FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 40149

FusionGeneSummary for TUG1_TUG1

check button Fusion gene summary
Fusion gene informationFusion gene name: TUG1_TUG1
Fusion gene ID: 40149
HgeneTgene
Gene symbol

TUG1

TUG1

Gene ID

55000

55000

Gene nametaurine up-regulated 1taurine up-regulated 1
SynonymsLINC00080|NCRNA00080|TI-227HLINC00080|NCRNA00080|TI-227H
Cytomap

22q12.2

22q12.2

Type of genencRNAncRNA
DescriptionTUG1 noncoding RNAlong intergenic non-protein coding RNA 80taurine up-regulated 1 (non-protein coding)taurine upregulated gene 1TUG1 noncoding RNAlong intergenic non-protein coding RNA 80taurine up-regulated 1 (non-protein coding)taurine upregulated gene 1
Modification date2018052020180520
UniProtAcc

Ensembl transtripts involved in fusion geneENST00000540687, ENST00000566220, 
ENST00000519077, ENST00000521091, 
ENST00000569149, ENST00000563812, 
ENST00000602393, ENST00000602971, 
ENST00000569384, 
ENST00000540687, 
ENST00000566220, ENST00000519077, 
ENST00000521091, ENST00000569149, 
ENST00000563812, ENST00000602393, 
ENST00000602971, ENST00000569384, 
Fusion gene scores* DoF score4 X 4 X 1=162 X 2 X 2=8
# samples 42
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: TUG1 [Title/Abstract] AND TUG1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA742852TUG1chr22

31373340

+TUG1chr22

31373466

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000540687ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000540687ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-3UTRENST00000540687ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000540687ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000540687ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000540687ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000540687ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000540687ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000540687ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000566220ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000566220ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-3UTRENST00000566220ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000566220ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000566220ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000566220ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000566220ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000566220ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000566220ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-intronENST00000519077ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-intronENST00000519077ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-3UTRENST00000519077ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-intronENST00000519077ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-intronENST00000519077ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-intronENST00000519077ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-intronENST00000519077ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-intronENST00000519077ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
3UTR-intronENST00000519077ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000521091ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000521091ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-3UTRENST00000521091ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000521091ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000521091ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000521091ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000521091ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000521091ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000521091ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569149ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569149ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-3UTRENST00000569149ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569149ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569149ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569149ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569149ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569149ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569149ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000563812ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000563812ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-3UTRENST00000563812ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000563812ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000563812ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000563812ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000563812ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000563812ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000563812ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602393ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602393ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-3UTRENST00000602393ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602393ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602393ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602393ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602393ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602393ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602393ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602971ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602971ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-3UTRENST00000602971ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602971ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602971ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602971ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602971ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602971ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000602971ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569384ENST00000540687TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569384ENST00000566220TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-3UTRENST00000569384ENST00000519077TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569384ENST00000521091TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569384ENST00000569149TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569384ENST00000563812TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569384ENST00000602393TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569384ENST00000602971TUG1chr22

31373340

+TUG1chr22

31373466

-
intron-intronENST00000569384ENST00000569384TUG1chr22

31373340

+TUG1chr22

31373466

-

Top

FusionProtFeatures for TUG1_TUG1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUG1

TUG1

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TUG1_TUG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TUG1_TUG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TUG1_TUG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TUG1_TUG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource