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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40232

FusionGeneSummary for TXN_IL1B

check button Fusion gene summary
Fusion gene informationFusion gene name: TXN_IL1B
Fusion gene ID: 40232
HgeneTgene
Gene symbol

TXN

IL1B

Gene ID

25828

3553

Gene namethioredoxin 2interleukin 1 beta
SynonymsCOXPD29|MT-TRX|MTRX|TRX2|TXNIL-1|IL1-BETA|IL1F2
Cytomap

22q12.3

2q14.1

Type of geneprotein-codingprotein-coding
Descriptionthioredoxin, mitochondrialmitochondrial thioredoxininterleukin-1 betaIL-1 betacatabolinpreinterleukin 1 betapro-interleukin-1-beta
Modification date2018052720180527
UniProtAcc

P10599

P01584

Ensembl transtripts involved in fusion geneENST00000374515, ENST00000374517, 
ENST00000487892, 
ENST00000263341, 
ENST00000491056, 
Fusion gene scores* DoF score3 X 3 X 3=273 X 3 X 3=27
# samples 33
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TXN [Title/Abstract] AND IL1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIL1B

GO:0000187

activation of MAPK activity

10748004

TgeneIL1B

GO:0001934

positive regulation of protein phosphorylation

10748004

TgeneIL1B

GO:0006954

inflammatory response

10748004|21147091

TgeneIL1B

GO:0008284

positive regulation of cell proliferation

25204733

TgeneIL1B

GO:0008285

negative regulation of cell proliferation

3493774

TgeneIL1B

GO:0010575

positive regulation of vascular endothelial growth factor production

12958148

TgeneIL1B

GO:0010628

positive regulation of gene expression

21559518|23817958|26687115

TgeneIL1B

GO:0010718

positive regulation of epithelial to mesenchymal transition

25204733

TgeneIL1B

GO:0019221

cytokine-mediated signaling pathway

10748004

TgeneIL1B

GO:0030213

hyaluronan biosynthetic process

15100360

TgeneIL1B

GO:0030335

positive regulation of cell migration

25204733

TgeneIL1B

GO:0030730

sequestering of triglyceride

19032770

TgeneIL1B

GO:0031663

lipopolysaccharide-mediated signaling pathway

21147091

TgeneIL1B

GO:0032725

positive regulation of granulocyte macrophage colony-stimulating factor production

20027291

TgeneIL1B

GO:0032729

positive regulation of interferon-gamma production

20027291

TgeneIL1B

GO:0032757

positive regulation of interleukin-8 production

19524870

TgeneIL1B

GO:0034116

positive regulation of heterotypic cell-cell adhesion

15100360

TgeneIL1B

GO:0035505

positive regulation of myosin light chain kinase activity

18390750

TgeneIL1B

GO:0035690

cellular response to drug

19158679

TgeneIL1B

GO:0042102

positive regulation of T cell proliferation

1919436

TgeneIL1B

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

10748004

TgeneIL1B

GO:0045429

positive regulation of nitric oxide biosynthetic process

8383325

TgeneIL1B

GO:0045766

positive regulation of angiogenesis

25204733

TgeneIL1B

GO:0045893

positive regulation of transcription, DNA-templated

15100360

TgeneIL1B

GO:0050796

regulation of insulin secretion

8383325

TgeneIL1B

GO:0050995

negative regulation of lipid catabolic process

19032770

TgeneIL1B

GO:0050999

regulation of nitric-oxide synthase activity

15899045

TgeneIL1B

GO:0051044

positive regulation of membrane protein ectodomain proteolysis

18373975

TgeneIL1B

GO:0051091

positive regulation of DNA binding transcription factor activity

10748004

TgeneIL1B

GO:0051092

positive regulation of NF-kappaB transcription factor activity

10383454|12958148

TgeneIL1B

GO:0060559

positive regulation of calcidiol 1-monooxygenase activity

16720713|17023519

TgeneIL1B

GO:0070372

regulation of ERK1 and ERK2 cascade

25204733

TgeneIL1B

GO:0070487

monocyte aggregation

15100360

TgeneIL1B

GO:0071310

cellular response to organic substance

19158679

TgeneIL1B

GO:0071407

cellular response to organic cyclic compound

21147091

TgeneIL1B

GO:0071639

positive regulation of monocyte chemotactic protein-1 production

19524870

TgeneIL1B

GO:1901224

positive regulation of NIK/NF-kappaB signaling

18390750

TgeneIL1B

GO:1903140

regulation of establishment of endothelial barrier

25816133

TgeneIL1B

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

10748004


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA362147TXNchr9

113007068

-IL1Bchr2

113587644

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000374515ENST00000263341TXNchr9

113007068

-IL1Bchr2

113587644

-
intron-intronENST00000374515ENST00000491056TXNchr9

113007068

-IL1Bchr2

113587644

-
intron-3UTRENST00000374517ENST00000263341TXNchr9

113007068

-IL1Bchr2

113587644

-
intron-intronENST00000374517ENST00000491056TXNchr9

113007068

-IL1Bchr2

113587644

-
intron-3UTRENST00000487892ENST00000263341TXNchr9

113007068

-IL1Bchr2

113587644

-
intron-intronENST00000487892ENST00000491056TXNchr9

113007068

-IL1Bchr2

113587644

-

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FusionProtFeatures for TXN_IL1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TXN

P10599

IL1B

P01584

Participates in various redox reactions through thereversible oxidation of its active center dithiol to a disulfideand catalyzes dithiol-disulfide exchange reactions. Plays a rolein the reversible S-nitrosylation of cysteine residues in targetproteins, and thereby contributes to the response to intracellularnitric oxide. Nitrosylates the active site Cys of CASP3 inresponse to nitric oxide (NO), and thereby inhibits caspase-3activity. Induces the FOS/JUN AP-1 DNA-binding activity inionizing radiation (IR) cells through its oxidation/reductionstatus and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2receptor TAC (IL2R/P55). Potent proinflammatory cytokine. Initially discovered asthe major endogenous pyrogen, induces prostaglandin synthesis,neutrophil influx and activation, T-cell activation and cytokineproduction, B-cell activation and antibody production, andfibroblast proliferation and collagen production. Promotes Th17differentiation of T-cells. Synergizes with IL12/interleukin-12 toinduce IFNG synthesis from T-helper 1 (Th1) cells(PubMed:10653850). {ECO:0000269|PubMed:10653850,ECO:0000269|PubMed:3920526}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TXN_IL1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TXN_IL1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TXN_IL1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneIL1BP01584DB01017MinocyclineInterleukin-1 betasmall moleculeapproved|investigational
TgeneIL1BP01584DB06168CanakinumabInterleukin-1 betabiotechapproved|investigational
TgeneIL1BP01584DB06372RilonaceptInterleukin-1 betabiotechapproved|investigational

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RelatedDiseases for TXN_IL1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTXNC0006287Bronchopulmonary Dysplasia1CTD_human
HgeneTXNC0011616Contact Dermatitis1CTD_human
HgeneTXNC0023895Liver diseases1CTD_human
HgeneTXNC0027626Neoplasm Invasiveness1CTD_human
HgeneTXNC0242488Acute Lung Injury1CTD_human
HgeneTXNC0345967Malignant mesothelioma1CTD_human
TgeneIL1BC0021368Inflammation8CTD_human
TgeneIL1BC0020429Hyperalgesia6CTD_human
TgeneIL1BC0005586Bipolar Disorder5PSYGENET
TgeneIL1BC0011570Mental Depression5PSYGENET
TgeneIL1BC0011581Depressive disorder5PSYGENET
TgeneIL1BC0015967Fever5CTD_human
TgeneIL1BC0035126Reperfusion Injury5CTD_human
TgeneIL1BC0041696Unipolar Depression5PSYGENET
TgeneIL1BC1269683Major Depressive Disorder5PSYGENET
TgeneIL1BC0001973Alcoholic Intoxication, Chronic4PSYGENET
TgeneIL1BC0007786Brain Ischemia4CTD_human
TgeneIL1BC0009324Ulcerative Colitis4CTD_human
TgeneIL1BC0993582Arthritis, Experimental4CTD_human
TgeneIL1BC0003873Rheumatoid Arthritis3CTD_human
TgeneIL1BC0009375Colonic Neoplasms3CTD_human
TgeneIL1BC0027051Myocardial Infarction3CTD_human
TgeneIL1BC0027540Necrosis3CTD_human
TgeneIL1BC0038356Stomach Neoplasms3CTD_human
TgeneIL1BC0009319Colitis2CTD_human
TgeneIL1BC0017658Glomerulonephritis2CTD_human
TgeneIL1BC0020649Hypotension2CTD_human
TgeneIL1BC0034069Pulmonary Fibrosis2CTD_human
TgeneIL1BC0037274Dermatologic disorders2CTD_human
TgeneIL1BC1458155Mammary Neoplasms2CTD_human
TgeneIL1BC0000786Spontaneous abortion1CTD_human
TgeneIL1BC0001418Adenocarcinoma1CTD_human
TgeneIL1BC0002395Alzheimer's Disease1CTD_human
TgeneIL1BC0003123Anorexia1CTD_human
TgeneIL1BC0003165Anthracosis1CTD_human
TgeneIL1BC0004096Asthma1CTD_human
TgeneIL1BC0006287Bronchopulmonary Dysplasia1CTD_human
TgeneIL1BC0006663Calcinosis1CTD_human
TgeneIL1BC0011615Dermatitis, Atopic1CTD_human
TgeneIL1BC0011633Dermatomyositis1CTD_human
TgeneIL1BC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneIL1BC0014324Entamoebiasis1CTD_human
TgeneIL1BC0016059Fibrosis1CTD_human
TgeneIL1BC0017154Gastritis, Atrophic1CTD_human
TgeneIL1BC0017636Glioblastoma1CTD_human
TgeneIL1BC0018099Gout1CTD_human
TgeneIL1BC0018800Cardiomegaly1CTD_human
TgeneIL1BC0018801Heart failure1CTD_human
TgeneIL1BC0018824Heart valve disease1CTD_human
TgeneIL1BC0018843Heat Stroke1CTD_human
TgeneIL1BC0019061Hemolytic-Uremic Syndrome1CTD_human
TgeneIL1BC0020452Hyperemia1CTD_human
TgeneIL1BC0020517Hypersensitivity1CTD_human
TgeneIL1BC0020538Hypertensive disease1CTD_human
TgeneIL1BC0020615Hypoglycemia1CTD_human
TgeneIL1BC0022541Kearns-Sayre syndrome1CTD_human
TgeneIL1BC0023186Learning Disorders1CTD_human
TgeneIL1BC0023283Leishmaniasis, Cutaneous1CTD_human
TgeneIL1BC0023290Leishmaniasis, Visceral1CTD_human
TgeneIL1BC0023380Lethargy1CTD_human
TgeneIL1BC0023518Leukocytosis1CTD_human
TgeneIL1BC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneIL1BC0024121Lung Neoplasms1CTD_human
TgeneIL1BC0024312Lymphopenia1CTD_human
TgeneIL1BC0024809Marijuana Abuse1PSYGENET
TgeneIL1BC0025261Memory Disorders1CTD_human
TgeneIL1BC0026769Multiple Sclerosis1CTD_human
TgeneIL1BC0026848Myopathy1CTD_human
TgeneIL1BC0027626Neoplasm Invasiveness1CTD_human
TgeneIL1BC0027947Neutropenia1CTD_human
TgeneIL1BC0029408Degenerative polyarthritis1CTD_human
TgeneIL1BC0029458Osteoporosis, Postmenopausal1CTD_human
TgeneIL1BC0030920Peptic Ulcer1CTD_human
TgeneIL1BC0032231Pleurisy1CTD_human
TgeneIL1BC0032285Pneumonia1CTD_human
TgeneIL1BC0033860Psoriasis1CTD_human
TgeneIL1BC0036341Schizophrenia1CTD_human
TgeneIL1BC0036572Seizures1CTD_human
TgeneIL1BC0037116Silicosis1CTD_human
TgeneIL1BC0038358Gastric ulcer1CTD_human
TgeneIL1BC0038454Cerebrovascular accident1CTD_human
TgeneIL1BC0040136Thyroid Neoplasm1CTD_human
TgeneIL1BC0040997Trigeminal Neuralgia1CTD_human
TgeneIL1BC0042109Urticaria1CTD_human
TgeneIL1BC0085655Polymyositis1CTD_human
TgeneIL1BC0151744Myocardial Ischemia1CTD_human
TgeneIL1BC0162670Mitochondrial Myopathies1CTD_human
TgeneIL1BC0162671MELAS Syndrome1CTD_human
TgeneIL1BC0162672MERRF Syndrome1CTD_human
TgeneIL1BC0162674Chronic progressive external ophthalmoplegia1CTD_human
TgeneIL1BC0311375Arsenic Poisoning1CTD_human
TgeneIL1BC0333355Inflammatory disease of mucous membrane1CTD_human
TgeneIL1BC0343755HIV Wasting Syndrome1CTD_human
TgeneIL1BC0677050Manganese Poisoning1CTD_human
TgeneIL1BC0740392Infarction, Middle Cerebral Artery1CTD_human
TgeneIL1BC0878544Cardiomyopathies1CTD_human
TgeneIL1BC0917796Optic Atrophy, Hereditary, Leber1CTD_human
TgeneIL1BC4042891Sleep Wake Disorders1CTD_human
TgeneIL1BC4277682Chemical and Drug Induced Liver Injury1CTD_human