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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40109

FusionGeneSummary for TUBB_SCD

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBB_SCD
Fusion gene ID: 40109
HgeneTgene
Gene symbol

TUBB

SCD

Gene ID

203068

6319

Gene nametubulin beta class Istearoyl-CoA desaturase
SynonymsCDCBM6|CSCSC1|M40|OK/SW-cl.56|TUBB1|TUBB5FADS5|MSTP008|SCD1|SCDOS|hSCD1
Cytomap

6p21.33

10q24.31

Type of geneprotein-codingprotein-coding
Descriptiontubulin beta chainbeta Ib tubulintubulin beta-1 chaintubulin beta-5 chaintubulin, beta polypeptideacyl-CoA desaturasedelta(9)-desaturasefatty acid desaturasepredicted protein of HQ0998stearoyl-CoA desaturase (delta-9-desaturase)stearoyl-CoA desaturase opposite strand
Modification date2018052320180523
UniProtAcc

P07437

O00767

Ensembl transtripts involved in fusion geneENST00000327892, ENST00000435534, 
ENST00000330914, ENST00000396389, 
ENST00000396384, ENST00000421473, 
ENST00000549614, ENST00000413547, 
ENST00000419551, ENST00000454620, 
ENST00000422674, ENST00000548023, 
ENST00000435546, ENST00000420400, 
ENST00000453350, ENST00000419792, 
ENST00000547690, ENST00000436335, 
ENST00000425136, ENST00000444441, 
ENST00000422650, ENST00000547695, 
ENST00000454454, ENST00000412136, 
ENST00000446385, ENST00000383564, 
ENST00000551208, ENST00000400531, 
ENST00000400534, ENST00000400530, 
ENST00000436628, ENST00000549902, 
ENST00000437490, ENST00000426754, 
ENST00000425102, ENST00000432462, 
ENST00000549654, ENST00000427480, 
ENST00000424734, ENST00000420618, 
ENST00000370355, 
Fusion gene scores* DoF score4 X 4 X 3=487 X 7 X 3=147
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/147*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TUBB [Title/Abstract] AND SCD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTUBB

GO:0009987

cellular process

19567321

TgeneSCD

GO:0006636

unsaturated fatty acid biosynthetic process

15907797|18765284


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE695571TUBBchr6

2025100

+SCDchr10

102120708

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000327892ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000435534ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000330914ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000396389ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000396384ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000421473ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000549614ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000413547ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000419551ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000454620ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000422674ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000548023ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000435546ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000420400ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000453350ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000419792ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000547690ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000436335ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000425136ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000444441ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000422650ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000547695ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000454454ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000412136ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000446385ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000383564ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000551208ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000400531ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000400534ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000400530ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000436628ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000549902ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000437490ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000426754ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000425102ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
3UTR-3UTRENST00000432462ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
intron-3UTRENST00000549654ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
3UTR-3UTRENST00000427480ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
3UTR-3UTRENST00000424734ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+
3UTR-3UTRENST00000420618ENST00000370355TUBBchr6

2025100

+SCDchr10

102120708

+

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FusionProtFeatures for TUBB_SCD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUBB

P07437

SCD

O00767

Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUBB_SCD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUBB_SCD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUBB_SCD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTUBBP07437DB00570VinblastineTubulin beta chainsmall moleculeapproved
HgeneTUBBP07437DB01179PodofiloxTubulin beta chainsmall moleculeapproved
HgeneTUBBP07437DB01394ColchicineTubulin beta chainsmall moleculeapproved
HgeneTUBBP07437DB00361VinorelbineTubulin beta chainsmall moleculeapproved|investigational
HgeneTUBBP07437DB00541VincristineTubulin beta chainsmall moleculeapproved|investigational
HgeneTUBBP07437DB11638ArtenimolTubulin beta chainsmall moleculeapproved|investigational

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RelatedDiseases for TUBB_SCD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTUBBC0473586Michelin tire baby syndrome1ORPHANET;UNIPROT
HgeneTUBBC4014283CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 61UNIPROT
TgeneSCDC0024667Animal Mammary Neoplasms2CTD_human
TgeneSCDC0024668Mammary Neoplasms, Experimental2CTD_human
TgeneSCDC0023794Lipoidosis1CTD_human
TgeneSCDC0023903Liver neoplasms1CTD_human
TgeneSCDC0339143Thyroid associated opthalmopathies1CTD_human
TgeneSCDC2239176Liver carcinoma1CTD_human