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Fusion gene ID: 40232 |
FusionGeneSummary for TXN_IL1B |
Fusion gene summary |
Fusion gene information | Fusion gene name: TXN_IL1B | Fusion gene ID: 40232 | Hgene | Tgene | Gene symbol | TXN | IL1B | Gene ID | 25828 | 3553 |
Gene name | thioredoxin 2 | interleukin 1 beta | |
Synonyms | COXPD29|MT-TRX|MTRX|TRX2|TXN | IL-1|IL1-BETA|IL1F2 | |
Cytomap | 22q12.3 | 2q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | thioredoxin, mitochondrialmitochondrial thioredoxin | interleukin-1 betaIL-1 betacatabolinpreinterleukin 1 betapro-interleukin-1-beta | |
Modification date | 20180527 | 20180527 | |
UniProtAcc | P10599 | P01584 | |
Ensembl transtripts involved in fusion gene | ENST00000374515, ENST00000374517, ENST00000487892, | ENST00000263341, ENST00000491056, | |
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 3 X 3 X 3=27 |
# samples | 3 | 3 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TXN [Title/Abstract] AND IL1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | IL1B | GO:0000187 | activation of MAPK activity | 10748004 |
Tgene | IL1B | GO:0001934 | positive regulation of protein phosphorylation | 10748004 |
Tgene | IL1B | GO:0006954 | inflammatory response | 10748004|21147091 |
Tgene | IL1B | GO:0008284 | positive regulation of cell proliferation | 25204733 |
Tgene | IL1B | GO:0008285 | negative regulation of cell proliferation | 3493774 |
Tgene | IL1B | GO:0010575 | positive regulation of vascular endothelial growth factor production | 12958148 |
Tgene | IL1B | GO:0010628 | positive regulation of gene expression | 21559518|23817958|26687115 |
Tgene | IL1B | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 25204733 |
Tgene | IL1B | GO:0019221 | cytokine-mediated signaling pathway | 10748004 |
Tgene | IL1B | GO:0030213 | hyaluronan biosynthetic process | 15100360 |
Tgene | IL1B | GO:0030335 | positive regulation of cell migration | 25204733 |
Tgene | IL1B | GO:0030730 | sequestering of triglyceride | 19032770 |
Tgene | IL1B | GO:0031663 | lipopolysaccharide-mediated signaling pathway | 21147091 |
Tgene | IL1B | GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production | 20027291 |
Tgene | IL1B | GO:0032729 | positive regulation of interferon-gamma production | 20027291 |
Tgene | IL1B | GO:0032757 | positive regulation of interleukin-8 production | 19524870 |
Tgene | IL1B | GO:0034116 | positive regulation of heterotypic cell-cell adhesion | 15100360 |
Tgene | IL1B | GO:0035505 | positive regulation of myosin light chain kinase activity | 18390750 |
Tgene | IL1B | GO:0035690 | cellular response to drug | 19158679 |
Tgene | IL1B | GO:0042102 | positive regulation of T cell proliferation | 1919436 |
Tgene | IL1B | GO:0043122 | regulation of I-kappaB kinase/NF-kappaB signaling | 10748004 |
Tgene | IL1B | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 8383325 |
Tgene | IL1B | GO:0045766 | positive regulation of angiogenesis | 25204733 |
Tgene | IL1B | GO:0045893 | positive regulation of transcription, DNA-templated | 15100360 |
Tgene | IL1B | GO:0050796 | regulation of insulin secretion | 8383325 |
Tgene | IL1B | GO:0050995 | negative regulation of lipid catabolic process | 19032770 |
Tgene | IL1B | GO:0050999 | regulation of nitric-oxide synthase activity | 15899045 |
Tgene | IL1B | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis | 18373975 |
Tgene | IL1B | GO:0051091 | positive regulation of DNA binding transcription factor activity | 10748004 |
Tgene | IL1B | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 10383454|12958148 |
Tgene | IL1B | GO:0060559 | positive regulation of calcidiol 1-monooxygenase activity | 16720713|17023519 |
Tgene | IL1B | GO:0070372 | regulation of ERK1 and ERK2 cascade | 25204733 |
Tgene | IL1B | GO:0070487 | monocyte aggregation | 15100360 |
Tgene | IL1B | GO:0071310 | cellular response to organic substance | 19158679 |
Tgene | IL1B | GO:0071407 | cellular response to organic cyclic compound | 21147091 |
Tgene | IL1B | GO:0071639 | positive regulation of monocyte chemotactic protein-1 production | 19524870 |
Tgene | IL1B | GO:1901224 | positive regulation of NIK/NF-kappaB signaling | 18390750 |
Tgene | IL1B | GO:1903140 | regulation of establishment of endothelial barrier | 25816133 |
Tgene | IL1B | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | 10748004 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA362147 | TXN | chr9 | 113007068 | - | IL1B | chr2 | 113587644 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000374515 | ENST00000263341 | TXN | chr9 | 113007068 | - | IL1B | chr2 | 113587644 | - |
intron-intron | ENST00000374515 | ENST00000491056 | TXN | chr9 | 113007068 | - | IL1B | chr2 | 113587644 | - |
intron-3UTR | ENST00000374517 | ENST00000263341 | TXN | chr9 | 113007068 | - | IL1B | chr2 | 113587644 | - |
intron-intron | ENST00000374517 | ENST00000491056 | TXN | chr9 | 113007068 | - | IL1B | chr2 | 113587644 | - |
intron-3UTR | ENST00000487892 | ENST00000263341 | TXN | chr9 | 113007068 | - | IL1B | chr2 | 113587644 | - |
intron-intron | ENST00000487892 | ENST00000491056 | TXN | chr9 | 113007068 | - | IL1B | chr2 | 113587644 | - |
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FusionProtFeatures for TXN_IL1B |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TXN | IL1B |
Participates in various redox reactions through thereversible oxidation of its active center dithiol to a disulfideand catalyzes dithiol-disulfide exchange reactions. Plays a rolein the reversible S-nitrosylation of cysteine residues in targetproteins, and thereby contributes to the response to intracellularnitric oxide. Nitrosylates the active site Cys of CASP3 inresponse to nitric oxide (NO), and thereby inhibits caspase-3activity. Induces the FOS/JUN AP-1 DNA-binding activity inionizing radiation (IR) cells through its oxidation/reductionstatus and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2receptor TAC (IL2R/P55). | Potent proinflammatory cytokine. Initially discovered asthe major endogenous pyrogen, induces prostaglandin synthesis,neutrophil influx and activation, T-cell activation and cytokineproduction, B-cell activation and antibody production, andfibroblast proliferation and collagen production. Promotes Th17differentiation of T-cells. Synergizes with IL12/interleukin-12 toinduce IFNG synthesis from T-helper 1 (Th1) cells(PubMed:10653850). {ECO:0000269|PubMed:10653850,ECO:0000269|PubMed:3920526}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TXN_IL1B |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TXN_IL1B |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TXN_IL1B |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | IL1B | P01584 | DB01017 | Minocycline | Interleukin-1 beta | small molecule | approved|investigational |
