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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 40005

FusionGeneSummary for TTC7B_NT5E

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC7B_NT5E
Fusion gene ID: 40005
HgeneTgene
Gene symbol

TTC7B

NT5E

Gene ID

145567

4907

Gene nametetratricopeptide repeat domain 7B5'-nucleotidase ecto
SynonymsTTC7L1|c14_5685CALJA|CD73|E5NT|NT|NT5|NTE|eN|eNT
Cytomap

14q32.11

6q14.3

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 7BTPR repeat protein 7-like-1TPR repeat protein 7Btetratricopeptide repeat domain 7 like 1tetratricopeptide repeat protein 7-like-15'-nucleotidase5'-NTPurine 5-Prime-Nucleotidaseecto-5'-nucleotidase
Modification date2018052320180520
UniProtAcc

Q86TV6

P21589

Ensembl transtripts involved in fusion geneENST00000357056, ENST00000328459, 
ENST00000554654, 
ENST00000369646, 
ENST00000257770, ENST00000369651, 
Fusion gene scores* DoF score9 X 9 X 7=5672 X 2 X 2=8
# samples 102
** MAII scorelog2(10/567*10)=-2.5033487351675
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: TTC7B [Title/Abstract] AND NT5E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTC7B

GO:0046854

phosphatidylinositol phosphorylation

23229899|26571211

HgeneTTC7B

GO:0072659

protein localization to plasma membrane

23229899|26571211

TgeneNT5E

GO:0007159

leukocyte cell-cell adhesion

7595232


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BU622781TTC7Bchr14

91233316

-NT5Echr6

86203971

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000357056ENST00000369646TTC7Bchr14

91233316

-NT5Echr6

86203971

-
intron-3UTRENST00000357056ENST00000257770TTC7Bchr14

91233316

-NT5Echr6

86203971

-
intron-3UTRENST00000357056ENST00000369651TTC7Bchr14

91233316

-NT5Echr6

86203971

-
intron-intronENST00000328459ENST00000369646TTC7Bchr14

91233316

-NT5Echr6

86203971

-
intron-3UTRENST00000328459ENST00000257770TTC7Bchr14

91233316

-NT5Echr6

86203971

-
intron-3UTRENST00000328459ENST00000369651TTC7Bchr14

91233316

-NT5Echr6

86203971

-
intron-intronENST00000554654ENST00000369646TTC7Bchr14

91233316

-NT5Echr6

86203971

-
intron-3UTRENST00000554654ENST00000257770TTC7Bchr14

91233316

-NT5Echr6

86203971

-
intron-3UTRENST00000554654ENST00000369651TTC7Bchr14

91233316

-NT5Echr6

86203971

-

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FusionProtFeatures for TTC7B_NT5E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTC7B

Q86TV6

NT5E

P21589

Component of a complex required to localizephosphatidylinositol 4-kinase (PI4K) to the plasma membrane. Thecomplex acts as a regulator of phosphatidylinositol 4-phosphate(PtdIns(4)P) synthesis. In the complex, plays a central role inbridging PI4KA to EFR3B and FAM126A, via direct interactions(PubMed:26571211). {ECO:0000269|PubMed:23229899,ECO:0000269|PubMed:26571211}. Hydrolyzes extracellular nucleotides into membranepermeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidaseactivities. {ECO:0000269|PubMed:21933152}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTC7B_NT5E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTC7B_NT5E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTC7B_NT5E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNT5EP21589DB00806Pentoxifylline5'-nucleotidasesmall moleculeapproved|investigational

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RelatedDiseases for TTC7B_NT5E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNT5EC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNT5EC0038356Stomach Neoplasms1CTD_human
TgeneNT5EC1859372Calcification of Joints and Arteries1CTD_human;ORPHANET;UNIPROT