C10.1UBA domain-containing protein 2phosphoglycerate dehydrogenase like 1phosphoglycerate dehydrogenase-like protein 1asparagine synthetase [glutamine-hydrolyzing]TS11 cell cycle control proteinglutamine-dependent asparagine synthetase
Modification date2018051920180523
UniProtAcc

Q8NBM4

P08243

Ensembl transtripts involved in fusion geneENST00000403766, ENST00000376440, 
ENST00000460562, 
ENST00000175506, 
ENST00000394309, ENST00000437628, 
ENST00000394308, ENST00000422745, 
ENST00000455086, ENST00000444334, 
Fusion gene scores* DoF score5 X 6 X 5=1501 X 2 X 1=2
# samples 91
** MAII scorelog2(9/150*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/2*10)=2.32192809488736
Context

PubMed: UBAC2 [Title/Abstract] AND ASNS [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneUBAC2

GO:0070972

protein localization to endoplasmic reticulum

23297223

TgeneASNS

GO:0006529

asparagine biosynthetic process

2573597

TgeneASNS

GO:0042149

cellular response to glucose starvation

10085239

TgeneASNS

GO:0045931

positive regulation of mitotic cell cycle

2569668


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-G3-A7M9-01AUBAC2chr13

99896878

+ASNSchr7

97499125

-
TCGALDLIHCTCGA-G3-A7M9-01AUBAC2chr13

99896878

+ASNSchr7

97498491

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000403766ENST00000175506UBAC2chr13

99896878

+ASNSchr7

97499125

-
5CDS-5UTRENST00000403766ENST00000394309UBAC2chr13

99896878

+ASNSchr7

97499125

-
5CDS-intronENST00000403766ENST00000437628UBAC2chr13

99896878

+ASNSchr7

97499125

-
5CDS-5UTRENST00000403766ENST00000394308UBAC2chr13

99896878

+ASNSchr7

97499125

-
5CDS-intronENST00000403766ENST00000422745UBAC2chr13

99896878

+ASNSchr7

97499125

-
5CDS-intronENST00000403766ENST00000455086UBAC2chr13

99896878

+ASNSchr7

97499125

-
5CDS-5UTRENST00000403766ENST00000444334UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-5UTRENST00000376440ENST00000175506UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-5UTRENST00000376440ENST00000394309UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-intronENST00000376440ENST00000437628UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-5UTRENST00000376440ENST00000394308UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-intronENST00000376440ENST00000422745UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-intronENST00000376440ENST00000455086UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-5UTRENST00000376440ENST00000444334UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-5UTRENST00000460562ENST00000175506UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-5UTRENST00000460562ENST00000394309UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-intronENST00000460562ENST00000437628UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-5UTRENST00000460562ENST00000394308UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-intronENST00000460562ENST00000422745UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-intronENST00000460562ENST00000455086UBAC2chr13

99896878

+ASNSchr7

97499125

-
intron-5UTRENST00000460562ENST00000444334UBAC2chr13

99896878

+ASNSchr7

97499125

-
5CDS-5UTRENST00000403766ENST00000175506UBAC2chr13

99896878

+ASNSchr7

97498491

-
5CDS-5UTRENST00000403766ENST00000394309UBAC2chr13

99896878

+ASNSchr7

97498491

-
5CDS-intronENST00000403766ENST00000437628UBAC2chr13

99896878

+ASNSchr7

97498491

-
5CDS-5UTRENST00000403766ENST00000394308UBAC2chr13

99896878

+ASNSchr7

97498491

-
5CDS-intronENST00000403766ENST00000422745UBAC2chr13

99896878

+ASNSchr7

97498491

-
5CDS-intronENST00000403766ENST00000455086UBAC2chr13

99896878

+ASNSchr7

97498491

-
5CDS-intronENST00000403766ENST00000444334UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-5UTRENST00000376440ENST00000175506UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-5UTRENST00000376440ENST00000394309UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-intronENST00000376440ENST00000437628UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-5UTRENST00000376440ENST00000394308UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-intronENST00000376440ENST00000422745UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-intronENST00000376440ENST00000455086UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-intronENST00000376440ENST00000444334UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-5UTRENST00000460562ENST00000175506UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-5UTRENST00000460562ENST00000394309UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-intronENST00000460562ENST00000437628UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-5UTRENST00000460562ENST00000394308UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-intronENST00000460562ENST00000422745UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-intronENST00000460562ENST00000455086UBAC2chr13

99896878

+ASNSchr7

97498491

-
intron-intronENST00000460562ENST00000444334UBAC2chr13

99896878

+ASNSchr7

97498491

-

Top

FusionProtFeatures for UBAC2_ASNS


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBAC2

Q8NBM4

ASNS

P08243


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for UBAC2_ASNS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for UBAC2_ASNS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
UBAC2MME, FAF2, TSR1, NONO, ATP6V1C1, CALCOCO2, AMFR, TUBA8, TUBB7P, VDAC1, HNRNPM, TBC1D15, ANK2, EMD, RAB7A, RPL10, HM13, EMC2, KMT2D, ERLIN2, TMED9, TUBA1A, GCN1L1, ERLIN1, EMC3, PEX19, TMEM43, CLPTM1, TMEM201, EMC1, LRRC59, RPN2, SEC22B, VAPA, TOMM40, PRKDC, SURF4, RAB35, TBC1D17, ACTA1, CAND1, UBC, KLK7, S100A16, CPA4, PCYOX1, HAL, KPRP, KRAS, STK17B, BAG3, ATP6AP2, GOLT1B, SYVN1, UFD1L, NPLOC4, DUSP9, SLC17A2, TTC30BASNSSTRN4, ATG101, DDA1, PRKAG2, SIRT7, CDK2, COPS5, DCUN1D1, IARS, AARS, GARS, EPRS, KYNU, ATXN1, VCAM1, ITGA4, ALDH7A1, CAPN2, DCPS, ISOC1, MSN, STK26, MYO1E, OGFOD1, OLA1, PAFAH1B1, PDIA4, PTMA, STK24, TBCB, TWF2, VCL, CAPNS1, GSS, PAPSS1, PPP1CA, PROSC, RAP1GDS1, SCPEP1, SH2D4A, YWHAE, TRIM69, WDR27, EGFR, ABCE1, FAM78A, AHNAK, AHSA1, FASN, GALE, GFPT1, LYPLA1, MAT2A, PAICS, PEBP1, PHGDH, SOD1, UBQLN1, UBQLN4, UFD1L, ASS1, CBS, CD2AP, COASY, CSTF1, GDA, GLRX, HSPBP1, LARS, MAPK3, NMD3, NPLOC4, NUP50, PXN, QARS, RRM2, TRAP1, TTC27, UBA1, XPNPEP1, NTRK1, OTUB1, SDHA, TRIM25, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for UBAC2_ASNS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneASNSP08243DB00142Glutamic AcidAsparagine synthetase [glutamine-hydrolyzing]small moleculeapproved|nutraceutical

Top

RelatedDiseases for UBAC2_ASNS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneASNSC0023794Lipoidosis1CTD_human
TgeneASNSC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneASNSC3809971ASPARAGINE SYNTHETASE DEFICIENCY1ORPHANET;UNIPROT