|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 39952 |
FusionGeneSummary for TTC28_ASCC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TTC28_ASCC2 | Fusion gene ID: 39952 | Hgene | Tgene | Gene symbol | TTC28 | ASCC2 | Gene ID | 23331 | 84164 |
| Gene name | tetratricopeptide repeat domain 28 | activating signal cointegrator 1 complex subunit 2 | |
| Synonyms | TPRBK | ASC1p100|p100 | |
| Cytomap | 22q12.1 | 22q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tetratricopeptide repeat protein 28TPR repeat protein 28TPR repeat-containing big gene cloned at KeioTPR-containing big gene cloned at Keio | activating signal cointegrator 1 complex subunit 2ASC-1 complex subunit P100trip4 complex subunit p100 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q96AY4 | Q9H1I8 | |
| Ensembl transtripts involved in fusion gene | ENST00000397906, ENST00000490475, | ENST00000307790, ENST00000397771, ENST00000542393, ENST00000478812, | |
| Fusion gene scores | * DoF score | 15 X 8 X 9=1080 | 7 X 7 X 6=294 |
| # samples | 15 | 8 | |
| ** MAII score | log2(15/1080*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/294*10)=-1.877744249949 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TTC28 [Title/Abstract] AND ASCC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ASCC2 | GO:0006355 | regulation of transcription, DNA-templated | 12077347 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-C8-A135-01A | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000397906 | ENST00000307790 | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
| In-frame | ENST00000397906 | ENST00000397771 | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
| In-frame | ENST00000397906 | ENST00000542393 | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
| 5CDS-intron | ENST00000397906 | ENST00000478812 | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
| intron-3CDS | ENST00000490475 | ENST00000307790 | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
| intron-3CDS | ENST00000490475 | ENST00000397771 | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
| intron-3CDS | ENST00000490475 | ENST00000542393 | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
| intron-intron | ENST00000490475 | ENST00000478812 | TTC28 | chr22 | 28692186 | - | ASCC2 | chr22 | 30186537 | - |
Top |
FusionProtFeatures for TTC28_ASCC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TTC28 | ASCC2 |
| Enhances NF-kappa-B, SRF and AP1 transactivation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 126_159 | 311 | 2482 | Repeat | Note=TPR 3 |
| Hgene | TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 196_229 | 311 | 2482 | Repeat | Note=TPR 4 |
| Hgene | TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 234_267 | 311 | 2482 | Repeat | Note=TPR 5 |
| Hgene | TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 274_307 | 311 | 2482 | Repeat | Note=TPR 6 |
| Hgene | TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 58_91 | 311 | 2482 | Repeat | Note=TPR 1 |
| Hgene | TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 93_125 | 311 | 2482 | Repeat | Note=TPR 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 1948_2006 | 311 | 2482 | Compositional bias | Note=Ser-rich |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 2201_2335 | 311 | 2482 | Compositional bias | Note=Ser-rich |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 1037_1070 | 311 | 2482 | Repeat | Note=TPR 25 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 1077_1110 | 311 | 2482 | Repeat | Note=TPR 26 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 1117_1150 | 311 | 2482 | Repeat | Note=TPR 27 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 1169_1202 | 311 | 2482 | Repeat | Note=TPR 28 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 314_347 | 311 | 2482 | Repeat | Note=TPR 7 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 354_387 | 311 | 2482 | Repeat | Note=TPR 8 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 394_427 | 311 | 2482 | Repeat | Note=TPR 9 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 434_467 | 311 | 2482 | Repeat | Note=TPR 10 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 474_507 | 311 | 2482 | Repeat | Note=TPR 11 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 514_547 | 311 | 2482 | Repeat | Note=TPR 12 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 554_587 | 311 | 2482 | Repeat | Note=TPR 13 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 594_627 | 311 | 2482 | Repeat | Note=TPR 14 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 634_667 | 311 | 2482 | Repeat | Note=TPR 15 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 674_707 | 311 | 2482 | Repeat | Note=TPR 16 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 714_747 | 311 | 2482 | Repeat | Note=TPR 17 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 754_787 | 311 | 2482 | Repeat | Note=TPR 18 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 794_827 | 311 | 2482 | Repeat | Note=TPR 19 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 834_867 | 311 | 2482 | Repeat | Note=TPR 20 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 877_910 | 311 | 2482 | Repeat | Note=TPR 21 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 917_950 | 311 | 2482 | Repeat | Note=TPR 22 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 957_990 | 311 | 2482 | Repeat | Note=TPR 23 |
| Hgene | >TTC28 | chr22:28692186 | chr22:30186537 | ENST00000397906 | - | 5 | 23 | 997_1030 | 311 | 2482 | Repeat | Note=TPR 24 |
| Tgene | ASCC2 | chr22:28692186 | chr22:30186537 | ENST00000307790 | - | 17 | 20 | 467_510 | 674 | 758 | Domain | CUE |
| Tgene | ASCC2 | chr22:28692186 | chr22:30186537 | ENST00000397771 | - | 18 | 21 | 467_510 | 674 | 758 | Domain | CUE |
| Tgene | ASCC2 | chr22:28692186 | chr22:30186537 | ENST00000542393 | - | 16 | 19 | 467_510 | 598 | 682 | Domain | CUE |
Top |
FusionGeneSequence for TTC28_ASCC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000307790_chr22_30186537_-_395aa MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQ NCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE PTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQ TGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQSRET >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000397771_chr22_30186537_-_395aa MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQ NCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE PTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQ TGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQSRET >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000542393_chr22_30186537_-_395aa MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVEKVRQSNQACHDGDFHTAIVLYNEALAVDPQ NCILYSNRSAAYMKIQQYDKALDDAIKARLLNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE PTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSALSSAYWSLGNTEKSTGYMQQDLDVAKTLGDQ TGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREPDHFVQDPAVLREKAEARRMAFLAKKGYRHDSSTAVAGSPRGHGQSRET |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000307790_chr22_30186537_-_1185nt ATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCAAGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCG GCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTATTGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAG AAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGATTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAG AACTGCATCTTATACAGCAATAGATCTGCAGCCTACATGAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTT CTCAATCCCAAGTGGCCAAAGGCATACTTCCGACAGGGTGTTGCCCTCCAGTACCTTGGACGTCATGCCGATGCCCTGGCAGCCTTTGCA TCTGGACTGGCTCAAGACCCCAAGAGTCTCCAGCTTCTGGTGGGGATGGTGGAAGCCGCCATGAAATCTCCCATGAGAGACTCCCTCGAG CCCACTTATCAGCAGCTTCAGAAAATGAAACTGGACAAGAGTCCCTTTGTGGTCGTGTCTGTGGTTGGGCAGGAACTCCTGACAGCTGGC CATCATGGGGCCTCTGTGGTTGTCTTAGAAGCCGCACTGAAGATTGGCACCTGCAGCCTCAAACTGAGAGGTTCTGTTTTCTCTGCCCTG AGCAGTGCTTACTGGTCTCTTGGAAATACAGAGAAGAGCACCGGATATATGCAGCAGGACTTGGATGTAGCCAAGACCTTAGGTGACCAG ACAGGAGAATGCCGAGCTCATGGGAATCTGGGCTCTGCATTCTTCTCCAAAGGAAATTACCGGGAGGCTCTCACTAACCACAGGCATCAG TTGGTACTCGCCATGAAACTCAAAGATCGAGAGCCCGACCATTTTGTTCAGGACCCTGCAGTGCTGAGAGAGAAGGCAGAAGCCAGGCGC ATGGCCTTTCTCGCCAAGAAAGGGTACCGGCATGACAGCTCAACAGCAGTGGCCGGCAGCCCCCGAGGCCATGGGCAGAGCCGCGAGACA ACCCAGGAACGCAGGAAGAAGGAAGCCAACAAGGCGACAAGAGCCAACCACAACCGGAGAACCATGGCCGACCGCAAGAGGAGCAAAGGC >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000397771_chr22_30186537_-_1185nt ATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCAAGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCG GCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTATTGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAG AAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGATTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAG AACTGCATCTTATACAGCAATAGATCTGCAGCCTACATGAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTT CTCAATCCCAAGTGGCCAAAGGCATACTTCCGACAGGGTGTTGCCCTCCAGTACCTTGGACGTCATGCCGATGCCCTGGCAGCCTTTGCA TCTGGACTGGCTCAAGACCCCAAGAGTCTCCAGCTTCTGGTGGGGATGGTGGAAGCCGCCATGAAATCTCCCATGAGAGACTCCCTCGAG CCCACTTATCAGCAGCTTCAGAAAATGAAACTGGACAAGAGTCCCTTTGTGGTCGTGTCTGTGGTTGGGCAGGAACTCCTGACAGCTGGC CATCATGGGGCCTCTGTGGTTGTCTTAGAAGCCGCACTGAAGATTGGCACCTGCAGCCTCAAACTGAGAGGTTCTGTTTTCTCTGCCCTG AGCAGTGCTTACTGGTCTCTTGGAAATACAGAGAAGAGCACCGGATATATGCAGCAGGACTTGGATGTAGCCAAGACCTTAGGTGACCAG ACAGGAGAATGCCGAGCTCATGGGAATCTGGGCTCTGCATTCTTCTCCAAAGGAAATTACCGGGAGGCTCTCACTAACCACAGGCATCAG TTGGTACTCGCCATGAAACTCAAAGATCGAGAGCCCGACCATTTTGTTCAGGACCCTGCAGTGCTGAGAGAGAAGGCAGAAGCCAGGCGC ATGGCCTTTCTCGCCAAGAAAGGGTACCGGCATGACAGCTCAACAGCAGTGGCCGGCAGCCCCCGAGGCCATGGGCAGAGCCGCGAGACA ACCCAGGAACGCAGGAAGAAGGAAGCCAACAAGGCGACAAGAGCCAACCACAACCGGAGAACCATGGCCGACCGCAAGAGGAGCAAAGGC >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000542393_chr22_30186537_-_1185nt ATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCAAGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCG GCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTATTGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAG AAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGATTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAG AACTGCATCTTATACAGCAATAGATCTGCAGCCTACATGAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTT CTCAATCCCAAGTGGCCAAAGGCATACTTCCGACAGGGTGTTGCCCTCCAGTACCTTGGACGTCATGCCGATGCCCTGGCAGCCTTTGCA TCTGGACTGGCTCAAGACCCCAAGAGTCTCCAGCTTCTGGTGGGGATGGTGGAAGCCGCCATGAAATCTCCCATGAGAGACTCCCTCGAG CCCACTTATCAGCAGCTTCAGAAAATGAAACTGGACAAGAGTCCCTTTGTGGTCGTGTCTGTGGTTGGGCAGGAACTCCTGACAGCTGGC CATCATGGGGCCTCTGTGGTTGTCTTAGAAGCCGCACTGAAGATTGGCACCTGCAGCCTCAAACTGAGAGGTTCTGTTTTCTCTGCCCTG AGCAGTGCTTACTGGTCTCTTGGAAATACAGAGAAGAGCACCGGATATATGCAGCAGGACTTGGATGTAGCCAAGACCTTAGGTGACCAG ACAGGAGAATGCCGAGCTCATGGGAATCTGGGCTCTGCATTCTTCTCCAAAGGAAATTACCGGGAGGCTCTCACTAACCACAGGCATCAG TTGGTACTCGCCATGAAACTCAAAGATCGAGAGCCCGACCATTTTGTTCAGGACCCTGCAGTGCTGAGAGAGAAGGCAGAAGCCAGGCGC ATGGCCTTTCTCGCCAAGAAAGGGTACCGGCATGACAGCTCAACAGCAGTGGCCGGCAGCCCCCGAGGCCATGGGCAGAGCCGCGAGACA ACCCAGGAACGCAGGAAGAAGGAAGCCAACAAGGCGACAAGAGCCAACCACAACCGGAGAACCATGGCCGACCGCAAGAGGAGCAAAGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000307790_chr22_30186537_-_1732nt GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGGCATACTTCCGACAGGG TGTTGCCCTCCAGTACCTTGGACGTCATGCCGATGCCCTGGCAGCCTTTGCATCTGGACTGGCTCAAGACCCCAAGAGTCTCCAGCTTCT GGTGGGGATGGTGGAAGCCGCCATGAAATCTCCCATGAGAGACTCCCTCGAGCCCACTTATCAGCAGCTTCAGAAAATGAAACTGGACAA GAGTCCCTTTGTGGTCGTGTCTGTGGTTGGGCAGGAACTCCTGACAGCTGGCCATCATGGGGCCTCTGTGGTTGTCTTAGAAGCCGCACT GAAGATTGGCACCTGCAGCCTCAAACTGAGAGGTTCTGTTTTCTCTGCCCTGAGCAGTGCTTACTGGTCTCTTGGAAATACAGAGAAGAG CACCGGATATATGCAGCAGGACTTGGATGTAGCCAAGACCTTAGGTGACCAGACAGGAGAATGCCGAGCTCATGGGAATCTGGGCTCTGC ATTCTTCTCCAAAGGAAATTACCGGGAGGCTCTCACTAACCACAGGCATCAGTTGGTACTCGCCATGAAACTCAAAGATCGAGAGCCCGA CCATTTTGTTCAGGACCCTGCAGTGCTGAGAGAGAAGGCAGAAGCCAGGCGCATGGCCTTTCTCGCCAAGAAAGGGTACCGGCATGACAG CTCAACAGCAGTGGCCGGCAGCCCCCGAGGCCATGGGCAGAGCCGCGAGACAACCCAGGAACGCAGGAAGAAGGAAGCCAACAAGGCGAC AAGAGCCAACCACAACCGGAGAACCATGGCCGACCGCAAGAGGAGCAAAGGCATGATCCCATCCTGAGACCTGGTGCAGGGCCAGTGGGG AGGCAGCGGCACCAGACTCACCAGGCCGTGCTCCCATCGCCTGGGGCCTCCTCACTAGGGGCCCCAAGTTCAACTCAACCCCTCAACAGC CTCAGCTTTGCAGCCCCTGAGAAGGCCGCCTCTCATCTACCAGCCAGCCATGAGCGCCTTCCTGCAGAACACACAGTGCCTTATGCCACA GCCGAAGAATCCGTGGGGCCGGCAAGCAGGCACCTTCCCCCAGCTGCGCTAGCGGGAAAGAGATGGGGATGGAGTCCCAAGGCAAGCGCC CCAAACCTCGGGCCACAAGACACCACTTCCCCTTTACCCTGGACAGCAGGAAACCTGTATATTCAAAAACACAAAAAGTCCTGCTAATAA >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000397771_chr22_30186537_-_1698nt GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGGCATACTTCCGACAGGG TGTTGCCCTCCAGTACCTTGGACGTCATGCCGATGCCCTGGCAGCCTTTGCATCTGGACTGGCTCAAGACCCCAAGAGTCTCCAGCTTCT GGTGGGGATGGTGGAAGCCGCCATGAAATCTCCCATGAGAGACTCCCTCGAGCCCACTTATCAGCAGCTTCAGAAAATGAAACTGGACAA GAGTCCCTTTGTGGTCGTGTCTGTGGTTGGGCAGGAACTCCTGACAGCTGGCCATCATGGGGCCTCTGTGGTTGTCTTAGAAGCCGCACT GAAGATTGGCACCTGCAGCCTCAAACTGAGAGGTTCTGTTTTCTCTGCCCTGAGCAGTGCTTACTGGTCTCTTGGAAATACAGAGAAGAG CACCGGATATATGCAGCAGGACTTGGATGTAGCCAAGACCTTAGGTGACCAGACAGGAGAATGCCGAGCTCATGGGAATCTGGGCTCTGC ATTCTTCTCCAAAGGAAATTACCGGGAGGCTCTCACTAACCACAGGCATCAGTTGGTACTCGCCATGAAACTCAAAGATCGAGAGCCCGA CCATTTTGTTCAGGACCCTGCAGTGCTGAGAGAGAAGGCAGAAGCCAGGCGCATGGCCTTTCTCGCCAAGAAAGGGTACCGGCATGACAG CTCAACAGCAGTGGCCGGCAGCCCCCGAGGCCATGGGCAGAGCCGCGAGACAACCCAGGAACGCAGGAAGAAGGAAGCCAACAAGGCGAC AAGAGCCAACCACAACCGGAGAACCATGGCCGACCGCAAGAGGAGCAAAGGCATGATCCCATCCTGAGACCTGGTGCAGGGCCAGTGGGG AGGCAGCGGCACCAGACTCACCAGGCCGTGCTCCCATCGCCTGGGGCCTCCTCACTAGGGGCCCCAAGTTCAACTCAACCCCTCAACAGC CTCAGCTTTGCAGCCCCTGAGAAGGCCGCCTCTCATCTACCAGCCAGCCATGAGCGCCTTCCTGCAGAACACACAGTGCCTTATGCCACA GCCGAAGAATCCGTGGGGCCGGCAAGCAGGCACCTTCCCCCAGCTGCGCTAGCGGGAAAGAGATGGGGATGGAGTCCCAAGGCAAGCGCC >In-frame_TTC28_ENST00000397906_chr22_28692186_-_ASCC2_ENST00000542393_chr22_30186537_-_1458nt GGGGGCGCGCGCGCGGTTTGGGGGCAGTGAGGGGCGCCGCGGCGGCGCGCAGCACGGCGGGAACATGGCGCGCGGAACCGGCGCGCGCGC CTAGCTGGCGGGACCGTTAGCTCGAGGCGGACGCGGCCCGGGCCCCGTGGGGATGGAGCAGTCGCCGCCGCCGGCGCCCGAGCCGACCCA AGGGCCGACCCCCGCAAGGAGCCGAAGGCGGCGGGAGCCAGAGTCGCCGCCGGCGTCGGCGCCGATTCCTCTCTTTGGTGCTGACACTAT TGGCCAGAGAAGTCCTGATGGACCGGTACTGAGCAAAGCTGAATTTGTTGAGAAAGTTCGTCAGAGTAATCAGGCCTGTCATGATGGAGA TTTCCACACAGCTATTGTTCTGTATAATGAAGCCCTGGCTGTTGACCCTCAGAACTGCATCTTATACAGCAATAGATCTGCAGCCTACAT GAAAATCCAGCAGTATGACAAGGCACTGGATGATGCAATCAAAGCTCGACTTCTCAATCCCAAGTGGCCAAAGGCATACTTCCGACAGGG TGTTGCCCTCCAGTACCTTGGACGTCATGCCGATGCCCTGGCAGCCTTTGCATCTGGACTGGCTCAAGACCCCAAGAGTCTCCAGCTTCT GGTGGGGATGGTGGAAGCCGCCATGAAATCTCCCATGAGAGACTCCCTCGAGCCCACTTATCAGCAGCTTCAGAAAATGAAACTGGACAA GAGTCCCTTTGTGGTCGTGTCTGTGGTTGGGCAGGAACTCCTGACAGCTGGCCATCATGGGGCCTCTGTGGTTGTCTTAGAAGCCGCACT GAAGATTGGCACCTGCAGCCTCAAACTGAGAGGTTCTGTTTTCTCTGCCCTGAGCAGTGCTTACTGGTCTCTTGGAAATACAGAGAAGAG CACCGGATATATGCAGCAGGACTTGGATGTAGCCAAGACCTTAGGTGACCAGACAGGAGAATGCCGAGCTCATGGGAATCTGGGCTCTGC ATTCTTCTCCAAAGGAAATTACCGGGAGGCTCTCACTAACCACAGGCATCAGTTGGTACTCGCCATGAAACTCAAAGATCGAGAGCCCGA CCATTTTGTTCAGGACCCTGCAGTGCTGAGAGAGAAGGCAGAAGCCAGGCGCATGGCCTTTCTCGCCAAGAAAGGGTACCGGCATGACAG CTCAACAGCAGTGGCCGGCAGCCCCCGAGGCCATGGGCAGAGCCGCGAGACAACCCAGGAACGCAGGAAGAAGGAAGCCAACAAGGCGAC AAGAGCCAACCACAACCGGAGAACCATGGCCGACCGCAAGAGGAGCAAAGGCATGATCCCATCCTGAGACCTGGTGCAGGGCCAGTGGGG AGGCAGCGGCACCAGACTCACCAGGCCGTGCTCCCATCGCCTGGGGCCTCCTCACTAGGGGCCCCAAGTTCAACTCAACCCCTCAACAGC |
Top |
FusionGenePPI for TTC28_ASCC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TTC28 | BRE, SSPO, UBC, YWHAB, BSG, HLA-B, SDF4, NCK2, PRMT2, NTRK1, TP53, MED4, MED23, CEP120, CEP152, NINL, NIN, SASS6, P4HA2, HTRA4, TSPYL6, CD79A, PCDHGB1, DOCK5, ICAM1 | ASCC2 | CUTC, CKAP4, DEAF1, ELAC2, FAF1, GFER, IGSF9, LPL, GNL3, PIK3CD, URM1, RADIL, GTF3C1, FUNDC2, IMMT, MYH9, PIN4, PJA1, POLDIP2, SNRPB, TBC1D17, KDM1A, ASS1, FBP1, POLA2, OLA1, MED31, RPA1, EEF1D, RPLP1, SNW1, PCBD2, RNF11, GADD45A, MAP3K1, ALKBH3, ASCC1, RPS19, ASCC3, GPC4, TRIP4, NTRK1, CC2D2A, CEP128, HDAC1, VCL, NIPSNAP1, EMC2, PAPD5, ENTHD2, SPC24, BAG6, SMURF1, CSRP1, UBC |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for TTC28_ASCC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TTC28_ASCC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|