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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3996

FusionGeneSummary for BCCIP_BCCIP

check button Fusion gene summary
Fusion gene informationFusion gene name: BCCIP_BCCIP
Fusion gene ID: 3996
HgeneTgene
Gene symbol

BCCIP

BCCIP

Gene ID

56647

56647

Gene nameBRCA2 and CDKN1A interacting proteinBRCA2 and CDKN1A interacting protein
SynonymsTOK-1|TOK1TOK-1|TOK1
Cytomap

10q26.2

10q26.2

Type of geneprotein-codingprotein-coding
DescriptionBRCA2 and CDKN1A-interacting proteinBCCIPalphaBCCIPbetaBRCA2 and Cip1/p21 interacting proteinTOK-1alphaTOK-1betacdk inhibitor p21 binding proteinp21- and CDK-associated protein 1protein TOK-1BRCA2 and CDKN1A-interacting proteinBCCIPalphaBCCIPbetaBRCA2 and Cip1/p21 interacting proteinTOK-1alphaTOK-1betacdk inhibitor p21 binding proteinp21- and CDK-associated protein 1protein TOK-1
Modification date2018052320180523
UniProtAcc

Q9P287

Q9P287

Ensembl transtripts involved in fusion geneENST00000368759, ENST00000278100, 
ENST00000429863, ENST00000299130, 
ENST00000478798, 		ENST00000368759, 
ENST00000278100, ENST00000429863, 
ENST00000299130, ENST00000478798, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 1=4
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/4*10)=2.32192809488736
Context

PubMed: BCCIP [Title/Abstract] AND BCCIP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBCCIP

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

10878006

HgeneBCCIP

GO:0061101

neuroendocrine cell differentiation

18440304

TgeneBCCIP

GO:0000079

regulation of cyclin-dependent protein serine/threonine kinase activity

10878006

TgeneBCCIP

GO:0061101

neuroendocrine cell differentiation

18440304


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA226439BCCIPchr10

127520148

+BCCIPchr10

127520037

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000368759ENST00000368759BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000368759ENST00000278100BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000368759ENST00000429863BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000368759ENST00000299130BCCIPchr10

127520148

+BCCIPchr10

127520037

-
5CDS-3UTRENST00000368759ENST00000478798BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000278100ENST00000368759BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000278100ENST00000278100BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000278100ENST00000429863BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000278100ENST00000299130BCCIPchr10

127520148

+BCCIPchr10

127520037

-
5CDS-3UTRENST00000278100ENST00000478798BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000429863ENST00000368759BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000429863ENST00000278100BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000429863ENST00000429863BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000429863ENST00000299130BCCIPchr10

127520148

+BCCIPchr10

127520037

-
5CDS-3UTRENST00000429863ENST00000478798BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000299130ENST00000368759BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000299130ENST00000278100BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000299130ENST00000429863BCCIPchr10

127520148

+BCCIPchr10

127520037

-
Frame-shiftENST00000299130ENST00000299130BCCIPchr10

127520148

+BCCIPchr10

127520037

-
5CDS-3UTRENST00000299130ENST00000478798BCCIPchr10

127520148

+BCCIPchr10

127520037

-
intron-3CDSENST00000478798ENST00000368759BCCIPchr10

127520148

+BCCIPchr10

127520037

-
intron-3CDSENST00000478798ENST00000278100BCCIPchr10

127520148

+BCCIPchr10

127520037

-
intron-3CDSENST00000478798ENST00000429863BCCIPchr10

127520148

+BCCIPchr10

127520037

-
intron-3CDSENST00000478798ENST00000299130BCCIPchr10

127520148

+BCCIPchr10

127520037

-
intron-3UTRENST00000478798ENST00000478798BCCIPchr10

127520148

+BCCIPchr10

127520037

-

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FusionProtFeatures for BCCIP_BCCIP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCCIP

Q9P287

BCCIP

Q9P287

During interphase, required for microtubule organizingand anchoring activities. During mitosis, required for theorganization and stabilization of the spindle pole(PubMed:28394342). Isoform 2/alpha is particularly important forthe regulation of microtubule anchoring, microtubule stability,spindle architecture and spindle orientation, compared to isoform1/beta (PubMed:28394342). May promote cell cycle arrest byenhancing the inhibition of CDK2 activity by CDKN1A. May berequired for repair of DNA damage by homologous recombination inconjunction with BRCA2. May not be involved in non-homologous endjoining (NHEJ). {ECO:0000269|PubMed:10878006,ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944,ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333,ECO:0000269|PubMed:28394342}. During interphase, required for microtubule organizingand anchoring activities. During mitosis, required for theorganization and stabilization of the spindle pole(PubMed:28394342). Isoform 2/alpha is particularly important forthe regulation of microtubule anchoring, microtubule stability,spindle architecture and spindle orientation, compared to isoform1/beta (PubMed:28394342). May promote cell cycle arrest byenhancing the inhibition of CDK2 activity by CDKN1A. May berequired for repair of DNA damage by homologous recombination inconjunction with BRCA2. May not be involved in non-homologous endjoining (NHEJ). {ECO:0000269|PubMed:10878006,ECO:0000269|PubMed:14726710, ECO:0000269|PubMed:15539944,ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:17947333,ECO:0000269|PubMed:28394342}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for BCCIP_BCCIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for BCCIP_BCCIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for BCCIP_BCCIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for BCCIP_BCCIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource