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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40330

FusionGeneSummary for UBA52_VPS28

check button Fusion gene summary
Fusion gene informationFusion gene name: UBA52_VPS28
Fusion gene ID: 40330
HgeneTgene
Gene symbol

UBA52

VPS28

Gene ID

7311

51160

Gene nameubiquitin A-52 residue ribosomal protein fusion product 1VPS28, ESCRT-I subunit
SynonymsCEP52|HUBCEP52|L40|RPL40-
Cytomap

19p13.11

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionubiquitin-60S ribosomal protein L40ubiquitin carboxyl extension protein 52ubiquitin-52 amino acid fusion proteinubiquitin-CEP52vacuolar protein sorting-associated protein 28 homologESCRT-I complex subunit VPS28vacuolar protein sorting 28 homologvacuolar protein sorting 28-like proteinyeast class E protein Vps28p homolog
Modification date2018052320180523
UniProtAcc

P62987

Q9UK41

Ensembl transtripts involved in fusion geneENST00000596304, ENST00000430157, 
ENST00000596273, ENST00000442744, 
ENST00000595683, ENST00000595158, 
ENST00000598780, ENST00000599551, 
ENST00000597451, ENST00000599595, 
ENST00000526054, ENST00000529182, 
ENST00000377348, ENST00000292510, 
ENST00000526734, 
Fusion gene scores* DoF score15 X 13 X 3=5854 X 4 X 2=32
# samples 174
** MAII scorelog2(17/585*10)=-1.78290187833307
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: UBA52 [Title/Abstract] AND VPS28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVPS28

GO:0031397

negative regulation of protein ubiquitination

18077552


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG482364UBA52chr19

18685733

-VPS28chr8

145649367

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000596304ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596304ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596304ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596304ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596304ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000430157ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000430157ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000430157ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000430157ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000430157ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596273ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596273ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596273ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596273ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000596273ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000442744ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000442744ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000442744ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000442744ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000442744ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595683ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595683ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595683ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595683ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595683ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595158ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595158ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595158ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595158ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000595158ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000598780ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000598780ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000598780ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000598780ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000598780ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599551ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599551ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599551ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599551ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599551ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000597451ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000597451ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000597451ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000597451ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000597451ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599595ENST00000526054UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599595ENST00000529182UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599595ENST00000377348UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599595ENST00000292510UBA52chr19

18685733

-VPS28chr8

145649367

-
5CDS-intronENST00000599595ENST00000526734UBA52chr19

18685733

-VPS28chr8

145649367

-

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FusionProtFeatures for UBA52_VPS28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
UBA52

P62987

VPS28

Q9UK41

Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. {ECO:0000269|PubMed:11916981}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for UBA52_VPS28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for UBA52_VPS28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for UBA52_VPS28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for UBA52_VPS28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource