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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 4011

FusionGeneSummary for BCL11B_MIPOL1

check button Fusion gene summary
Fusion gene informationFusion gene name: BCL11B_MIPOL1
Fusion gene ID: 4011
HgeneTgene
Gene symbol

BCL11B

MIPOL1

Gene ID

64919

145282

Gene nameB cell CLL/lymphoma 11Bmirror-image polydactyly 1
SynonymsATL1|ATL1-alpha|ATL1-beta|ATL1-delta|ATL1-gamma|CTIP-2|CTIP2|IMD49|RIT1|ZNF856B|hRIT1-alphaCCDC193
Cytomap

14q32.2

14q13.3-q21.1

Type of geneprotein-codingprotein-coding
DescriptionB-cell lymphoma/leukemia 11BB-cell CLL/lymphoma 11B (zinc finger protein)B-cell CLL/lymphoma 11B/T-cell receptor delta constant region fusion proteinB-cell lymphoma/leukaemia 11BBCL-11BBCL11B/TRDC fusionCOUP-TF-interacting protein 2hRit1radiation-mirror-image polydactyly gene 1 protein
Modification date2018052320180519
UniProtAcc

Q9C0K0

Q8TD10

Ensembl transtripts involved in fusion geneENST00000357195, ENST00000345514, 
ENST00000443726, 		ENST00000536774, 
ENST00000327441, ENST00000539062, 
ENST00000556451, ENST00000396294, 
ENST00000545536, ENST00000537471, 
ENST00000539174, 
Fusion gene scores* DoF score4 X 5 X 2=409 X 7 X 7=441
# samples 159
** MAII scorelog2(15/40*10)=1.90689059560852
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/441*10)=-2.29278174922785
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCL11B [Title/Abstract] AND MIPOL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-C4-A0F7-01ABCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357195ENST00000536774BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-intronENST00000357195ENST00000327441BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-intronENST00000357195ENST00000539062BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-5UTRENST00000357195ENST00000556451BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-5UTRENST00000357195ENST00000396294BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-5UTRENST00000357195ENST00000545536BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-5UTRENST00000357195ENST00000537471BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-intronENST00000357195ENST00000539174BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-intronENST00000345514ENST00000536774BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-intronENST00000345514ENST00000327441BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-intronENST00000345514ENST00000539062BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-5UTRENST00000345514ENST00000556451BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-5UTRENST00000345514ENST00000396294BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-5UTRENST00000345514ENST00000545536BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-5UTRENST00000345514ENST00000537471BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
5CDS-intronENST00000345514ENST00000539174BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
intron-intronENST00000443726ENST00000536774BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
intron-intronENST00000443726ENST00000327441BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
intron-intronENST00000443726ENST00000539062BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
intron-5UTRENST00000443726ENST00000556451BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
intron-5UTRENST00000443726ENST00000396294BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
intron-5UTRENST00000443726ENST00000545536BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
intron-5UTRENST00000443726ENST00000537471BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+
intron-intronENST00000443726ENST00000539174BCL11Bchr14

99723808

-MIPOL1chr14

37688758

+

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FusionProtFeatures for BCL11B_MIPOL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCL11B

Q9C0K0

MIPOL1

Q8TD10

Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential incontrolling the responsiveness of hematopoietic stem cells tochemotactic signals by modulating the expression of the receptorsCCR7 and CCR9, which direct the movement of progenitor cells fromthe bone marrow to the thymus (PubMed:27959755). Is a regulator ofIL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor that repressestranscription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in theP53-signaling pathway (By similarity).{ECO:0000250|UniProtKB:Q99PV8, ECO:0000269|PubMed:16809611,ECO:0000269|PubMed:27959755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BCL11B_MIPOL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BCL11B_MIPOL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BCL11BNR2F1, CHD4, MTA2, MTA1, RBBP7, RBBP4, HDAC2, HDAC1, MBD3, SP1, CBX5, HDAC3, SUV39H1, NOTCH1, HDAC6, NFATC1, NFATC2MIPOL1LATS2, ARNT2, DGCR6, ATP5O, BYSL, CKS1B, UBE2K, MAGEA6, MCM7, MFAP1, CDK18, SMARCE1, CCT3, EIF4E2, USH1C, SSX3, NEBL, PPP1R13B, PRPF31, DIEXF, MYLIP, TTC12, RBM41, RCOR3, SCNM1, CCDC33, ENKD1, FAM161A, TCHP, ZGPAT, BEX2, FBF1, EAF1, HAUS1, MIPOL1, RTP5, LRRC39, SRPK2, DUSP13, RGS2, ZNF408, CCDC172, SH3BP5L, TSPYL4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BCL11B_MIPOL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BCL11B_MIPOL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBCL11BC0024299Lymphoma1CTD_human
HgeneBCL11BC1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneMIPOL1C0152427Polydactyly1CTD_human