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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40147

FusionGeneSummary for TUG1_MGAT5

check button Fusion gene summary
Fusion gene informationFusion gene name: TUG1_MGAT5
Fusion gene ID: 40147
HgeneTgene
Gene symbol

TUG1

MGAT5

Gene ID

55000

4249

Gene nametaurine up-regulated 1mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
SynonymsLINC00080|NCRNA00080|TI-227HGNT-V|GNT-VA
Cytomap

22q12.2

2q21.2-q21.3

Type of genencRNAprotein-coding
DescriptionTUG1 noncoding RNAlong intergenic non-protein coding RNA 80taurine up-regulated 1 (non-protein coding)taurine upregulated gene 1alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase AN-acetylglucosaminyl-transferase Valpha-mannoside beta-1,6-N-acetylglucosaminyltransferaseglcNAc-T Vmannoside acetylglucosaminyltransferase 5
Modification date2018052020180523
UniProtAcc

Q09328

Ensembl transtripts involved in fusion geneENST00000540687, ENST00000566220, 
ENST00000519077, ENST00000521091, 
ENST00000569149, ENST00000563812, 
ENST00000602393, ENST00000602971, 
ENST00000569384, 
ENST00000468758, 
ENST00000409645, ENST00000281923, 
Fusion gene scores* DoF score4 X 4 X 1=165 X 5 X 3=75
# samples 45
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUG1 [Title/Abstract] AND MGAT5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF088006TUG1chr22

31372180

+MGAT5chr2

135156105

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000540687ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000540687ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000540687ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000566220ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000566220ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000566220ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-
3UTR-intronENST00000519077ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
3UTR-intronENST00000519077ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
3UTR-intronENST00000519077ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000521091ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000521091ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000521091ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000569149ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000569149ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000569149ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000563812ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000563812ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000563812ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000602393ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000602393ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000602393ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000602971ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000602971ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000602971ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000569384ENST00000468758TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000569384ENST00000409645TUG1chr22

31372180

+MGAT5chr2

135156105

-
intron-intronENST00000569384ENST00000281923TUG1chr22

31372180

+MGAT5chr2

135156105

-

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FusionProtFeatures for TUG1_MGAT5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUG1

MGAT5

Q09328

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linkedoligosaccharides. It is one of the most important enzymes involvedin the regulation of the biosynthesis of glycoproteinoligosaccharides.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUG1_MGAT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUG1_MGAT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUG1_MGAT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUG1_MGAT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMGAT5C0023893Liver Cirrhosis, Experimental1CTD_human