FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 40257

FusionGeneSummary for TYW1_DMTF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TYW1_DMTF1
Fusion gene ID: 40257
HgeneTgene
Gene symbol

TYW1

DMTF1

Gene ID

55253

9988

Gene nametRNA-yW synthesizing protein 1 homologcyclin D binding myb like transcription factor 1
SynonymsRSAFD1|TYW1A|YPL207WDMP1|DMTF|MRUL|hDMP1
Cytomap

7q11.21

7q21.12

Type of geneprotein-codingprotein-coding
DescriptionS-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthaseradical S-adenosyl methionine and flavodoxin domain-containing protein 1radical S-adenosyl methionine and flavodoxin domains 1tRNA wybutosine-synthesizing protein 1 homologtRNA-yW synthecyclin-D-binding Myb-like transcription factor 1cyclin D-binding Myb-like proteincyclin-D-interacting Myb-like protein 1hDMTF1
Modification date2018051920180523
UniProtAcc

Q9NV66

Q9Y222

Ensembl transtripts involved in fusion geneENST00000359626, ENST00000491969, 
ENST00000394702, ENST00000331242, 
ENST00000413276, ENST00000411766, 
ENST00000432937, ENST00000394703, 
ENST00000580710, ENST00000414194, 
Fusion gene scores* DoF score7 X 5 X 6=2104 X 4 X 3=48
# samples 74
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TYW1 [Title/Abstract] AND DMTF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-JY-A6FH-01ATYW1chr7

66582605

+DMTF1chr7

86795799

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000359626ENST00000394702TYW1chr7

66582605

+DMTF1chr7

86795799

+
Frame-shitENST00000359626ENST00000331242TYW1chr7

66582605

+DMTF1chr7

86795799

+
Frame-shitENST00000359626ENST00000413276TYW1chr7

66582605

+DMTF1chr7

86795799

+
5CDS-intronENST00000359626ENST00000411766TYW1chr7

66582605

+DMTF1chr7

86795799

+
5CDS-5UTRENST00000359626ENST00000432937TYW1chr7

66582605

+DMTF1chr7

86795799

+
5CDS-5UTRENST00000359626ENST00000394703TYW1chr7

66582605

+DMTF1chr7

86795799

+
5CDS-intronENST00000359626ENST00000580710TYW1chr7

66582605

+DMTF1chr7

86795799

+
5CDS-5UTRENST00000359626ENST00000414194TYW1chr7

66582605

+DMTF1chr7

86795799

+
intron-3CDSENST00000491969ENST00000394702TYW1chr7

66582605

+DMTF1chr7

86795799

+
intron-3CDSENST00000491969ENST00000331242TYW1chr7

66582605

+DMTF1chr7

86795799

+
intron-3CDSENST00000491969ENST00000413276TYW1chr7

66582605

+DMTF1chr7

86795799

+
intron-intronENST00000491969ENST00000411766TYW1chr7

66582605

+DMTF1chr7

86795799

+
intron-5UTRENST00000491969ENST00000432937TYW1chr7

66582605

+DMTF1chr7

86795799

+
intron-5UTRENST00000491969ENST00000394703TYW1chr7

66582605

+DMTF1chr7

86795799

+
intron-intronENST00000491969ENST00000580710TYW1chr7

66582605

+DMTF1chr7

86795799

+
intron-5UTRENST00000491969ENST00000414194TYW1chr7

66582605

+DMTF1chr7

86795799

+

Top

FusionProtFeatures for TYW1_DMTF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TYW1

Q9NV66

DMTF1

Q9Y222

Probable component of the wybutosine biosynthesispathway. Wybutosine is a hyper modified guanosine with a tricyclicbase found at the 3'-position adjacent to the anticodon ofeukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form thetricyclic 4-demethylwyosine, an intermediate in wybutosinebiosynthesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TYW1_DMTF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TYW1_DMTF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TYW1ELAVL1, MMS19, LYN, FAM96B, CIAO1, SPINT2, TMEM59, TSPAN17, BTN2A1, FAM189A2, EVA1C, LRRTM2, ZNRF4, GDPD5, LRRTM1, KLHL40, DLK2, RGS20, KCNS3, KCNC4, PCDHA3, NMUR2, PCDHGB4, IL17RC, RNF170, PDGFRB, IL17RB, GPR156, TMPRSS3, CHRND, ADAM33, PCDHGA5, PMEL, PCDHAC1, ATP6V0A2DMTF1TP53, SRA1, DNMT3L, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TYW1_DMTF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TYW1_DMTF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource