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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40157

FusionGeneSummary for TULP3_UGCG

check button Fusion gene summary
Fusion gene informationFusion gene name: TULP3_UGCG
Fusion gene ID: 40157
HgeneTgene
Gene symbol

TULP3

UGCG

Gene ID

7289

7357

Gene nametubby like protein 3UDP-glucose ceramide glucosyltransferase
SynonymsTUBL3GCS|GLCT1
Cytomap

12p13.33

9q31.3

Type of geneprotein-codingprotein-coding
Descriptiontubby-related protein 3ceramide glucosyltransferaseUDP-glucose:N-acylsphingosine D-glucosyltransferaseglucosylceramide synthase
Modification date2018052320180523
UniProtAcc

O75386

Q16739

Ensembl transtripts involved in fusion geneENST00000448120, ENST00000397132, 
ENST00000374279, ENST00000495085, 
Fusion gene scores* DoF score8 X 5 X 6=2404 X 2 X 4=32
# samples 74
** MAII scorelog2(7/240*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TULP3 [Title/Abstract] AND UGCG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTULP3

GO:0008277

regulation of G-protein coupled receptor protein signaling pathway

20889716

HgeneTULP3

GO:0045879

negative regulation of smoothened signaling pathway

20889716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-DX-A1KZ-01ATULP3chr12

3043727

+UGCGchr9

114676885

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000448120ENST00000374279TULP3chr12

3043727

+UGCGchr9

114676885

+
5CDS-3UTRENST00000448120ENST00000495085TULP3chr12

3043727

+UGCGchr9

114676885

+
Frame-shiftENST00000397132ENST00000374279TULP3chr12

3043727

+UGCGchr9

114676885

+
5CDS-3UTRENST00000397132ENST00000495085TULP3chr12

3043727

+UGCGchr9

114676885

+

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FusionProtFeatures for TULP3_UGCG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TULP3

O75386

UGCG

Q16739

Negative regulator of the Shh signaling transductionpathway: recruited to primary cilia via association with the IFTcomplex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependentbasal repression machinery in Shh signaling. Binds tophosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required toregulate ciliary G protein-coupled receptor trafficking. Notinvolved in ciliogenesis. {ECO:0000269|PubMed:11375483,ECO:0000269|PubMed:20889716}. Catalyzes the first glycosylation step inglycosphingolipid biosynthesis, the transfer of glucose toceramide. May also serve as a "flippase".{ECO:0000269|PubMed:8643456}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TULP3_UGCG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TULP3_UGCG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TULP3SIRT1, MAGEA6, PSTPIP1, ROPN1, ANKRD54, KRTAP10-7, KRTAP10-1, KRTAP10-5, CTDSPL, TTC21B, WDR35, LYSMD1, WDR19, IFT43, IFT140, ARIH1, FOXK2, IFT122, GNL1, KANSL2, BCR, PDLIM5, FOXK1, ARIH2, MCRS1, PML, PPP1R12A, PHKB, DCAF16, RAD18, NUMB, PIP4K2C, CAV3, GGPS1, USP7, WAPAL, KBTBD7, OBSL1, RNF138, PIP4K2B, MTMR3, THNSL1, MAPK9, TUB, PARN, JMJD6, KLHL42, ANKHD1, MAPK3, BACH2, DPH1, GTF2I, RALB, EXOC3UGCGRTN1, RTN3, APP, TSPAN3, TMEM231, TNFRSF10B, HEPACAM2, PICK1, CHMP4B, C16orf58, TNFRSF10A, CD83, MRAP2, SLC20A1, PTGIR, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TULP3_UGCG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneUGCGQ16739DB00419MiglustatCeramide glucosyltransferasesmall moleculeapproved
TgeneUGCGQ16739DB09039EliglustatCeramide glucosyltransferasesmall moleculeapproved

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RelatedDiseases for TULP3_UGCG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneUGCGC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneUGCGC0151744Myocardial Ischemia1CTD_human