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Fusion gene ID: 39946 |
FusionGeneSummary for TTC27_BIRC6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TTC27_BIRC6 | Fusion gene ID: 39946 | Hgene | Tgene | Gene symbol | TTC27 | BIRC6 | Gene ID | 55622 | 57448 |
| Gene name | tetratricopeptide repeat domain 27 | baculoviral IAP repeat containing 6 | |
| Synonyms | - | APOLLON|BRUCE | |
| Cytomap | 2p22.3 | 2p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tetratricopeptide repeat protein 27TPR repeat protein 27 | baculoviral IAP repeat-containing protein 6BIR repeat-containing ubiquitin-conjugating enzymeRING-type E3 ubiquitin transferase BIRC6ubiquitin-conjugating BIR-domain enzyme apollon | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q6P3X3 | Q9NR09 | |
| Ensembl transtripts involved in fusion gene | ENST00000317907, | ENST00000421745, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 17 X 11 X 13=2431 |
| # samples | 4 | 23 | |
| ** MAII score | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/2431*10)=-3.40184412708435 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TTC27 [Title/Abstract] AND BIRC6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-94-8491-01A | TTC27 | chr2 | 32961883 | + | BIRC6 | chr2 | 32828073 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000317907 | ENST00000421745 | TTC27 | chr2 | 32961883 | + | BIRC6 | chr2 | 32828073 | + |
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FusionProtFeatures for TTC27_BIRC6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TTC27 | BIRC6 |
| Anti-apoptotic protein which can regulate cell death bycontrolling caspases and by acting as an E3 ubiquitin-proteinligase. Has an unusual ubiquitin conjugation system in that itcould combine in a single polypeptide, ubiquitin conjugating (E2)with ubiquitin ligase (E3) activity, forming a chimeric E2/E3ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Actsas an inhibitor of CASP3, CASP7 and CASP9. Important regulator forthe final stages of cytokinesis. Crucial for normal vesicletargeting to the site of abscission, but also for the integrity ofthe midbody and the midbody ring, and its striking ubiquitinmodification. {ECO:0000269|PubMed:14765125,ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | TTC27 | chr2:32961883 | chr2:32828073 | ENST00000317907 | + | 12 | 20 | 453_486 | 484 | 844 | Repeat | Note=TPR 1 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >TTC27 | chr2:32961883 | chr2:32828073 | ENST00000317907 | + | 12 | 20 | 492_525 | 484 | 844 | Repeat | Note=TPR 2 |
| Hgene | >TTC27 | chr2:32961883 | chr2:32828073 | ENST00000317907 | + | 12 | 20 | 527_560 | 484 | 844 | Repeat | Note=TPR 3 |
| Hgene | >TTC27 | chr2:32961883 | chr2:32828073 | ENST00000317907 | + | 12 | 20 | 561_594 | 484 | 844 | Repeat | Note=TPR 4 |
| Hgene | >TTC27 | chr2:32961883 | chr2:32828073 | ENST00000317907 | + | 12 | 20 | 596_628 | 484 | 844 | Repeat | Note=TPR 5 |
| Hgene | >TTC27 | chr2:32961883 | chr2:32828073 | ENST00000317907 | + | 12 | 20 | 629_662 | 484 | 844 | Repeat | Note=TPR 6 |
| Tgene | BIRC6 | chr2:32961883 | chr2:32828073 | ENST00000421745 | + | 69 | 74 | 1660_1668 | 4664 | 4858 | Compositional bias | Note=Poly-Ala |
| Tgene | BIRC6 | chr2:32961883 | chr2:32828073 | ENST00000421745 | + | 69 | 74 | 30_36 | 4664 | 4858 | Compositional bias | Note=Poly-Ala |
| Tgene | BIRC6 | chr2:32961883 | chr2:32828073 | ENST00000421745 | + | 69 | 74 | 4576_4704 | 4664 | 4858 | Region | Note=Ubiquitin-conjugating |
| Tgene | BIRC6 | chr2:32961883 | chr2:32828073 | ENST00000421745 | + | 69 | 74 | 284_358 | 4664 | 4858 | Repeat | Note=BIR |
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FusionGeneSequence for TTC27_BIRC6 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TTC27_ENST00000317907_chr2_32961883_+_BIRC6_ENST00000421745_chr2_32828073_+_678aa MWTPELAILRGFPTEAERQQWKQEGVVGSESGSFLQLLLEGNYEAIFLNSMTQNIFNSTTTAEEKIDSYLEKQVVTFLDYSTDLDTTERQ QLIFLLGVSSLQLFVQSNWTGPPVDLHPQDFLSSVLFQQFSEVKGLDAFVLSLLTLDGESIYSLTSKPILLLLARIILVNVRHKLTAIQS LPWWTLRCVNIHQHLLEERSPLLFTLAENCIDQVMKLQNLFVDDSGRYLAIQFHLECAYVFLYYYEYRKAKDQLDIAKDISQLQIDLTGA LGKRTRFQENYVAQLILDVRREGDVLSNCEFTPAPTPQEHLTKNLELNDDTILNDIKLADCEQFQMPDLCAEEIAIILGICTNFQKNNPV HTLTEVELLAFTSCLLSQPKFWAIQTSALILRTKLEKGSTRRVERAMRQTQALADQFEDKTTSVLERLKIFYCCQVPPHWAIQRQLASLL FELGCTSSALQIFEKLEMWEDVVICYERAGQHGKVCLSILNTWHGRPEEKWNPQTSSFLQVLVSVQSLILVAEPYFNEPGYERSRGTPSG TQSSREYDGNIRQATVKWAMLEQIRNPSPCFKEVIHKHFYLKRVEIMAQCEEWIADIQQYSSDKRVGRTMSHHAAALKRHTAQLREELLK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TTC27_ENST00000317907_chr2_32961883_+_BIRC6_ENST00000421745_chr2_32828073_+_2034nt ATGTGGACCCCGGAGCTGGCAATTCTGAGGGGATTCCCCACTGAGGCTGAGCGGCAGCAATGGAAACAGGAGGGGGTCGTCGGTTCAGAG AGTGGATCTTTCCTACAATTGCTACTGGAAGGGAACTATGAAGCCATATTCTTAAATTCAATGACTCAAAATATTTTTAATTCAACAACA ACCGCTGAAGAAAAGATTGATAGCTACCTGGAGAAGCAGGTAGTAACATTCCTGGATTACTCAACAGATTTGGACACAACGGAAAGACAA CAGTTGATATTTCTACTTGGTGTGAGCAGTTTGCAACTTTTTGTTCAGAGCAACTGGACGGGGCCCCCTGTTGACTTACACCCTCAGGAC TTTTTGTCATCTGTTTTGTTCCAGCAATTCAGTGAGGTTAAAGGACTGGATGCATTTGTTCTGAGCCTGCTCACTCTAGATGGTGAATCA ATCTACAGCCTGACCTCGAAGCCTATACTACTGTTATTAGCACGCATTATCCTAGTGAATGTAAGACATAAACTGACAGCTATTCAGAGC TTGCCATGGTGGACTTTGAGATGTGTGAATATTCATCAGCATTTGCTTGAGGAACGCTCACCTCTGCTTTTTACTCTTGCCGAAAACTGT ATTGATCAAGTGATGAAACTACAGAATCTGTTTGTAGATGATTCAGGTCGATATTTGGCTATTCAATTCCATCTGGAATGTGCATATGTG TTTTTATATTATTATGAGTACAGAAAAGCAAAAGATCAGTTGGATATTGCTAAGGACATCAGCCAATTACAAATTGATTTGACAGGTGCT TTGGGAAAAAGAACACGGTTCCAGGAAAATTATGTGGCACAACTGATTCTAGATGTAAGAAGGGAAGGGGATGTCCTTTCAAATTGTGAA TTCACTCCAGCACCCACTCCTCAGGAACATTTAACCAAGAATCTTGAGCTCAATGATGACACCATTCTGAATGACATAAAGTTAGCAGAT TGTGAACAGTTCCAGATGCCGGATCTGTGTGCTGAAGAGATCGCTATTATTCTTGGAATCTGCACTAATTTTCAAAAGAATAACCCAGTG CACACATTAACTGAAGTGGAGCTTCTGGCATTTACATCATGTTTGCTTTCACAACCAAAGTTCTGGGCCATTCAGACATCAGCCTTGATC CTCCGGACAAAACTTGAGAAAGGAAGTACTCGCCGAGTGGAACGGGCAATGAGGCAGACACAGGCTCTTGCAGACCAATTTGAAGATAAA ACTACATCTGTATTGGAACGCCTGAAGATTTTCTATTGCTGTCAAGTACCACCTCACTGGGCCATTCAGCGCCAACTTGCAAGTTTGCTC TTTGAGTTGGGATGTACCAGTTCAGCCCTTCAGATATTTGAAAAGCTAGAAATGTGGGAAGATGTTGTCATTTGTTATGAAAGAGCCGGG CAGCACGGAAAGGTTTGTTTAAGCATCTTAAACACGTGGCATGGAAGACCAGAAGAGAAGTGGAATCCTCAGACCTCAAGCTTTTTGCAA GTGTTGGTGTCTGTCCAGTCCCTTATATTAGTAGCTGAGCCTTATTTTAATGAACCGGGATATGAACGGTCTAGAGGCACTCCCAGTGGC ACACAGAGTTCTCGAGAATATGATGGAAACATTCGACAAGCAACAGTTAAGTGGGCAATGCTAGAACAAATCAGAAACCCTTCACCATGT TTTAAAGAGGTAATACACAAACATTTTTACTTGAAAAGAGTTGAGATAATGGCCCAATGTGAGGAGTGGATTGCGGATATCCAGCAGTAC AGCAGTGATAAGCGGGTAGGCAGGACTATGTCTCACCATGCAGCAGCTCTCAAGCGTCACACTGCTCAGCTCCGCGAAGAGTTGCTGAAA CTTCCCTGCCCTGAAGGCTTGGATCCTGACACTGACGATGCCCCAGAGGTGTGCAGAGCCACAACAGGTGCTGAGGAGACTCTAATGCAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TTC27_ENST00000317907_chr2_32961883_+_BIRC6_ENST00000421745_chr2_32828073_+_3260nt GGAAGCCAGACCAGAGAGCGTGCGTGTTTTTCCCAGGGTGCCCCGCGCTGCTGTTATGGCCGCCTCCTTGAGGTAGTATCCGCACATGGA ATTCTAGGGCCGCAGGTGTATTTACGGTAACTGTCGCCACTAGATTTCAGCGCCTTTGGACTCTCCTGTTTTCACTTTCTTTTGTTGACT CCCGTGTGGCCCTCGTGGGAGCCTGTTTTGGCTGCAGCGGTGTCTGGGGTGATGTGGACCCCGGAGCTGGCAATTCTGAGGGGATTCCCC ACTGAGGCTGAGCGGCAGCAATGGAAACAGGAGGGGGTCGTCGGTTCAGAGAGTGGATCTTTCCTACAATTGCTACTGGAAGGGAACTAT GAAGCCATATTCTTAAATTCAATGACTCAAAATATTTTTAATTCAACAACAACCGCTGAAGAAAAGATTGATAGCTACCTGGAGAAGCAG GTAGTAACATTCCTGGATTACTCAACAGATTTGGACACAACGGAAAGACAACAGTTGATATTTCTACTTGGTGTGAGCAGTTTGCAACTT TTTGTTCAGAGCAACTGGACGGGGCCCCCTGTTGACTTACACCCTCAGGACTTTTTGTCATCTGTTTTGTTCCAGCAATTCAGTGAGGTT AAAGGACTGGATGCATTTGTTCTGAGCCTGCTCACTCTAGATGGTGAATCAATCTACAGCCTGACCTCGAAGCCTATACTACTGTTATTA GCACGCATTATCCTAGTGAATGTAAGACATAAACTGACAGCTATTCAGAGCTTGCCATGGTGGACTTTGAGATGTGTGAATATTCATCAG CATTTGCTTGAGGAACGCTCACCTCTGCTTTTTACTCTTGCCGAAAACTGTATTGATCAAGTGATGAAACTACAGAATCTGTTTGTAGAT GATTCAGGTCGATATTTGGCTATTCAATTCCATCTGGAATGTGCATATGTGTTTTTATATTATTATGAGTACAGAAAAGCAAAAGATCAG TTGGATATTGCTAAGGACATCAGCCAATTACAAATTGATTTGACAGGTGCTTTGGGAAAAAGAACACGGTTCCAGGAAAATTATGTGGCA CAACTGATTCTAGATGTAAGAAGGGAAGGGGATGTCCTTTCAAATTGTGAATTCACTCCAGCACCCACTCCTCAGGAACATTTAACCAAG AATCTTGAGCTCAATGATGACACCATTCTGAATGACATAAAGTTAGCAGATTGTGAACAGTTCCAGATGCCGGATCTGTGTGCTGAAGAG ATCGCTATTATTCTTGGAATCTGCACTAATTTTCAAAAGAATAACCCAGTGCACACATTAACTGAAGTGGAGCTTCTGGCATTTACATCA TGTTTGCTTTCACAACCAAAGTTCTGGGCCATTCAGACATCAGCCTTGATCCTCCGGACAAAACTTGAGAAAGGAAGTACTCGCCGAGTG GAACGGGCAATGAGGCAGACACAGGCTCTTGCAGACCAATTTGAAGATAAAACTACATCTGTATTGGAACGCCTGAAGATTTTCTATTGC TGTCAAGTACCACCTCACTGGGCCATTCAGCGCCAACTTGCAAGTTTGCTCTTTGAGTTGGGATGTACCAGTTCAGCCCTTCAGATATTT GAAAAGCTAGAAATGTGGGAAGATGTTGTCATTTGTTATGAAAGAGCCGGGCAGCACGGAAAGGTTTGTTTAAGCATCTTAAACACGTGG CATGGAAGACCAGAAGAGAAGTGGAATCCTCAGACCTCAAGCTTTTTGCAAGTGTTGGTGTCTGTCCAGTCCCTTATATTAGTAGCTGAG CCTTATTTTAATGAACCGGGATATGAACGGTCTAGAGGCACTCCCAGTGGCACACAGAGTTCTCGAGAATATGATGGAAACATTCGACAA GCAACAGTTAAGTGGGCAATGCTAGAACAAATCAGAAACCCTTCACCATGTTTTAAAGAGGTAATACACAAACATTTTTACTTGAAAAGA GTTGAGATAATGGCCCAATGTGAGGAGTGGATTGCGGATATCCAGCAGTACAGCAGTGATAAGCGGGTAGGCAGGACTATGTCTCACCAT GCAGCAGCTCTCAAGCGTCACACTGCTCAGCTCCGCGAAGAGTTGCTGAAACTTCCCTGCCCTGAAGGCTTGGATCCTGACACTGACGAT GCCCCAGAGGTGTGCAGAGCCACAACAGGTGCTGAGGAGACTCTAATGCATGATCAGGTTAAACCCAGCAGCAGCAAAGAACTCCCCAGT GACTTCCAGTTATGAGCTGCATTGATGTGGACTTCATAGACACAAAGGCTTCGAAGCACAAGCCAAATATGTCAATATTTGTATGTAAGA AACTAATTATGTAATAGGTAATGAAACTGAAACTATACTATGCCCTTAAGGAGATCCAGTTTAATTCAAGGTGATCTTTTATTTACCTGT ACAGGAGTGTAAACTTTTTTGTGCTTTTATTTTTCAATTGTGAGAACCACTGATTGGTATGTTCAACAAATTTGTGTATACAAAGAAATG GATAAATCACTGCTATATAAGGGAAACTACCTTAGGAAAGAATGTTTACTGAATGTTTATTTTATTTTATTTTTTTTTTACTATAGAGTG AGGGGTTGTTAACAAAGAATATATATTGGTCATTCTTACAACTACTATTTAAAGTCAGCAACTTTTCACTGAATTTGATAGATTTTATGT TTGGCCATATCTTCATGCTCACATTTGATTTCTGAAGACCTCCTACATACACTTCAATAAAAGTTAAATGGACATACTCCCTCTTTTTTG ATTTACTGGTACATTTTTAAAATAATAAATCTGCCATAAAATGCATTATATCTGGAGACTTGCACTTGTATGGATGAATTTATTACATTC AACATATTTAATTTTATGCCTTCTAATTCTAAGATGCAGAAAAAAATAAATGAACATGATTTTATTCTATGCCAACATTTGGGCCTCTGA ATGTATCTGTTATTTGAATTTAAGTATTTGAAAAGGAATGGTCAATTTGAAAGTCATTCTAAACTGATTTTTTTTTTCTAAAGGGCTCCT TTTTTCCTGGACTATGTGGTTTTATGACTAAAGTCACATGTATGTATTAAACATTGAGGCTCTGTAGAGGAGAGAGGATGTACCTCTCTG GTGCTGTTACAGTACATTCTGTACCTGCCATACAGGCTCATTTTCATGCAAATTCTTCCTAGAGCCAAATAAATAAAGACTTAGGTGAAT |
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FusionGenePPI for TTC27_BIRC6 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TTC27 | PHLDA3, PTP4A3, MYC, TXLNA, NPM1, HDAC11, EGFR, FBXO6, C10orf76, CD2AP, GFPT1, MAPK3, NMD3, PPP2R5D, SKIV2L2, ASNS, CSTF1, CSTF2, DHX15, UFD1L, NTRK1, KRAS, FBXL12, FAF2, TTC27, EFTUD2, SNRNP200, PRPF8, CCT5, CCT6A, CCT4, CCT7, CCT2, AAR2, TCP1, CCT3, NCDN, ECD, TRIM25 | BIRC6 | RNF41, KIF23, USP8, DIABLO, CASP9, HTRA2, UBC, VAV2, SIRT7, CASP3, CASP7, BIRC6, CASP8, UBE2D1, CSNK2A1, RASSF2, EPS15L1, GBF1, CCNA2, CDC27, ANAPC11, TEX35, PRSS45, RTBDN, C3orf20, WDR4, DFNA5, FAM175B, CA11, FIGF, MOS, HERC2, CHIA, CLEC11A, INTS4P2, TBC1D22A, FAM58A, MCPH1, TP53, UNK, RPGR, KIF22, LLGL2, PLK1, MYH13, SSH3, AGRP, ANGPTL3, UGGT2, AKAP9, DCAF12, FERMT2, PSMC5, MGST3, CCDC22, OSBPL2, ADAMTS4, HEY1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TTC27_BIRC6 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TTC27_BIRC6 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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