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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39884

FusionGeneSummary for TSPAN9_TMEM200A

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN9_TMEM200A
Fusion gene ID: 39884
HgeneTgene
Gene symbol

TSPAN9

TMEM200A

Gene ID

10867

114801

Gene nametetraspanin 9transmembrane protein 200A
SynonymsNET-5|NET5|PP1057KIAA1913|TTMA|TTMC
Cytomap

12p13.33-p13.32

6q23.1

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-9new EST tetraspan 5tetraspan NET-5transmembrane 4 superfamily member tetraspan NET-5tspan-9transmembrane protein 200Atwo transmembrane C
Modification date2018052320180519
UniProtAcc

O75954

Q86VY9

Ensembl transtripts involved in fusion geneENST00000537971, ENST00000011898, 
ENST00000407263, ENST00000492305, 
ENST00000296978, ENST00000545622, 
ENST00000392429, 
Fusion gene scores* DoF score16 X 9 X 7=10083 X 2 X 2=12
# samples 143
** MAII scorelog2(14/1008*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TSPAN9 [Title/Abstract] AND TMEM200A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSARCTCGA-JV-A5VF-01ATSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000537971ENST00000296978TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
5UTR-5UTRENST00000537971ENST00000545622TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
5UTR-5UTRENST00000537971ENST00000392429TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
5UTR-5UTRENST00000011898ENST00000296978TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
5UTR-5UTRENST00000011898ENST00000545622TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
5UTR-5UTRENST00000011898ENST00000392429TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
intron-5UTRENST00000407263ENST00000296978TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
intron-5UTRENST00000407263ENST00000545622TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
intron-5UTRENST00000407263ENST00000392429TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
intron-5UTRENST00000492305ENST00000296978TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
intron-5UTRENST00000492305ENST00000545622TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+
intron-5UTRENST00000492305ENST00000392429TSPAN9chr12

3186619

+TMEM200Achr6

130761552

+

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FusionProtFeatures for TSPAN9_TMEM200A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN9

O75954

TMEM200A

Q86VY9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSPAN9_TMEM200A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSPAN9_TMEM200A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TSPAN9ELAVL1TMEM200ATP53, PPP3CC, FHOD1, PPP3CB, PPP3R1, MYADM, STX6, STX10, PPP3CA, GOSR1, STX7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSPAN9_TMEM200A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSPAN9_TMEM200A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource