	FusionGeneSummary
	FusionProtFeature
	FusionGeneSequence
	FusionGenePPI
	RelatedDrugs
	RelatedDiseases

Fusion gene ID: 40219

FusionGeneSummary for TXNRD1_GNAS

Fusion gene summary

Fusion gene information	Fusion gene name: TXNRD1_GNAS
	Fusion gene ID: 40219
		Hgene	Tgene
	Gene symbol	TXNRD1	GNAS
	Gene ID	7296	2778
	Gene name	thioredoxin reductase 1	GNAS complex locus
	Synonyms	GRIM-12\|TR\|TR1\|TRXR1\|TXNR	AHO\|C20orf45\|GNAS1\|GPSA\|GSA\|GSP\|NESP\|PITA3\|POH\|SCG6\|SgVI
	Cytomap	12q23.3	20q13.32
	Type of gene	protein-coding	protein-coding
	Description	thioredoxin reductase 1, cytoplasmicKM-102-derived reductase-like factorgene associated with retinoic and IFN-induced mortality 12 proteingene associated with retinoic and interferon-induced mortality 12 proteinoxidoreductasetestis tissue sperm-bindi	protein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha
	Modification date	20180523	20180523
	UniProtAcc	Q16881	Q5JWF2
	Ensembl transtripts involved in fusion gene	ENST00000525566, ENST00000429002, ENST00000503506, ENST00000526691, ENST00000388854, ENST00000354940, ENST00000526390, ENST00000529546, ENST00000540716, ENST00000524698, ENST00000542918, ENST00000378070, ENST00000397736, ENST00000427956, ENST00000526950, ENST00000526006,	ENST00000313949, ENST00000371098, ENST00000371075, ENST00000371100, ENST00000371099, ENST00000371102, ENST00000464624, ENST00000306120, ENST00000371095, ENST00000371085, ENST00000354359, ENST00000265620, ENST00000306090, ENST00000371081,
Fusion gene scores	* DoF score	9 X 6 X 5=270	33 X 25 X 8=6600
	# samples	9	35
	** MAII score	log2(9/270*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(35/6600*10)=-4.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TXNRD1 [Title/Abstract] AND GNAS [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUSC	TCGA-51-4079-01A	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000525566	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000525566	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000525566	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000525566	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000525566	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000525566	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000429002	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000429002	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000429002	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000429002	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000429002	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000429002	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000503506	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000503506	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000503506	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000503506	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000503506	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000503506	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526691	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526691	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526691	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526691	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526691	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526691	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000388854	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000388854	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000388854	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000388854	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000388854	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000388854	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000354940	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000354940	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000354940	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000354940	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000354940	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000354940	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526390	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526390	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526390	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526390	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000526390	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000526390	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000529546	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000529546	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000529546	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000529546	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000529546	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000529546	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000540716	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000540716	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000540716	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000540716	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-3UTR	ENST00000540716	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
5UTR-intron	ENST00000540716	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000524698	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000524698	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000524698	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000524698	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000524698	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000524698	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000542918	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000542918	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000542918	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000542918	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000542918	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000542918	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000378070	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000378070	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000378070	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000378070	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000378070	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000378070	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000397736	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000397736	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000397736	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000397736	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000397736	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000397736	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000427956	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000427956	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000427956	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000427956	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000427956	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000427956	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526950	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526950	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526950	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526950	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526950	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526950	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526006	ENST00000313949	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526006	ENST00000371098	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526006	ENST00000371075	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526006	ENST00000371100	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000371099	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000371102	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-3UTR	ENST00000526006	ENST00000464624	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000306120	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000371095	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000371085	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000354359	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000265620	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000306090	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+
intron-intron	ENST00000526006	ENST00000371081	TXNRD1	chr12	104680887	+	GNAS	chr20	57470667	+

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FusionProtFeatures for TXNRD1_GNAS

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TXNRD1 Q16881	GNAS Q5JWF2
	Guanine nucleotide-binding proteins (G proteins)function as transducers in numerous signaling pathways controlledby G protein-coupled receptors (GPCRs). Signaling involves theactivation of adenylyl cyclases, resulting in increased levels ofthe signaling molecule cAMP. GNAS functions downstream of severalGPCRs, including beta-adrenergic receptors. XLas isoforms interactwith the same set of receptors as GNAS isoforms (By similarity).{ECO:0000250\|UniProtKB:Q6R0H7}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for TXNRD1_GNAS

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TXNRD1_GNAS

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
TXNRD1	GLRX2, PPP1R16A, POU2F1, POU2F2, ELAVL1, ISG15, HERC5, TP53, APEX1, TRR, TXNDC17, SF3B3, TPD52L2, DYNC1LI1, PLS3, DMRTC2, IPO5, TUBA1C, CRYZ, HSPA5, NAE1, OLA1, PAPSS2, TNPO1, TUBA4A, TUBB, UBXN1, SHFM1, RP2, PDIA6, NAPRT, TRIM25, PNPO, RPIA, THOP1, NTRK1, ESR1, TXNRD2, CDO1	GNAS	FSCN1, PAICS, RUVBL1, SHMT2, TTC1, ADCY6, CRHR1, RGS2, SNX13, VIPR1, GNAS, MDM2, CALM1, GNG2, PCK1, ADRB2, AVPR2, TBXA2R, GNB1, GNAQ, GNA11, SLC25A12, LAMTOR1, NUCB1, NUCB2, HLA-A, OPTN, PTGIR, FUS, AXIN1, PANX1, CCDC8, EGFR, JAK3, GNAL, GNG4, TRO, MAGED2, GNB2, GNB4, C1QBP, METAP2, CPT2, YBEY, GNG10, OCIAD1, GNA12, ARMCX3, GNG5, EIF4H, EML2, GIPC1, DIS3, PFAS, NTRK1, RIC8B, CHEK2, HERC2, XPO1, CAT, DBN1, FLNA, MYH9, DNAJC7, SYNPO, THOC2, ELMSAN1, ADCY2, CDC5L, CD47, GLP1R, NAP1L1, MTNR1B, TRIM25

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for TXNRD1_GNAS

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Hgene	TXNRD1	Q16881	DB01169	Arsenic trioxide	Thioredoxin reductase 1, cytoplasmic	small molecule	approved\|investigational

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RelatedDiseases for TXNRD1_GNAS

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	TXNRD1	C0001430	Adenoma	1	CTD_human
Hgene	TXNRD1	C0009404	Colorectal Neoplasms	1	CTD_human
Hgene	TXNRD1	C0011616	Contact Dermatitis	1	CTD_human
Hgene	TXNRD1	C0014544	Epilepsy	1	CTD_human
Hgene	TXNRD1	C0025500	Mesothelioma	1	CTD_human
Hgene	TXNRD1	C0029408	Degenerative polyarthritis	1	CTD_human
Hgene	TXNRD1	C0151744	Myocardial Ischemia	1	CTD_human
Hgene	TXNRD1	C0243038	Carcinoma, Lewis Lung	1	CTD_human
Tgene	GNAS	C3494506	Pseudohypoparathyroidism, Type Ia	13	CTD_human;ORPHANET;UNIPROT
Tgene	GNAS	C0242292	McCune-Albright Syndrome	5	ORPHANET;UNIPROT
Tgene	GNAS	C2931404	Albright's hereditary osteodystrophy	4	CTD_human
Tgene	GNAS	C0016065	Polyostotic fibrous dysplasia	3	CTD_human;HPO;ORPHANET
Tgene	GNAS	C0033806	Pseudohypoparathyroidism	3	CTD_human;HPO
Tgene	GNAS	C1857451	Acth-Independent Macronodular Adrenal Hyperplasia	3	ORPHANET;UNIPROT
Tgene	GNAS	C0014130	Endocrine System Diseases	2	CTD_human
Tgene	GNAS	C0034013	Precocious Puberty	2	CTD_human;HPO
Tgene	GNAS	C0221263	Cafe-au-Lait Spots	2	CTD_human
Tgene	GNAS	C0001206	Acromegaly	1	CTD_human;HPO
Tgene	GNAS	C0001624	Adrenal Gland Neoplasms	1	CTD_human
Tgene	GNAS	C0011573	Endogenous depression	1	PSYGENET
Tgene	GNAS	C0019087	Hemorrhagic Disorders	1	CTD_human
Tgene	GNAS	C0020538	Hypertensive disease	1	CTD_human;HPO
Tgene	GNAS	C0021655	Insulin Resistance	1	CTD_human
Tgene	GNAS	C0023897	Liver Diseases, Parasitic	1	CTD_human
Tgene	GNAS	C0027819	Neuroblastoma	1	CTD_human
Tgene	GNAS	C0028754	Obesity	1	CTD_human;HPO
Tgene	GNAS	C0029396	Heterotopic Ossification	1	CTD_human;HPO
Tgene	GNAS	C0032460	Polycystic Ovary Syndrome	1	CTD_human
Tgene	GNAS	C0033835	Pseudopseudohypoparathyroidism	1	CTD_human;ORPHANET
Tgene	GNAS	C0035204	Respiration Disorders	1	CTD_human
Tgene	GNAS	C0036341	Schizophrenia	1	PSYGENET
Tgene	GNAS	C0038587	Substance Withdrawal Syndrome	1	CTD_human
Tgene	GNAS	C0039231	Tachycardia	1	CTD_human
Tgene	GNAS	C0206698	Cholangiocarcinoma	1	CTD_human
Tgene	GNAS	C0221357	Brachydactyly	1	CTD_human;HPO
Tgene	GNAS	C0242184	Hypoxia	1	CTD_human
Tgene	GNAS	C0242216	Biliary calculi	1	CTD_human
Tgene	GNAS	C0334041	Osteoma cutis	1	CTD_human;ORPHANET;UNIPROT
Tgene	GNAS	C0346302	Growth Hormone-Secreting Pituitary Adenoma	1	CTD_human
Tgene	GNAS	C2932715	Pseudohypoparathyroidism Type 1B	1	CTD_human;ORPHANET
Tgene	GNAS	C2932716	Pseudohypoparathyroidism Type 1C	1	ORPHANET;UNIPROT
Tgene	GNAS	C3714756	Intellectual Disability	1	CTD_human;HPO

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Fusion gene ID: 40219

FusionGeneSummary for TXNRD1_GNAS

FusionProtFeatures for TXNRD1_GNAS

FusionGeneSequence for TXNRD1_GNAS

FusionGenePPI for TXNRD1_GNAS

RelatedDrugs for TXNRD1_GNAS

RelatedDiseases for TXNRD1_GNAS