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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39930

FusionGeneSummary for TTC1_IL32

check button Fusion gene summary
Fusion gene informationFusion gene name: TTC1_IL32
Fusion gene ID: 39930
HgeneTgene
Gene symbol

TTC1

IL32

Gene ID

7265

9235

Gene nametetratricopeptide repeat domain 1interleukin 32
SynonymsTPR1IL-32alpha|IL-32beta|IL-32delta|IL-32gamma|NK4|TAIF|TAIFa|TAIFb|TAIFc|TAIFd
Cytomap

5q33.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptiontetratricopeptide repeat protein 1TPR repeat protein 1interleukin-32interleukin-32 etainterleukin-32 smallinterleukin-32 thetanatural killer cell transcript 4natural killer cells protein 4tumor necrosis factor alpha-inducing factor
Modification date2018052220180519
UniProtAcc

Q99614

P24001

Ensembl transtripts involved in fusion geneENST00000522793, ENST00000231238, 
ENST00000520274, 
ENST00000325568, 
ENST00000534507, ENST00000531965, 
ENST00000396887, ENST00000529699, 
ENST00000526464, ENST00000440815, 
ENST00000529550, ENST00000551122, 
ENST00000525643, ENST00000528163, 
ENST00000530890, ENST00000444393, 
ENST00000533097, ENST00000008180, 
ENST00000396890, ENST00000548652, 
ENST00000530538, ENST00000549213, 
ENST00000552936, ENST00000548476, 
ENST00000552664, ENST00000552356, 
ENST00000551513, ENST00000382213, 
ENST00000548246, 
Fusion gene scores* DoF score6 X 6 X 2=723 X 3 X 2=18
# samples 73
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TTC1 [Title/Abstract] AND IL32 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW380713TTC1chr5

159492039

+IL32chr16

3119031

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000522793ENST00000325568TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000534507TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000531965TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000396887TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000529699TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000526464TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000440815TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000529550TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000551122TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000525643TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000528163TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000530890TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000444393TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000533097TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000008180TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000396890TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000548652TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000530538TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000549213TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000552936TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000548476TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000552664TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000552356TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000522793ENST00000551513TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000382213TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000522793ENST00000548246TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000325568TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000534507TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000531965TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000396887TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000529699TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000231238ENST00000526464TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000440815TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000529550TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000551122TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000525643TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000231238ENST00000528163TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000530890TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000444393TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000533097TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000231238ENST00000008180TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000396890TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000548652TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000231238ENST00000530538TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000549213TTC1chr5

159492039

+IL32chr16

3119031

-
In-frameENST00000231238ENST00000552936TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000548476TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000552664TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000552356TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000551513TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000382213TTC1chr5

159492039

+IL32chr16

3119031

-
Frame-shiftENST00000231238ENST00000548246TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000325568TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000534507TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000531965TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000396887TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000529699TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000526464TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000440815TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000529550TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000551122TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000525643TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000528163TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000530890TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000444393TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000533097TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000008180TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000396890TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000548652TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000530538TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000549213TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000552936TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000548476TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000552664TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000552356TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000551513TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000382213TTC1chr5

159492039

+IL32chr16

3119031

-
3UTR-3CDSENST00000520274ENST00000548246TTC1chr5

159492039

+IL32chr16

3119031

-

Top

FusionProtFeatures for TTC1_IL32


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTC1

Q99614

IL32

P24001


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTC1_IL32


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TTC1_IL32


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TTC1_IL32


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TTC1_IL32


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIL32C0009375Colonic Neoplasms1CTD_human
TgeneIL32C0022665Kidney Neoplasm1CTD_human
TgeneIL32C0036920Sezary Syndrome1CTD_human
TgeneIL32C0038356Stomach Neoplasms1CTD_human
TgeneIL32C0162820Dermatitis, Allergic Contact1CTD_human