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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4026

FusionGeneSummary for BCL2L13_ZNF383

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL2L13_ZNF383
Fusion gene ID: 4026
HgeneTgene
Gene symbol

BCL2L13

ZNF383

Gene ID

23786

163087

Gene nameBCL2 like 13zinc finger protein 383
SynonymsBCL-RAMBO|Bcl2-L-13|MIL1HSD17
Cytomap

22q11.21

19q13.12

Type of geneprotein-codingprotein-coding
Descriptionbcl-2-like protein 13BCL2-like 13 (apoptosis facilitator)zinc finger protein 383
Modification date2018052320180519
UniProtAcc

Q9BXK5

Q8NA42

Ensembl transtripts involved in fusion geneENST00000399782, ENST00000317582, 
ENST00000543133, ENST00000538149, 
ENST00000337612, ENST00000493680, 
ENST00000355028, ENST00000418951, 
ENST00000485631, 
ENST00000585441, 
ENST00000590503, ENST00000589413, 
ENST00000352998, 
Fusion gene scores* DoF score8 X 7 X 7=3923 X 2 X 3=18
# samples 93
** MAII scorelog2(9/392*10)=-2.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BCL2L13 [Title/Abstract] AND ZNF383 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-DK-A1A3-01ABCL2L13chr22

18185152

+ZNF383chr19

37733371

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000399782ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000399782ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000399782ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000399782ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000317582ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000317582ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000317582ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000317582ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000543133ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000543133ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000543133ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000543133ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000538149ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000538149ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000538149ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000538149ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000337612ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000337612ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000337612ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000337612ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000493680ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000493680ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000493680ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
5CDS-intronENST00000493680ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000355028ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000355028ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000355028ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000355028ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000418951ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000418951ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000418951ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000418951ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000485631ENST00000585441BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000485631ENST00000590503BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000485631ENST00000589413BCL2L13chr22

18185152

+ZNF383chr19

37733371

+
intron-intronENST00000485631ENST00000352998BCL2L13chr22

18185152

+ZNF383chr19

37733371

+

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FusionProtFeatures for BCL2L13_ZNF383


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL2L13

Q9BXK5

ZNF383

Q8NA42

May promote the activation of caspase-3 and apoptosis. May function as a transcriptional repressor, suppressingtranscriptional activities mediated by MAPK signaling pathways.{ECO:0000269|PubMed:15964543}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BCL2L13_ZNF383


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BCL2L13_ZNF383


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BCL2L13GABARAPL2, APP, NINJ2, UPK1B, VAMP4, VAMP3, BET1, PLLP, TMUB2, TMEM128, TMEM86B, SOD1, SLC7A1, MTNR1BZNF383EWSR1, NXF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BCL2L13_ZNF383


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BCL2L13_ZNF383


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource