FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39956

FusionGeneSummary for TTC28_FAM19A5

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC28_FAM19A5
Fusion gene ID: 39956
HgeneTgene
Gene symbol

TTC28

FAM19A5

Gene ID

23331

25817

Gene nametetratricopeptide repeat domain 28family with sequence similarity 19 member A5, C-C motif chemokine like
SynonymsTPRBKQLLK5208|TAFA-5|TAFA5|UNQ5208
Cytomap

22q12.1

22q13.32

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 28TPR repeat protein 28TPR repeat-containing big gene cloned at KeioTPR-containing big gene cloned at Keioprotein FAM19A5TAFA protein 5chemokine-like protein TAFA-5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
Modification date2018051920180329
UniProtAcc

Q96AY4

Q7Z5A7

Ensembl transtripts involved in fusion geneENST00000397906, ENST00000490475, 
ENST00000402357, ENST00000358295, 
ENST00000473898, ENST00000406880, 
Fusion gene scores* DoF score15 X 8 X 9=10806 X 3 X 5=90
# samples 156
** MAII scorelog2(15/1080*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TTC28 [Title/Abstract] AND FAM19A5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-HT-A74H-01ATTC28chr22

29025540

-FAM19A5chr22

49042409

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000397906ENST00000402357TTC28chr22

29025540

-FAM19A5chr22

49042409

+
Frame-shiftENST00000397906ENST00000358295TTC28chr22

29025540

-FAM19A5chr22

49042409

+
5CDS-intronENST00000397906ENST00000473898TTC28chr22

29025540

-FAM19A5chr22

49042409

+
5CDS-intronENST00000397906ENST00000406880TTC28chr22

29025540

-FAM19A5chr22

49042409

+
intron-3CDSENST00000490475ENST00000402357TTC28chr22

29025540

-FAM19A5chr22

49042409

+
intron-3CDSENST00000490475ENST00000358295TTC28chr22

29025540

-FAM19A5chr22

49042409

+
intron-intronENST00000490475ENST00000473898TTC28chr22

29025540

-FAM19A5chr22

49042409

+
intron-intronENST00000490475ENST00000406880TTC28chr22

29025540

-FAM19A5chr22

49042409

+

Top

FusionProtFeatures for TTC28_FAM19A5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTC28

Q96AY4

FAM19A5

Q7Z5A7


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TTC28_FAM19A5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TTC28_FAM19A5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTC28BRE, SSPO, UBC, YWHAB, BSG, HLA-B, SDF4, NCK2, PRMT2, NTRK1, TP53, MED4, MED23, CEP120, CEP152, NINL, NIN, SASS6, P4HA2, HTRA4, TSPYL6, CD79A, PCDHGB1, DOCK5, ICAM1FAM19A5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TTC28_FAM19A5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TTC28_FAM19A5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource