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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40029

FusionGeneSummary for TTLL4_DHRSX

check button Fusion gene summary
Fusion gene informationFusion gene name: TTLL4_DHRSX
Fusion gene ID: 40029
HgeneTgene
Gene symbol

TTLL4

DHRSX

Gene ID

9654

207063

Gene nametubulin tyrosine ligase like 4dehydrogenase/reductase X-linked
Synonyms-CXorf11|DHRS5X|DHRS5Y|DHRSXY|DHRSY|SDR46C1|SDR7C6
Cytomap

2q35

Xp22.33 and Yp11.2

Type of geneprotein-codingprotein-coding
Descriptiontubulin polyglutamylase TTLL4tubulin tyrosine ligase-like family, member 4tubulin--tyrosine ligase-like protein 4dehydrogenase/reductase SDR family member on chromosome Xdehydrogenase/reductase (SDR family) X chromosomedehydrogenase/reductase (SDR family) X-linkeddehydrogenase/reductase (SDR family) Y-linkedshort chain dehydrogenase/reductase family 46C member 1
Modification date2018051920180523
UniProtAcc

Q14679

Q8N5I4

Ensembl transtripts involved in fusion geneENST00000457313, ENST00000392102, 
ENST00000442769, ENST00000258398, 
ENST00000334651, ENST00000464935, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: TTLL4 [Title/Abstract] AND DHRSX [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-X6-A7WC-01ATTLL4chr2

219575760

+DHRSXchrY

2159644

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000457313ENST00000334651TTLL4chr2

219575760

+DHRSXchrY

2159644

-
intron-intronENST00000457313ENST00000464935TTLL4chr2

219575760

+DHRSXchrY

2159644

-
5UTR-3CDSENST00000392102ENST00000334651TTLL4chr2

219575760

+DHRSXchrY

2159644

-
5UTR-intronENST00000392102ENST00000464935TTLL4chr2

219575760

+DHRSXchrY

2159644

-
5UTR-3CDSENST00000442769ENST00000334651TTLL4chr2

219575760

+DHRSXchrY

2159644

-
5UTR-intronENST00000442769ENST00000464935TTLL4chr2

219575760

+DHRSXchrY

2159644

-
intron-3CDSENST00000258398ENST00000334651TTLL4chr2

219575760

+DHRSXchrY

2159644

-
intron-intronENST00000258398ENST00000464935TTLL4chr2

219575760

+DHRSXchrY

2159644

-

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FusionProtFeatures for TTLL4_DHRSX


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTLL4

Q14679

DHRSX

Q8N5I4

Glutamylase which preferentially modifies beta-tubulinand non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS.Involved in the side-chain initiation step of thepolyglutamylation reaction rather than in the elongation step.Involved in formation of short side-chains. Mediates initiation ofpolyglutamylation of nucleosome assembly proteins NAP1L1 andNAP1L4. Also acts as a monoglutamylase: generatesmonoglutamylation of CGAS, leading to impair thenucleotidyltransferase activity of CGAS.{ECO:0000250|UniProtKB:Q80UG8}. Involved in the positive regulation of starvation-induced autophagy (PubMed:25076851).{ECO:0000269|PubMed:25076851}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTLL4_DHRSX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTLL4_DHRSX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTLL4NXF1, LZTS2, PCM1, XPO1, MAPK8IP1, VTN, AGTPBP1DHRSXAPP, ATXN1, GCNT3, ZBED1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTLL4_DHRSX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTLL4_DHRSX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource