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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40044

FusionGeneSummary for TTLL6_WRAP53

check button Fusion gene summary
Fusion gene informationFusion gene name: TTLL6_WRAP53
Fusion gene ID: 40044
HgeneTgene
Gene symbol

TTLL6

WRAP53

Gene ID

284076

55135

Gene nametubulin tyrosine ligase like 6WD repeat containing antisense to TP53
SynonymsTTL.6DKCB3|TCAB1|WDR79
Cytomap

17q21.32

17p13.1

Type of geneprotein-codingprotein-coding
Descriptiontubulin polyglutamylase TTLL6tubulin tyrosine ligase-like family member 6tubulin--tyrosine ligase-like protein 6telomerase Cajal body protein 1WD repeat-containing protein 79WD repeat-containing protein WRAP53WD40 protein Wrap53WD40 repeat-containing protein antisense to TP53WD40 repeat-containing protein encoding RNA antisense to p53
Modification date2018051920180519
UniProtAcc

Q8N841

Q9BUR4

Ensembl transtripts involved in fusion geneENST00000433608, ENST00000393382, 
ENST00000470462, 
ENST00000431639, 
ENST00000316024, ENST00000457584, 
ENST00000396463, ENST00000534050, 
Fusion gene scores* DoF score2 X 2 X 2=89 X 4 X 5=180
# samples 29
** MAII scorelog2(2/8*10)=1.32192809488736log2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTLL6 [Title/Abstract] AND WRAP53 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWRAP53

GO:0007004

telomere maintenance via telomerase

23685356

TgeneWRAP53

GO:0051973

positive regulation of telomerase activity

19179534|23685356


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-A6-5657-01ATTLL6chr17

46893201

-WRAP53chr17

7590695

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000433608ENST00000431639TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-5UTRENST00000433608ENST00000316024TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000433608ENST00000457584TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000433608ENST00000396463TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000433608ENST00000534050TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000393382ENST00000431639TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-5UTRENST00000393382ENST00000316024TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000393382ENST00000457584TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000393382ENST00000396463TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000393382ENST00000534050TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000470462ENST00000431639TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-5UTRENST00000470462ENST00000316024TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000470462ENST00000457584TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000470462ENST00000396463TTLL6chr17

46893201

-WRAP53chr17

7590695

+
intron-intronENST00000470462ENST00000534050TTLL6chr17

46893201

-WRAP53chr17

7590695

+

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FusionProtFeatures for TTLL6_WRAP53


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTLL6

Q8N841

WRAP53

Q9BUR4

Essential component of the telomerase holoenzymecomplex, a ribonucleoprotein complex essential for the replicationof chromosome termini that elongates telomeres in most eukaryotes.In the telomerase holoenzyme complex, it controls telomeraselocalization to Cajal body. Required for delivery of TERC totelomeres during S phase and for telomerase activity. Binds smallCajal body RNAs (scaRNAs). The mRNA encoding this protein plays acritical role in the regulation of p53 expression at the post-transcriptional level; it is involved both in maintaining basalp53 mRNA levels and in p53 induction upon DNA damage.{ECO:0000269|PubMed:19179534, ECO:0000269|PubMed:19250907}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTLL6_WRAP53


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTLL6_WRAP53


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTLL6APP, MYH9, TBC1D16WRAP53PRPF4, PTGES3, XPC, WAPAL, SNRPC, USP11, TNPO1, RBBP7, GAR1, FAM43A, MDC1, RNF8, H2AFX, HNRNPU, ZFHX3, CCT6A, DKC1, MYBPH, NDUFV3, TCP1, CCT3, STK24, CCT7, CCT4, CCT2, CCT8, CCT5, PRPF38B, PTPN1, RAP1B, RXRB, POLG2, CNTROB, MRPL14, KIAA1683, LYPD4, CRYL1, ARHGAP25, FAM46A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTLL6_WRAP53


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTLL6_WRAP53


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneWRAP53C3151442DYSKERATOSIS CONGENITA, AUTOSOMAL RECESSIVE, 31UNIPROT