FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39889

FusionGeneSummary for TSPO_CDH18

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPO_CDH18
Fusion gene ID: 39889
HgeneTgene
Gene symbol

TSPO

CDH18

Gene ID

706

1016

Gene nametranslocator proteincadherin 18
SynonymsBPBS|BZRP|DBI|IBP|MBR|PBR|PBS|PKBS|PTBR|mDRC|pk18CDH14|CDH14L|CDH24
Cytomap

22q13.2

5p14.3

Type of geneprotein-codingprotein-coding
Descriptiontranslocator proteinbenzodiazepine peripheral binding sitemitochondrial benzodiazepine receptorperipheral-type benzodiazepine receptorcadherin-18cadherin 18, type 2cadherin-14cadherin-like 24ey-cadherin
Modification date2018052320180523
UniProtAcc

P30536

Q13634

Ensembl transtripts involved in fusion geneENST00000337554, ENST00000396265, 
ENST00000583777, ENST00000329563, 
ENST00000382275, ENST00000507958, 
ENST00000502796, ENST00000511273, 
ENST00000274170, ENST00000506372, 
ENST00000510297, 
Fusion gene scores* DoF score3 X 2 X 2=129 X 6 X 6=324
# samples 29
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSPO [Title/Abstract] AND CDH18 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-FS-A4F4-06ATSPOchr22

43557196

+CDH18chr5

19981287

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000337554ENST00000382275TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000337554ENST00000507958TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000337554ENST00000502796TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000337554ENST00000511273TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000337554ENST00000274170TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000337554ENST00000506372TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000337554ENST00000510297TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000396265ENST00000382275TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000396265ENST00000507958TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000396265ENST00000502796TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000396265ENST00000511273TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000396265ENST00000274170TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000396265ENST00000506372TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000396265ENST00000510297TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000583777ENST00000382275TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000583777ENST00000507958TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000583777ENST00000502796TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000583777ENST00000511273TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000583777ENST00000274170TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000583777ENST00000506372TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000583777ENST00000510297TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000329563ENST00000382275TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000329563ENST00000507958TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-5UTRENST00000329563ENST00000502796TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000329563ENST00000511273TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000329563ENST00000274170TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000329563ENST00000506372TSPOchr22

43557196

+CDH18chr5

19981287

-
5CDS-intronENST00000329563ENST00000510297TSPOchr22

43557196

+CDH18chr5

19981287

-

Top

FusionProtFeatures for TSPO_CDH18


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPO

P30536

CDH18

Q13634

Can bind protoporphyrin IX and may play a role in thetransport of porphyrins and heme (By similarity). Promotes thetransport of cholesterol across mitochondrial membranes and mayplay a role in lipid metabolism (PubMed:24814875), but its precisephysiological role is controversial. It is apparently not requiredfor steroid hormone biosynthesis. Was initially identified asperipheral-type benzodiazepine receptor; can also bindisoquinoline carboxamides (PubMed:1847678). {ECO:0000250,ECO:0000269|PubMed:1847678, ECO:0000269|PubMed:24814875}. Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TSPO_CDH18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TSPO_CDH18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TSPOBZRAP1, CREB3L1, ARF4, ATP5F1, CISD1, ATP5A1, ATP5L, ATP5O, VDAC1, VDAC2, VDAC3, CRABP1, SLC2A12, SLC5A8CDH18CTNNB1, CDH6, CDH18, MYOG


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TSPO_CDH18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneTSPOP30536DB00186LorazepamTranslocator proteinsmall moleculeapproved
HgeneTSPOP30536DB01198ZopicloneTranslocator proteinsmall moleculeapproved
HgeneTSPOP30536DB01587KetazolamTranslocator proteinsmall moleculeapproved
HgeneTSPOP30536DB01068ClonazepamTranslocator proteinsmall moleculeapproved|illicit
HgeneTSPOP30536DB01544FlunitrazepamTranslocator proteinsmall moleculeapproved|illicit
HgeneTSPOP30536DB00962ZaleplonTranslocator proteinsmall moleculeapproved|illicit|investigational
HgeneTSPOP30536DB00829DiazepamTranslocator proteinsmall moleculeapproved|illicit|investigational|vet_approved
HgeneTSPOP30536DB00231TemazepamTranslocator proteinsmall moleculeapproved|investigational
HgeneTSPOP30536DB00402EszopicloneTranslocator proteinsmall moleculeapproved|investigational
HgeneTSPOP30536DB00897TriazolamTranslocator proteinsmall moleculeapproved|investigational
HgeneTSPOP30536DB01178ChlormezanoneTranslocator proteinsmall moleculeapproved|investigational|withdrawn

Top

RelatedDiseases for TSPO_CDH18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTSPOC0019151Hepatic Encephalopathy2CTD_human
HgeneTSPOC0005586Bipolar Disorder1PSYGENET
HgeneTSPOC0023893Liver Cirrhosis, Experimental1CTD_human
HgeneTSPOC0745744End Stage Liver Disease1CTD_human
TgeneCDH18C0001973Alcoholic Intoxication, Chronic1PSYGENET