Tgene | IL1B | P01584 | DB06168 | Canakinumab | Interleukin-1 beta | biotech | approved|investigational |
Tgene | IL1B | P01584 | DB06372 | Rilonacept | Interleukin-1 beta | biotech | approved|investigational |
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RelatedDiseases for TXN_IL1B |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TXN | C0006287 | Bronchopulmonary Dysplasia | 1 | CTD_human |
Hgene | TXN | C0011616 | Contact Dermatitis | 1 | CTD_human |
Hgene | TXN | C0023895 | Liver diseases | 1 | CTD_human |
Hgene | TXN | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Hgene | TXN | C0242488 | Acute Lung Injury | 1 | CTD_human |
Hgene | TXN | C0345967 | Malignant mesothelioma | 1 | CTD_human |
Tgene | IL1B | C0021368 | Inflammation | 8 | CTD_human |
Tgene | IL1B | C0020429 | Hyperalgesia | 6 | CTD_human |
Tgene | IL1B | C0005586 | Bipolar Disorder | 5 | PSYGENET |
Tgene | IL1B | C0011570 | Mental Depression | 5 | PSYGENET |
Tgene | IL1B | C0011581 | Depressive disorder | 5 | PSYGENET |
Tgene | IL1B | C0015967 | Fever | 5 | CTD_human |
Tgene | IL1B | C0035126 | Reperfusion Injury | 5 | CTD_human |
Tgene | IL1B | C0041696 | Unipolar Depression | 5 | PSYGENET |
Tgene | IL1B | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Tgene | IL1B | C0001973 | Alcoholic Intoxication, Chronic | 4 | PSYGENET |
Tgene | IL1B | C0007786 | Brain Ischemia | 4 | CTD_human |
Tgene | IL1B | C0009324 | Ulcerative Colitis | 4 | CTD_human |
Tgene | IL1B | C0993582 | Arthritis, Experimental | 4 | CTD_human |
Tgene | IL1B | C0003873 | Rheumatoid Arthritis | 3 | CTD_human |
Tgene | IL1B | C0009375 | Colonic Neoplasms | 3 | CTD_human |
Tgene | IL1B | C0027051 | Myocardial Infarction | 3 | CTD_human |
Tgene | IL1B | C0027540 | Necrosis | 3 | CTD_human |
Tgene | IL1B | C0038356 | Stomach Neoplasms | 3 | CTD_human |
Tgene | IL1B | C0009319 | Colitis | 2 | CTD_human |
Tgene | IL1B | C0017658 | Glomerulonephritis | 2 | CTD_human |
Tgene | IL1B | C0020649 | Hypotension | 2 | CTD_human |
Tgene | IL1B | C0034069 | Pulmonary Fibrosis | 2 | CTD_human |
Tgene | IL1B | C0037274 | Dermatologic disorders | 2 | CTD_human |
Tgene | IL1B | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Tgene | IL1B | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | IL1B | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | IL1B | C0002395 | Alzheimer's Disease | 1 | CTD_human |
Tgene | IL1B | C0003123 | Anorexia | 1 | CTD_human |
Tgene | IL1B | C0003165 | Anthracosis | 1 | CTD_human |
Tgene | IL1B | C0004096 | Asthma | 1 | CTD_human |
Tgene | IL1B | C0006287 | Bronchopulmonary Dysplasia | 1 | CTD_human |
Tgene | IL1B | C0006663 | Calcinosis | 1 | CTD_human |
Tgene | IL1B | C0011615 | Dermatitis, Atopic | 1 | CTD_human |
Tgene | IL1B | C0011633 | Dermatomyositis | 1 | CTD_human |
Tgene | IL1B | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Tgene | IL1B | C0014324 | Entamoebiasis | 1 | CTD_human |
Tgene | IL1B | C0016059 | Fibrosis | 1 | CTD_human |
Tgene | IL1B | C0017154 | Gastritis, Atrophic | 1 | CTD_human |
Tgene | IL1B | C0017636 | Glioblastoma | 1 | CTD_human |
Tgene | IL1B | C0018099 | Gout | 1 | CTD_human |
Tgene | IL1B | C0018800 | Cardiomegaly | 1 | CTD_human |
Tgene | IL1B | C0018801 | Heart failure | 1 | CTD_human |
Tgene | IL1B | C0018824 | Heart valve disease | 1 | CTD_human |
Tgene | IL1B | C0018843 | Heat Stroke | 1 | CTD_human |
Tgene | IL1B | C0019061 | Hemolytic-Uremic Syndrome | 1 | CTD_human |
Tgene | IL1B | C0020452 | Hyperemia | 1 | CTD_human |
Tgene | IL1B | C0020517 | Hypersensitivity | 1 | CTD_human |
Tgene | IL1B | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | IL1B | C0020615 | Hypoglycemia | 1 | CTD_human |
Tgene | IL1B | C0022541 | Kearns-Sayre syndrome | 1 | CTD_human |
Tgene | IL1B | C0023186 | Learning Disorders | 1 | CTD_human |
Tgene | IL1B | C0023283 | Leishmaniasis, Cutaneous | 1 | CTD_human |
Tgene | IL1B | C0023290 | Leishmaniasis, Visceral | 1 | CTD_human |
Tgene | IL1B | C0023380 | Lethargy | 1 | CTD_human |
Tgene | IL1B | C0023518 | Leukocytosis | 1 | CTD_human |
Tgene | IL1B | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | IL1B | C0024121 | Lung Neoplasms | 1 | CTD_human |
Tgene | IL1B | C0024312 | Lymphopenia | 1 | CTD_human |
Tgene | IL1B | C0024809 | Marijuana Abuse | 1 | PSYGENET |
Tgene | IL1B | C0025261 | Memory Disorders | 1 | CTD_human |
Tgene | IL1B | C0026769 | Multiple Sclerosis | 1 | CTD_human |
Tgene | IL1B | C0026848 | Myopathy | 1 | CTD_human |
Tgene | IL1B | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | IL1B | C0027947 | Neutropenia | 1 | CTD_human |
Tgene | IL1B | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | IL1B | C0029458 | Osteoporosis, Postmenopausal | 1 | CTD_human |
Tgene | IL1B | C0030920 | Peptic Ulcer | 1 | CTD_human |
Tgene | IL1B | C0032231 | Pleurisy | 1 | CTD_human |
Tgene | IL1B | C0032285 | Pneumonia | 1 | CTD_human |
Tgene | IL1B | C0033860 | Psoriasis | 1 | CTD_human |
Tgene | IL1B | C0036341 | Schizophrenia | 1 | CTD_human |
Tgene | IL1B | C0036572 | Seizures | 1 | CTD_human |
Tgene | IL1B | C0037116 | Silicosis | 1 | CTD_human |
Tgene | IL1B | C0038358 | Gastric ulcer | 1 | CTD_human |
Tgene | IL1B | C0038454 | Cerebrovascular accident | 1 | CTD_human |
Tgene | IL1B | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
Tgene | IL1B | C0040997 | Trigeminal Neuralgia | 1 | CTD_human |
Tgene | IL1B | C0042109 | Urticaria | 1 | CTD_human |
Tgene | IL1B | C0085655 | Polymyositis | 1 | CTD_human |
Tgene | IL1B | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | IL1B | C0162670 | Mitochondrial Myopathies | 1 | CTD_human |
Tgene | IL1B | C0162671 | MELAS Syndrome | 1 | CTD_human |
Tgene | IL1B | C0162672 | MERRF Syndrome | 1 | CTD_human |
Tgene | IL1B | C0162674 | Chronic progressive external ophthalmoplegia | 1 | CTD_human |
Tgene | IL1B | C0311375 | Arsenic Poisoning | 1 | CTD_human |
Tgene | IL1B | C0333355 | Inflammatory disease of mucous membrane | 1 | CTD_human |
Tgene | IL1B | C0343755 | HIV Wasting Syndrome | 1 | CTD_human |
Tgene | IL1B | C0677050 | Manganese Poisoning | 1 | CTD_human |
Tgene | IL1B | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
Tgene | IL1B | C0878544 | Cardiomyopathies | 1 | CTD_human |
Tgene | IL1B | C0917796 | Optic Atrophy, Hereditary, Leber | 1 | CTD_human |
Tgene | IL1B | C4042891 | Sleep Wake Disorders | 1 | CTD_human |
Tgene | IL1B | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |