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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40052

FusionGeneSummary for TTL_GPC3

check button Fusion gene summary
Fusion gene informationFusion gene name: TTL_GPC3
Fusion gene ID: 40052
HgeneTgene
Gene symbol

TTL

GPC3

Gene ID

150465

2719

Gene nametubulin tyrosine ligaseglypican 3
Synonyms-DGSX|GTR2-2|MXR7|OCI-5|SDYS|SGB|SGBS|SGBS1
Cytomap

2q14.1

Xq26.2

Type of geneprotein-codingprotein-coding
Descriptiontubulin--tyrosine ligase2410003M22Rikglypican-3glypican proteoglycan 3heparan sulphate proteoglycanintestinal protein OCI-5secreted glypican-3
Modification date2018051920180527
UniProtAcc

Q8NG68

P51654

Ensembl transtripts involved in fusion geneENST00000233336, ENST00000460450, 
ENST00000370818, ENST00000394299, 
ENST00000543339, 
Fusion gene scores* DoF score2 X 2 X 1=47 X 6 X 4=168
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTL [Title/Abstract] AND GPC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC036707TTLchr2

113289983

+GPC3chrX

132690986

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000233336ENST00000370818TTLchr2

113289983

+GPC3chrX

132690986

-
3UTR-intronENST00000233336ENST00000394299TTLchr2

113289983

+GPC3chrX

132690986

-
3UTR-intronENST00000233336ENST00000543339TTLchr2

113289983

+GPC3chrX

132690986

-
5CDS-intronENST00000460450ENST00000370818TTLchr2

113289983

+GPC3chrX

132690986

-
5CDS-intronENST00000460450ENST00000394299TTLchr2

113289983

+GPC3chrX

132690986

-
5CDS-intronENST00000460450ENST00000543339TTLchr2

113289983

+GPC3chrX

132690986

-

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FusionProtFeatures for TTL_GPC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTL

Q8NG68

GPC3

P51654

Catalyzes the post-translational addition of a tyrosineto the C-terminal end of detyrosinated alpha-tubulin.{ECO:0000269|PubMed:25908662}. Cell surface proteoglycan that bears heparan sulfate.Inhibits the dipeptidyl peptidase activity of DPP4. May beinvolved in the suppression/modulation of growth in thepredominantly mesodermal tissues and organs. May play a role inthe modulation of IGF2 interactions with its receptor and therebymodulate its function. May regulate growth and tumorpredisposition. {ECO:0000269|PubMed:17549790}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTL_GPC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTL_GPC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTL_GPC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTL_GPC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGPC3C0025500Mesothelioma1CTD_human
TgeneGPC3C0796154SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 11CTD_human;ORPHANET;UNIPROT
TgeneGPC3C2239176Liver carcinoma1CTD_human