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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40097

FusionGeneSummary for TUBB3_TRPM5

check button Fusion gene summary
Fusion gene informationFusion gene name: TUBB3_TRPM5
Fusion gene ID: 40097
HgeneTgene
Gene symbol

TUBB3

TRPM5

Gene ID

10381

29850

Gene nametubulin beta 3 class IIItransient receptor potential cation channel subfamily M member 5
SynonymsCDCBM|CDCBM1|CFEOM3|CFEOM3A|FEOM3|TUBB4|beta-4LTRPC5|MTR1
Cytomap

16q24.3

11p15.5

Type of geneprotein-codingprotein-coding
Descriptiontubulin beta-3 chainclass III beta-tubulintubulin beta-4 chaintubulin beta-IIItubulin, beta 3transient receptor potential cation channel subfamily M member 5LTrpC-5MLSN1 and TRP-relatedMLSN1- and TRP-related gene 1 proteinlong transient receptor potential channel 5
Modification date2018052320180329
UniProtAcc

Q13509

Q9NZQ8

Ensembl transtripts involved in fusion geneENST00000556922, ENST00000554444, 
ENST00000315491, ENST00000554116, 
ENST00000555576, ENST00000554336, 
ENST00000553967, ENST00000304984, 
ENST00000155858, ENST00000452833, 
ENST00000533060, ENST00000528453, 
Fusion gene scores* DoF score3 X 2 X 3=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: TUBB3 [Title/Abstract] AND TRPM5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-V1-A9ZI-01ATUBB3chr16

89989866

+TRPM5chr11

2439821

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000556922ENST00000155858TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000556922ENST00000452833TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000556922ENST00000533060TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000556922ENST00000528453TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000554444ENST00000155858TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000554444ENST00000452833TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000554444ENST00000533060TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000554444ENST00000528453TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000315491ENST00000155858TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000315491ENST00000452833TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000315491ENST00000533060TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000315491ENST00000528453TUBB3chr16

89989866

+TRPM5chr11

2439821

-
3UTR-3CDSENST00000554116ENST00000155858TUBB3chr16

89989866

+TRPM5chr11

2439821

-
3UTR-3CDSENST00000554116ENST00000452833TUBB3chr16

89989866

+TRPM5chr11

2439821

-
3UTR-3CDSENST00000554116ENST00000533060TUBB3chr16

89989866

+TRPM5chr11

2439821

-
3UTR-3CDSENST00000554116ENST00000528453TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000555576ENST00000155858TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000555576ENST00000452833TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000555576ENST00000533060TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000555576ENST00000528453TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000554336ENST00000155858TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000554336ENST00000452833TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000554336ENST00000533060TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000554336ENST00000528453TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000553967ENST00000155858TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000553967ENST00000452833TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000553967ENST00000533060TUBB3chr16

89989866

+TRPM5chr11

2439821

-
Frame-shiftENST00000553967ENST00000528453TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000304984ENST00000155858TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000304984ENST00000452833TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000304984ENST00000533060TUBB3chr16

89989866

+TRPM5chr11

2439821

-
intron-3CDSENST00000304984ENST00000528453TUBB3chr16

89989866

+TRPM5chr11

2439821

-

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FusionProtFeatures for TUBB3_TRPM5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TUBB3

Q13509

TRPM5

Q9NZQ8

Tubulin is the major constituent of microtubules. Itbinds two moles of GTP, one at an exchangeable site on the betachain and one at a non-exchangeable site on the alpha chain. TUBB3plays a critical role in proper axon guidance and mantainance.{ECO:0000269|PubMed:20074521}. Voltage-modulated Ca(2+)-activated, monovalent cationchannel (VCAM) that mediates a transient membrane depolarizationand plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transportof Na(+), K(+) and Cs(+) ions equally well. Activated directly byincreases in intracellular Ca(2+), but is impermeable to it.Gating is voltage-dependent and displays rapid activation anddeactivation kinetics upon channel stimulation even duringsustained elevations in Ca(2+). Also activated by a fastintracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blockedby extracellular acidification. External acidification has 2effects, a fast reversible block of the current and a slowerirreversible enhancement of current inactivation. Is a highlytemperature-sensitive, heat activated channel showing a steepincrease of inward currents at temperatures between 15 and 35degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated byarachidonic acid in vitro. May be involved in perception ofbitter, sweet and umami tastes. May also be involved in sensingsemiochemicals. {ECO:0000269|PubMed:14634208}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TUBB3_TRPM5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TUBB3_TRPM5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TUBB3SPTSSA, INSM1, SEL1L3, LAPTM4A, MRPL28, PHIP, ROBO1, ARHGEF7, GABARAP, RILPL2, DDX39B, HEXDC, KHDRBS1, TF, EEF1G, STAU1, TK1, CDKN1A, SMN1, RCC1, ANXA7, PLK1, LIN37, ELAVL1, ARRB2, SP1, FBXO25, TERF1, CUL3, DYNC1I1, INPPL1, SHC1, CRK, AP2M1, LMAN1, TUBA4A, TUBA1A, TUBA1B, TUBA1C, MDN1, GZMK, IQCB1, PEX14, CAMKMT, FAM86B2, METTL21B, VCPKMT, METTL22, METTL23, CD81, NPM1, SOX2, HDAC6, EGFR, TPTE, FBXO6, ACAT2, CAPZA1, CAPZB, MSN, STK26, PAPSS1, RARS, VCL, ASB4, ASB8, ASB17, ASB18, MAPT, CEP250, HAUS2, EMD, EML1, MTCL1, CCAR2, FCGR3B, KLK11, KLK5, SPACA1, ANTXR1, FAS, PLAUR, EIF3F, IL12RB1, PRKCSH, TUBB2B, ISLR, SCN2B, THBS3, PRG2, CDK13, RPS6KB2, AMBRA1, TNPO1, VCP, NTRK1, PTEN, HERC2, XPO1, HNRNPD, SYNCRIP, BAG6, GAN, ALKBH3, APPL1, MCM2, MCM5, PIWIL1, STMN1, SNW1, FAF2, POU5F1, MAP7D3, CA5A, ABCC2, DLGAP5, EML6, TUBB1, EML2, TPSB2, TUBB, LRP1, C1orf85, TTC5, RPL28, DOCK5, DNASE2B, XCL1, EML4, LAMP3, CLEC4E, TMEM108, FAM174A, CHRM4, GML, LGALS7, SLAMF1, EFNB3, TSPYL6, FAM196A, GDF9, WNT7A, ST8SIA4, STK16, INSL5, SALL2, CCL22, IQCF1, AIFM1, RNF19B, TMCO3, ADAMTS4, PRG3, TUBB2A, CDH13, CD79A, CENPJ, NPAS1, MUC20, SNX21, TCP11L1, CHRM3, ENPP7, TAF5L, TOR1AIP2, PRSS50, DEF8, VSIG1, WNT16, APLNR, SKP2, TSHB, EEF1D, TOMM22, CBWD1, AVIL, F9, SLCO1B1, HS3ST2, XAGE1B, P2RX2, ZNF695, SLC5A5, CD79B, KLK6, SUSD4, PRSS2, MAPK8IP1, TMEM25, NRG1, SIRT6, PROZ, PDDC1, PCDH20, C9orf3, DDX39A, BPNT1, TRAC, DKKL1, RPS27, PPARD, PLA2G10, CYLD, TRIM25, G3BP1, HEY1, BRCA1, TESTRPM5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TUBB3_TRPM5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTUBB3Q13509DB04845IxabepiloneTubulin beta-3 chainsmall moleculeapproved|investigational

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RelatedDiseases for TUBB3_TRPM5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTUBB3C0919267ovarian neoplasm1CTD_human
HgeneTUBB3C1458155Mammary Neoplasms1CTD_human
HgeneTUBB3C2748801FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 3A, WITH OR WITHOUT EXTRAOCULAR INVOLVEMENT1CTD_human;UNIPROT
HgeneTUBB3C3808397CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 11ORPHANET;UNIPROT