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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40133

FusionGeneSummary for TUBGCP5_KCNU1

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBGCP5_KCNU1
Fusion gene ID: 40133
HgeneTgene
Gene symbol

TUBGCP5

KCNU1

Gene ID

114791

157855

Gene nametubulin gamma complex associated protein 5potassium calcium-activated channel subfamily U member 1
SynonymsGCP5KCNMC1|KCa5|KCa5.1|Kcnma3|Slo3
Cytomap

15q11.2

8p11.23

Type of geneprotein-codingprotein-coding
Descriptiongamma-tubulin complex component 5gamma-tubulin complex component GCP5potassium channel subfamily U member 1Calcium-activated potassium channel subunit alpha-3Calcium-activated potassium channel, subfamily M subunit alpha-3Slowpoke homolog 3potassium channel, subfamily U, member 1
Modification date2018052320180523
UniProtAcc

Q96RT8

A8MYU2

Ensembl transtripts involved in fusion geneENST00000283645, ENST00000453949, 
ENST00000559846, 
ENST00000399881, 
ENST00000518904, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 4 X 7=196
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/196*10)=-1.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUBGCP5 [Title/Abstract] AND KCNU1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTUBGCP5

GO:0007020

microtubule nucleation

11694571


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVREADTCGA-CL-5917-01ATUBGCP5chr15

22872499

+KCNU1chr8

36763226

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000283645ENST00000399881TUBGCP5chr15

22872499

+KCNU1chr8

36763226

+
5CDS-intronENST00000283645ENST00000518904TUBGCP5chr15

22872499

+KCNU1chr8

36763226

+
Frame-shitENST00000453949ENST00000399881TUBGCP5chr15

22872499

+KCNU1chr8

36763226

+
5CDS-intronENST00000453949ENST00000518904TUBGCP5chr15

22872499

+KCNU1chr8

36763226

+
intron-3CDSENST00000559846ENST00000399881TUBGCP5chr15

22872499

+KCNU1chr8

36763226

+
intron-intronENST00000559846ENST00000518904TUBGCP5chr15

22872499

+KCNU1chr8

36763226

+

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FusionProtFeatures for TUBGCP5_KCNU1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUBGCP5

Q96RT8

KCNU1

A8MYU2

Gamma-tubulin complex is necessary for microtubulenucleation at the centrosome. Testis-specific potassium channel activated by bothintracellular pH and membrane voltage that mediates export ofK(+). May represent the primary spermatozoan K(+) current. Incontrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+).Critical for fertility. May play an important role in spermosmoregulation required for the acquisition of normal morphologyand motility when faced with osmotic challenges, such as thoseexperienced after mixing with seminal fluid and entry into thevagina. {ECO:0000269|PubMed:23129643}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUBGCP5_KCNU1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUBGCP5_KCNU1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TUBGCP5UBC, CDK5RAP2, TUBG1, TUBGCP3, TUBGCP2, MZT2B, NTRK1, CLU, ALDH18A1, DNAJC6, DAPK2, TUBGCP4, NME7, PLEKHG1, TUBGCP6, SCAF11, NEDD1, MZT1, MZT2A, TUBG2, TXNDC12, LGALS3BP, BTRC, RICTOR, TMEM186, ASPM, CD2BP2KCNU1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUBGCP5_KCNU1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TUBGCP5_KCNU1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource