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Fusion gene ID: 40231 |
FusionGeneSummary for TXN_GNB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TXN_GNB1 | Fusion gene ID: 40231 | Hgene | Tgene | Gene symbol | TXN | GNB1 | Gene ID | 25828 | 2782 |
| Gene name | thioredoxin 2 | G protein subunit beta 1 | |
| Synonyms | COXPD29|MT-TRX|MTRX|TRX2|TXN | MRD42 | |
| Cytomap | 22q12.3 | 1p36.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thioredoxin, mitochondrialmitochondrial thioredoxin | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1beta subunit, signal-transducing proteins GS/GIguanine nucleotide binding protein (G protein), beta polypeptide 1testicular tissue protein Li 72transducin beta chain 1 | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | P10599 | P62873 | |
| Ensembl transtripts involved in fusion gene | ENST00000374515, ENST00000374517, ENST00000487892, | ENST00000378609, ENST00000472614, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 17 X 20 X 9=3060 |
| # samples | 3 | 26 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(26/3060*10)=-3.55694812455156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TXN [Title/Abstract] AND GNB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-LN-A9FR-01A | TXN | chr9 | 113007058 | - | GNB1 | chr1 | 1720708 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000374515 | ENST00000378609 | TXN | chr9 | 113007058 | - | GNB1 | chr1 | 1720708 | - |
| 5CDS-intron | ENST00000374515 | ENST00000472614 | TXN | chr9 | 113007058 | - | GNB1 | chr1 | 1720708 | - |
| In-frame | ENST00000374517 | ENST00000378609 | TXN | chr9 | 113007058 | - | GNB1 | chr1 | 1720708 | - |
| 5CDS-intron | ENST00000374517 | ENST00000472614 | TXN | chr9 | 113007058 | - | GNB1 | chr1 | 1720708 | - |
| 5UTR-3CDS | ENST00000487892 | ENST00000378609 | TXN | chr9 | 113007058 | - | GNB1 | chr1 | 1720708 | - |
| 5UTR-intron | ENST00000487892 | ENST00000472614 | TXN | chr9 | 113007058 | - | GNB1 | chr1 | 1720708 | - |
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FusionProtFeatures for TXN_GNB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TXN | GNB1 |
| Participates in various redox reactions through thereversible oxidation of its active center dithiol to a disulfideand catalyzes dithiol-disulfide exchange reactions. Plays a rolein the reversible S-nitrosylation of cysteine residues in targetproteins, and thereby contributes to the response to intracellularnitric oxide. Nitrosylates the active site Cys of CASP3 inresponse to nitric oxide (NO), and thereby inhibits caspase-3activity. Induces the FOS/JUN AP-1 DNA-binding activity inionizing radiation (IR) cells through its oxidation/reductionstatus and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2receptor TAC (IL2R/P55). | Guanine nucleotide-binding proteins (G proteins) areinvolved as a modulator or transducer in various transmembranesignaling systems. The beta and gamma chains are required for theGTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >GNB1 | chr9:113007058 | chr1:1720708 | ENST00000378609 | - | 8 | 12 | 268_298 | 233 | 872 | Repeat | Note=WD 6 |
| Tgene | >GNB1 | chr9:113007058 | chr1:1720708 | ENST00000378609 | - | 8 | 12 | 310_340 | 233 | 872 | Repeat | Note=WD 7 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TXN | chr9:113007058 | chr1:1720708 | ENST00000374515 | - | 3 | 4 | 2_105 | 65 | 86 | Domain | Thioredoxin |
| Hgene | >TXN | chr9:113007058 | chr1:1720708 | ENST00000374517 | - | 4 | 5 | 2_105 | 85 | 106 | Domain | Thioredoxin |
| Tgene | GNB1 | chr9:113007058 | chr1:1720708 | ENST00000378609 | - | 8 | 12 | 141_170 | 233 | 872 | Repeat | Note=WD 3 |
| Tgene | GNB1 | chr9:113007058 | chr1:1720708 | ENST00000378609 | - | 8 | 12 | 182_212 | 233 | 872 | Repeat | Note=WD 4 |
| Tgene | GNB1 | chr9:113007058 | chr1:1720708 | ENST00000378609 | - | 8 | 12 | 224_254 | 233 | 872 | Repeat | Note=WD 5 |
| Tgene | GNB1 | chr9:113007058 | chr1:1720708 | ENST00000378609 | - | 8 | 12 | 53_83 | 233 | 872 | Repeat | Note=WD 1 |
| Tgene | GNB1 | chr9:113007058 | chr1:1720708 | ENST00000378609 | - | 8 | 12 | 95_125 | 233 | 872 | Repeat | Note=WD 2 |
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FusionGeneSequence for TXN_GNB1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TXN_ENST00000374515_chr9_113007058_-_GNB1_ENST00000378609_chr1_1720708_-_173aa MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHDVASECEVKCMPTFQFFKKGQKFFPNGNAFATGSDDATCRLFDLRAD >In-frame_TXN_ENST00000374517_chr9_113007058_-_GNB1_ENST00000378609_chr1_1720708_-_193aa MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKFFPNG NAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TXN_ENST00000374515_chr9_113007058_-_GNB1_ENST00000378609_chr1_1720708_-_519nt ATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACG TGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTT AAGAAGGGACAAAAGTTCTTTCCAAATGGCAATGCATTTGCCACTGGCTCAGACGACGCCACCTGCAGGCTGTTTGACCTTCGTGCTGAC CAGGAGCTCATGACTTACTCCCATGACAACATCATCTGCGGGATCACCTCTGTCTCCTTCTCCAAGAGCGGGCGCCTCCTCCTTGCTGGG TACGACGACTTCAACTGCAACGTCTGGGATGCACTCAAAGCCGACCGGGCAGGTGTCTTGGCTGGGCATGACAACCGCGTCAGCTGCCTG >In-frame_TXN_ENST00000374517_chr9_113007058_-_GNB1_ENST00000378609_chr1_1720708_-_579nt ATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACTTGTAGTAGTTGACTTCTCAGCCACG TGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGTGATATTCCTTGAAGTAGATGTGGAT GACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGTTCTTTCCAAATGGC AATGCATTTGCCACTGGCTCAGACGACGCCACCTGCAGGCTGTTTGACCTTCGTGCTGACCAGGAGCTCATGACTTACTCCCATGACAAC ATCATCTGCGGGATCACCTCTGTCTCCTTCTCCAAGAGCGGGCGCCTCCTCCTTGCTGGGTACGACGACTTCAACTGCAACGTCTGGGAT GCACTCAAAGCCGACCGGGCAGGTGTCTTGGCTGGGCATGACAACCGCGTCAGCTGCCTGGGCGTGACTGACGATGGCATGGCTGTGGCG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TXN_ENST00000374515_chr9_113007058_-_GNB1_ENST00000378609_chr1_1720708_-_2323nt TACAGCCGCTCGTCAGACTCCAGCAGCCAAGATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGA TAAACTTGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATGATGTTGCTTCAGAGTGTGA AGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAAGGGACAAAAGTTCTTTCCAAATGGCAATGCATTTGCCACTGGCTCAGACGACGC CACCTGCAGGCTGTTTGACCTTCGTGCTGACCAGGAGCTCATGACTTACTCCCATGACAACATCATCTGCGGGATCACCTCTGTCTCCTT CTCCAAGAGCGGGCGCCTCCTCCTTGCTGGGTACGACGACTTCAACTGCAACGTCTGGGATGCACTCAAAGCCGACCGGGCAGGTGTCTT GGCTGGGCATGACAACCGCGTCAGCTGCCTGGGCGTGACTGACGATGGCATGGCTGTGGCGACAGGGTCCTGGGATAGCTTCCTCAAGAT CTGGAACTAACGCCAGTAGCATGTGGATGCCATGGAGACTGGAAGACCATTCCAACTTGGACGCGTTACCATGAGAGCATATCCTATCCA ACCGTACTAACGTGGACACCCTACACCTCCCCTCAGAACTTCAAAAGGGCAAGATCTTTTTTCCTTCACTTATTGCTGAAACCAAGAGCA CAATTCCCATTGAGAGAAAGATCTCTGTGCTGTAAACTAAAACAAATTGTGCATTCCTTCCGGGGCCATCGTCTTTGTTTTCTTTTTTGT CTTGAATGAATTTTAAAAGGAAATATATAATAAAAATGTTAACCAGAAGGTAAACTTGAGTGTAATTGTCAGACAGACACACTTTTCCAC CAGTGTATTTGAATTTTAGACCAGTGACCCTGTTTTGTGGCATTCATGCAAAACATGCTGAGGGCTTTGTTCATCTGGTCATCGTGTCCA AATTTCAGTCATGTTTGTAGCAAGATTTTGGAAGCATTCATATTTCCTTTTTAAAATGTATTCCTTTGTGTTCAACAGTTAATCAAAACC AGAGAGTCTAGGGCAGCCTCTCTGATGTTGTCAATGATGTAAATTCAGTCCCTGGTTTTTAATTTTCTGTCTGATGTCACAGATCATTGT TGCACACAAACGTGGCATAGAAAAGAACATGTTCAGAAGCCATGGGGCCAAGCACATGCGGGGACGGTCTCAAATGCGTGATCAGAGAAT CCTTCACCTTTGCTGAAAAGTGAGCTCAGATCCAGCACCATGTTCCTCCTGACCCATCCTGTCTATCTTCTCAGTTGAGTTTTTAATCTC ACTTTGGGTTTCCTTGTGAAGTTGGAGGGAAGTTTATAATAGCCTAACACTACCCCACCCCCAACTAGGAGGAACCTCTGTTTTCAAGAG AGATGCCTGTCCTGTGCTTGGATAGTCAGTCAATTATTTGTGTATGAAACAATGTACAAATCAATGTTTTGAAAATAATGATCTCAGACT TTCTAAGTTAAATTTTAAAAATTTTGATTGTTTGCCATATTGGGTGGGTTTACTCTTAGAATCGCATGCTGTAGAAATGCTCAAAAGTGC ATATGGGACTCAGTCCTTAGGTGTTCTTTTTCTTTTAAGAAATAACCTCTTACAGTTGTAACCATTGCGGCTCTGTCCACTTCTCGTTGC TGCTCTGTGGCACATATCGGAAGCAGTACAGCGCGCGGCTCTACACGCTTGGGTAGCGGGATAAGTCACTGTTTTCTTTATTTCTTTAAA AAAAAAAAAGTTCTGTTGCAAACGACTGCTGTTGGATTCTGAGGGTGGGGAGGGAGAGAGAGGGAGGGAGAGGGAGTGAAGAGCCTGCCC TCCTATATGGATTCTTCAGGGCCCTCCACATCTGAGGTGGCTCATTCCCATCACACACAGATTGTCCTGGTGTTCATTTCAAGGCCAGTG TTCAGCAGCAGCGTTTGGAAAGCAGGTTCTGTGGGACCCCCCGCCCCGCCCCCCGCACTCCTTCATAGCAGCAGTAGTGGCTTCTCCATC CTGTTTTCTGCAACATTCTATACAAAACTGTGCTGTGACCTTGCGGTAGGCCTGGATCTGGCAAAGAGAATACAAATGAAACCCCTTCTT TCTCTTTCCGTCCAACAACTCTGTAGAGCTCTCTGCACCCTTACCCCTTTCCACCTTTTGTATTTAATTTTAAAGTCAGTGTACTGCAAG >In-frame_TXN_ENST00000374517_chr9_113007058_-_GNB1_ENST00000378609_chr1_1720708_-_2557nt CTCGCAGGCTCCAGGGGCGGGGCGTGGCCGGGGCGCAGCGACGGGCGCGGAGGTCCGGCCGGGCGCGCGCGCCCCCGCCACACGCACGCC GGGCGTGCCAGTTTATAAAGGGAGAGAGCAAGCAGCGAGTCTTGAAGCTCTGTTTGGTGCTTTGGATCCATTTCCATCGGTCCTTACAGC CGCTCGTCAGACTCCAGCAGCCAAGATGGTGAAGCAGATCGAGAGCAAGACTGCTTTTCAGGAAGCCTTGGACGCTGCAGGTGATAAACT TGTAGTAGTTGACTTCTCAGCCACGTGGTGTGGGCCTTGCAAAATGATCAAGCCTTTCTTTCATTCCCTCTCTGAAAAGTATTCCAACGT GATATTCCTTGAAGTAGATGTGGATGACTGTCAGGATGTTGCTTCAGAGTGTGAAGTCAAATGCATGCCAACATTCCAGTTTTTTAAGAA GGGACAAAAGTTCTTTCCAAATGGCAATGCATTTGCCACTGGCTCAGACGACGCCACCTGCAGGCTGTTTGACCTTCGTGCTGACCAGGA GCTCATGACTTACTCCCATGACAACATCATCTGCGGGATCACCTCTGTCTCCTTCTCCAAGAGCGGGCGCCTCCTCCTTGCTGGGTACGA CGACTTCAACTGCAACGTCTGGGATGCACTCAAAGCCGACCGGGCAGGTGTCTTGGCTGGGCATGACAACCGCGTCAGCTGCCTGGGCGT GACTGACGATGGCATGGCTGTGGCGACAGGGTCCTGGGATAGCTTCCTCAAGATCTGGAACTAACGCCAGTAGCATGTGGATGCCATGGA GACTGGAAGACCATTCCAACTTGGACGCGTTACCATGAGAGCATATCCTATCCAACCGTACTAACGTGGACACCCTACACCTCCCCTCAG AACTTCAAAAGGGCAAGATCTTTTTTCCTTCACTTATTGCTGAAACCAAGAGCACAATTCCCATTGAGAGAAAGATCTCTGTGCTGTAAA CTAAAACAAATTGTGCATTCCTTCCGGGGCCATCGTCTTTGTTTTCTTTTTTGTCTTGAATGAATTTTAAAAGGAAATATATAATAAAAA TGTTAACCAGAAGGTAAACTTGAGTGTAATTGTCAGACAGACACACTTTTCCACCAGTGTATTTGAATTTTAGACCAGTGACCCTGTTTT GTGGCATTCATGCAAAACATGCTGAGGGCTTTGTTCATCTGGTCATCGTGTCCAAATTTCAGTCATGTTTGTAGCAAGATTTTGGAAGCA TTCATATTTCCTTTTTAAAATGTATTCCTTTGTGTTCAACAGTTAATCAAAACCAGAGAGTCTAGGGCAGCCTCTCTGATGTTGTCAATG ATGTAAATTCAGTCCCTGGTTTTTAATTTTCTGTCTGATGTCACAGATCATTGTTGCACACAAACGTGGCATAGAAAAGAACATGTTCAG AAGCCATGGGGCCAAGCACATGCGGGGACGGTCTCAAATGCGTGATCAGAGAATCCTTCACCTTTGCTGAAAAGTGAGCTCAGATCCAGC ACCATGTTCCTCCTGACCCATCCTGTCTATCTTCTCAGTTGAGTTTTTAATCTCACTTTGGGTTTCCTTGTGAAGTTGGAGGGAAGTTTA TAATAGCCTAACACTACCCCACCCCCAACTAGGAGGAACCTCTGTTTTCAAGAGAGATGCCTGTCCTGTGCTTGGATAGTCAGTCAATTA TTTGTGTATGAAACAATGTACAAATCAATGTTTTGAAAATAATGATCTCAGACTTTCTAAGTTAAATTTTAAAAATTTTGATTGTTTGCC ATATTGGGTGGGTTTACTCTTAGAATCGCATGCTGTAGAAATGCTCAAAAGTGCATATGGGACTCAGTCCTTAGGTGTTCTTTTTCTTTT AAGAAATAACCTCTTACAGTTGTAACCATTGCGGCTCTGTCCACTTCTCGTTGCTGCTCTGTGGCACATATCGGAAGCAGTACAGCGCGC GGCTCTACACGCTTGGGTAGCGGGATAAGTCACTGTTTTCTTTATTTCTTTAAAAAAAAAAAAGTTCTGTTGCAAACGACTGCTGTTGGA TTCTGAGGGTGGGGAGGGAGAGAGAGGGAGGGAGAGGGAGTGAAGAGCCTGCCCTCCTATATGGATTCTTCAGGGCCCTCCACATCTGAG GTGGCTCATTCCCATCACACACAGATTGTCCTGGTGTTCATTTCAAGGCCAGTGTTCAGCAGCAGCGTTTGGAAAGCAGGTTCTGTGGGA CCCCCCGCCCCGCCCCCCGCACTCCTTCATAGCAGCAGTAGTGGCTTCTCCATCCTGTTTTCTGCAACATTCTATACAAAACTGTGCTGT GACCTTGCGGTAGGCCTGGATCTGGCAAAGAGAATACAAATGAAACCCCTTCTTTCTCTTTCCGTCCAACAACTCTGTAGAGCTCTCTGC ACCCTTACCCCTTTCCACCTTTTGTATTTAATTTTAAAGTCAGTGTACTGCAAGGAAGCTGGATGCAAGATAGATACTATATTAAACTGT |
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FusionGenePPI for TXN_GNB1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TXN | COL1A1, NCF4, PINX1, VHL, CD40, GAPDH, NR3C1, FST, VIM, TXNIP, MAP3K5, NFKB1, TP53, UCHL5, CUL4B, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, PTPN6, WDR1, UBQLN4, AHCYL1, UBE2V1, SSSCA1, ATP6V1F, SFPQ, SFXN1, UBL5, UBE2D2, SYNCRIP, ATIC, UBE2K, TAX1BP3, PRDX1, MYC, IFIT3, UBL4A, PAN2, NPM1, MYD88, GPRASP2, DYNLT1, CDKN1A, MLH1, NFE2, SIAH1, ACTN4, PARK2, APEX1, SRP9, GPX1, UNK, NTRK1, AKR7A2, ARHGDIA, CCS, EEF2, EIF4EBP2, GLOD4, GSTO1, HINT1, HSPE1, IMPA2, PDCD6, PRDX2, RAB1A, SOD1, STIP1, TAGLN2, TAGLN3, ASS1, C4orf27, ENO1, ENO2, ENO3, FKBP1A, FKBP2, GLRX5, GSTO2, HSPA5, IMPA1, LGALS3, MAP2K2, PGAM1, PGAM2, PSMD14, RAE1, TMX1, TXN2, TYMS, REV3L, PTEN, EWSR1, SRPK2, GEMIN5, TOR1AIP1, EGFR, CRY1, MCM2, OTUB1, PCGF1, DPPA4, NANOG, POU5F1, CRBN, DUSP13, CDK1, COQ2, COX15, DLD, DNM1L, PARK7, SOAT1, VDAC1, G3BP1 | GNB1 | ARHGEF18, KCNJ3, GNG13, GNG10, GNG4, GNG11, GNGT1, GNGT2, GNG3, GNG5, GNG7, HDAC5, HDAC4, DISC1, ELAVL1, UBQLN1, PLEKHG2, WDR26, GNB2L1, GNG2, RGS6, GNG12, RADIL, RAP1A, PAK1, ATXN10, RASD1, MCF2, KALRN, MCF2L, ADRBK1, PDCL, CCT5, RASD2, SPAG1, BTK, ADRB2, AVPR2, ADRA2A, MRGPRX1, TBXA2R, GNAS, ARRB1, NR3C1, GNAI1, GNAI2, GNAI3, AKT1, ATP6V1B1, GNA11, ESR1, VCAM1, NCF2, MTNR1A, SVIL, PAN2, NOL11, AFP, EPHA7, CYFIP1, GNG8, MTOR, RICTOR, RPTOR, CCDC8, ABCE1, PIK3R5, PIK3CG, COX4I1, GNAQ, NTRK1, FYN, PTK2, CEP128, XPO1, PDLIM7, SYNPO, CUL4A, GLI1, ESRRB, PIK3R1, PIK3CA, DUSP9, COX15, HSD17B10, SOD1, TRIM25, AKT2, PIK3CB |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TXN_GNB1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXN_GNB1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TXN | C0006287 | Bronchopulmonary Dysplasia | 1 | CTD_human |
| Hgene | TXN | C0011616 | Contact Dermatitis | 1 | CTD_human |
| Hgene | TXN | C0023895 | Liver diseases | 1 | CTD_human |
| Hgene | TXN | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| Hgene | TXN | C0242488 | Acute Lung Injury | 1 | CTD_human |
| Hgene | TXN | C0345967 | Malignant mesothelioma | 1 | CTD_human |
| Tgene | GNB1 | C0003469 | Anxiety Disorders | 1 | CTD_human |
| Tgene | GNB1 | C0011581 | Depressive disorder | 1 | CTD_human |
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