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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4012

FusionGeneSummary for BCL2L10_GNB5

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL2L10_GNB5
Fusion gene ID: 4012
HgeneTgene
Gene symbol

BCL2L10

GNB5

Gene ID

10017

10681

Gene nameBCL2 like 10G protein subunit beta 5
SynonymsBCL-B|Boo|Diva|bcl2-L-10GB5|IDDCA|LADCI
Cytomap

15q21.2

15q21.2

Type of geneprotein-codingprotein-coding
Descriptionbcl-2-like protein 10BCL2-like 10 (apoptosis facilitator)anti-apoptotic protein NrHapoptosis regulator Bcl-Bdeath inducer binding to vBcl-2 and Apaf-1guanine nucleotide-binding protein subunit beta-5G protein, beta subunit 5Lgbeta5guanine nucleotide binding protein (G protein), beta 5guanine nucleotide-binding protein, beta subunit 5Ltransducin beta chain 5
Modification date2018052320180519
UniProtAcc

Q9HD36

O14775

Ensembl transtripts involved in fusion geneENST00000260442, ENST00000561198, 
ENST00000261837, ENST00000396335, 
ENST00000358784, ENST00000559348, 
ENST00000560116, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: BCL2L10 [Title/Abstract] AND GNB5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCL2L10

GO:0043066

negative regulation of apoptotic process

11278245

TgeneGNB5

GO:0007212

dopamine receptor signaling pathway

27677260

TgeneGNB5

GO:0043547

positive regulation of GTPase activity

10521509

TgeneGNB5

GO:1901386

negative regulation of voltage-gated calcium channel activity

11007869|12606627


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-EA-A3QD-01ABCL2L10chr15

52404435

-GNB5chr15

52446273

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000260442ENST00000261837BCL2L10chr15

52404435

-GNB5chr15

52446273

-
Frame-shiftENST00000260442ENST00000396335BCL2L10chr15

52404435

-GNB5chr15

52446273

-
Frame-shiftENST00000260442ENST00000358784BCL2L10chr15

52404435

-GNB5chr15

52446273

-
5CDS-intronENST00000260442ENST00000559348BCL2L10chr15

52404435

-GNB5chr15

52446273

-
5CDS-intronENST00000260442ENST00000560116BCL2L10chr15

52404435

-GNB5chr15

52446273

-
intron-3CDSENST00000561198ENST00000261837BCL2L10chr15

52404435

-GNB5chr15

52446273

-
intron-3CDSENST00000561198ENST00000396335BCL2L10chr15

52404435

-GNB5chr15

52446273

-
intron-3CDSENST00000561198ENST00000358784BCL2L10chr15

52404435

-GNB5chr15

52446273

-
intron-intronENST00000561198ENST00000559348BCL2L10chr15

52404435

-GNB5chr15

52446273

-
intron-intronENST00000561198ENST00000560116BCL2L10chr15

52404435

-GNB5chr15

52446273

-

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FusionProtFeatures for BCL2L10_GNB5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL2L10

Q9HD36

GNB5

O14775

Promotes cell survival. Suppresses apoptosis induced byBAX but not BAK. {ECO:0000269|PubMed:11278245}. Enhances GTPase-activating protein (GAP) activity ofregulator of G protein signaling (RGS) proteins, hence involved inthe termination of the signaling initiated by the G proteincoupled receptors (GPCRs) by accelerating the GTP hydrolysis onthe G-alpha subunits, thereby promoting their inactivation(Probable). Increases RGS9 GTPase-activating protein (GAP)activity, hence contributes to the deactivation of G proteinsignaling initiated by D(2) dopamine receptors (PubMed:27677260).May play an important role in neuronal signaling, including in theparasympathetic, but not sympathetic, control of heart rate (Bysimilarity). {ECO:0000250|UniProtKB:A1L271,ECO:0000269|PubMed:27677260, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BCL2L10_GNB5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BCL2L10_GNB5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BCL2L10BCL2L10, BCL2, BAX, UBQLN1, NR4A1, CASP8GNB5GNG5, GNG4, GNG3, GNG7, MVD, MCM2, RGS7, GNG13, RGS6, BNIP3L, CSNK2B, CDKN1A, ANXA7, TSC22D1, ELAVL1, RGS7BP, GNG2, RGS11, PDCL, CCT5, RGS9, APP, PSMD4, E2F2, RPA1, MTOR, USP38, CCT6B, CCT3, TCP1, PFDN5, COPS5, CUL4A, DRD2, PRPF40B, CCT2, CCT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BCL2L10_GNB5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BCL2L10_GNB5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource