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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39996

FusionGeneSummary for TTC6_FAM131C

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC6_FAM131C
Fusion gene ID: 39996
HgeneTgene
Gene symbol

TTC6

FAM131C

Gene ID

319089

348487

Gene nametetratricopeptide repeat domain 6family with sequence similarity 131 member C
SynonymsC14orf25|NCRNA00291C1orf117
Cytomap

14q21.1

1p36.13

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 6TPR repeat protein 6protein FAM131C
Modification date2018033120180519
UniProtAcc

Q86TZ1

Q96AQ9

Ensembl transtripts involved in fusion geneENST00000553443, ENST00000476979, 
ENST00000267368, ENST00000382320, 
ENST00000554555, 		ENST00000375662, 
ENST00000494078, 
Fusion gene scores* DoF score7 X 4 X 2=561 X 1 X 1=1
# samples 61
** MAII scorelog2(6/56*10)=0.0995356735509144
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: TTC6 [Title/Abstract] AND FAM131C [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A04W-01ATTC6chr14

38208360

+FAM131Cchr1

16389029

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000553443ENST00000375662TTC6chr14

38208360

+FAM131Cchr1

16389029

-
5CDS-5UTRENST00000553443ENST00000494078TTC6chr14

38208360

+FAM131Cchr1

16389029

-
intron-3CDSENST00000476979ENST00000375662TTC6chr14

38208360

+FAM131Cchr1

16389029

-
intron-5UTRENST00000476979ENST00000494078TTC6chr14

38208360

+FAM131Cchr1

16389029

-
intron-3CDSENST00000267368ENST00000375662TTC6chr14

38208360

+FAM131Cchr1

16389029

-
intron-5UTRENST00000267368ENST00000494078TTC6chr14

38208360

+FAM131Cchr1

16389029

-
intron-3CDSENST00000382320ENST00000375662TTC6chr14

38208360

+FAM131Cchr1

16389029

-
intron-5UTRENST00000382320ENST00000494078TTC6chr14

38208360

+FAM131Cchr1

16389029

-
intron-3CDSENST00000554555ENST00000375662TTC6chr14

38208360

+FAM131Cchr1

16389029

-
intron-5UTRENST00000554555ENST00000494078TTC6chr14

38208360

+FAM131Cchr1

16389029

-

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FusionProtFeatures for TTC6_FAM131C


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTC6

Q86TZ1

FAM131C

Q96AQ9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTC6_FAM131C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTC6_FAM131C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTC6FAM131CDNAJA3, EWSR1, GRN, VSNL1, MAD1L1, MYC, APP, NDN, SFI1, HPCAL4, LMO3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTC6_FAM131C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTC6_FAM131C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource