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Fusion gene ID: 40216 |
FusionGeneSummary for TXNL4B_NR4A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TXNL4B_NR4A1 | Fusion gene ID: 40216 | Hgene | Tgene | Gene symbol | TXNL4B | NR4A1 | Gene ID | 54957 | 3164 |
| Gene name | thioredoxin like 4B | nuclear receptor subfamily 4 group A member 1 | |
| Synonyms | DLP|Dim2 | GFRP1|HMR|N10|NAK-1|NGFIB|NP10|NUR77|TR3 | |
| Cytomap | 16q22.2 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thioredoxin-like protein 4BDim1-like protein | nuclear receptor subfamily 4 group A member 1ST-59TR3 orphan receptorearly response protein NAK1growth factor-inducible nuclear protein N10hormone receptornerve growth factor IB nuclear receptor variant 1nuclear hormone receptor NUR/77orphan nucle | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | Q9NX01 | P22736 | |
| Ensembl transtripts involved in fusion gene | ENST00000268483, ENST00000423037, ENST00000426362, | ENST00000360284, ENST00000545748, ENST00000550082, ENST00000547206, ENST00000243050, ENST00000394825, ENST00000394824, ENST00000548232, | |
| Fusion gene scores | * DoF score | 6 X 6 X 1=36 | 13 X 13 X 3=507 |
| # samples | 7 | 14 | |
| ** MAII score | log2(7/36*10)=0.959358015502654 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/507*10)=-1.85655892005837 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TXNL4B [Title/Abstract] AND NR4A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NR4A1 | GO:0002042 | cell migration involved in sprouting angiogenesis | 18059339 |
| Tgene | NR4A1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 22427340 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CD517507 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000268483 | ENST00000360284 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000545748 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000550082 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000547206 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000243050 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000394825 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000394824 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000268483 | ENST00000548232 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000360284 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000545748 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000550082 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000547206 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000243050 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000394825 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000394824 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000423037 | ENST00000548232 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000360284 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000545748 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000550082 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000547206 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000243050 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000394825 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000394824 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
| intron-intron | ENST00000426362 | ENST00000548232 | TXNL4B | chr16 | 72120109 | - | NR4A1 | chr12 | 52446078 | + |
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FusionProtFeatures for TXNL4B_NR4A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TXNL4B | NR4A1 |
| Essential role in pre-mRNA splicing. Required in cellcycle progression for S/G(2) transition.{ECO:0000269|PubMed:15161931}. | Orphan nuclear receptor. May act concomitantly withNURR1 in regulating the expression of delayed-early genes duringliver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-Btransactivation of IL2. Participates in energy homeostasis bysequestrating the kinase STK11 in the nucleus, thereby attenuatingcytoplasmic AMPK activation. {ECO:0000250,ECO:0000269|PubMed:15466594, ECO:0000269|PubMed:22983157}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TXNL4B_NR4A1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TXNL4B_NR4A1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TXNL4B_NR4A1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXNL4B_NR4A1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NR4A1 | C0014175 | Endometriosis | 1 | CTD_human |
| Tgene | NR4A1 | C0021655 | Insulin Resistance | 1 | CTD_human |
| Tgene | NR4A1 | C0022658 | Kidney Diseases | 1 | CTD_human |
| Tgene | NR4A1 | C0033687 | Proteinuria | 1 | CTD_human |
| Tgene | NR4A1 | C0151744 | Myocardial Ischemia | 1 | CTD_human |
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