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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39914

FusionGeneSummary for TTBK2_ZNF106

check button Fusion gene summary
Fusion gene informationFusion gene name: TTBK2_ZNF106
Fusion gene ID: 39914
HgeneTgene
Gene symbol

TTBK2

ZNF106

Gene ID

146057

64397

Gene nametau tubulin kinase 2zinc finger protein 106
SynonymsSCA11|TTBKSH3BP3|ZFP106|ZNF474
Cytomap

15q15.2

15q15.1

Type of geneprotein-codingprotein-coding
Descriptiontau-tubulin kinase 2zinc finger protein 106SH3-domain binding protein 3zinc finger protein 474
Modification date2018052320180523
UniProtAcc

Q6IQ55

Q9H2Y7

Ensembl transtripts involved in fusion geneENST00000267890, ENST00000567840, 
ENST00000567274, ENST00000567485, 
ENST00000263805, ENST00000565380, 
ENST00000565611, ENST00000565660, 
Fusion gene scores* DoF score6 X 4 X 6=1444 X 5 X 3=60
# samples 66
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/60*10)=0
Context

PubMed: TTBK2 [Title/Abstract] AND ZNF106 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTTBK2

GO:0007026

negative regulation of microtubule depolymerization

26323690

HgeneTTBK2

GO:0018105

peptidyl-serine phosphorylation

21548880|26323690

HgeneTTBK2

GO:1904527

negative regulation of microtubule binding

26323690


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-AA-3697-01ATTBK2chr15

43132558

-ZNF106chr15

42710149

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000267890ENST00000263805TTBK2chr15

43132558

-ZNF106chr15

42710149

-
Frame-shiftENST00000267890ENST00000565380TTBK2chr15

43132558

-ZNF106chr15

42710149

-
Frame-shiftENST00000267890ENST00000565611TTBK2chr15

43132558

-ZNF106chr15

42710149

-
5CDS-intronENST00000267890ENST00000565660TTBK2chr15

43132558

-ZNF106chr15

42710149

-
Frame-shiftENST00000567840ENST00000263805TTBK2chr15

43132558

-ZNF106chr15

42710149

-
Frame-shiftENST00000567840ENST00000565380TTBK2chr15

43132558

-ZNF106chr15

42710149

-
Frame-shiftENST00000567840ENST00000565611TTBK2chr15

43132558

-ZNF106chr15

42710149

-
5CDS-intronENST00000567840ENST00000565660TTBK2chr15

43132558

-ZNF106chr15

42710149

-
Frame-shiftENST00000567274ENST00000263805TTBK2chr15

43132558

-ZNF106chr15

42710149

-
Frame-shiftENST00000567274ENST00000565380TTBK2chr15

43132558

-ZNF106chr15

42710149

-
Frame-shiftENST00000567274ENST00000565611TTBK2chr15

43132558

-ZNF106chr15

42710149

-
5CDS-intronENST00000567274ENST00000565660TTBK2chr15

43132558

-ZNF106chr15

42710149

-
intron-3CDSENST00000567485ENST00000263805TTBK2chr15

43132558

-ZNF106chr15

42710149

-
intron-3CDSENST00000567485ENST00000565380TTBK2chr15

43132558

-ZNF106chr15

42710149

-
intron-3CDSENST00000567485ENST00000565611TTBK2chr15

43132558

-ZNF106chr15

42710149

-
intron-intronENST00000567485ENST00000565660TTBK2chr15

43132558

-ZNF106chr15

42710149

-

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FusionProtFeatures for TTBK2_ZNF106


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TTBK2

Q6IQ55

ZNF106

Q9H2Y7

Serine/threonine kinase that acts as a key regulator ofciliogenesis: controls the initiation of ciliogenesis by bindingto the distal end of the basal body and promoting the removal ofCCP110, which caps the mother centriole, leading to therecruitment of IFT proteins, which build the ciliary axoneme. Hassome substrate preference for proteins that are alreadyphosphorylated on a Tyr residue at the +2 position relative to thephosphorylation site. Able to phosphorylate tau on serines invitro. {ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TTBK2_ZNF106


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TTBK2_ZNF106


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TTBK2TTBK1, ZWINT, PTEN, COPS5, CEP164, KLHL12, FKBP15, MCM2ZNF106WNK1, UBE2I, APC, SKIL, NXF1, CSNK2A2, CLEC11A, CAPZA2, GAK, EXOSC9, PPP1CB, MATR3, GTSE1, KIF21A, KNOP1, KLHL40, NXF2, FBXL5, PLOD1, STAMBPL1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TTBK2_ZNF106


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TTBK2_ZNF106


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTTBK2C0087012Ataxia, Spinocerebellar1CTD_human