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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 39861

FusionGeneSummary for TSPAN5_PKD2

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN5_PKD2
Fusion gene ID: 39861
HgeneTgene
Gene symbol

TSPAN5

PKD2

Gene ID

10098

25865

Gene nametetraspanin 5protein kinase D2
SynonymsNET-4|NET4|TM4SF9|TSPAN-5HSPC187|PKD2|nPKC-D2
Cytomap

4q23

19q13.32

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8serine/threonine-protein kinase D2
Modification date2018052320180523
UniProtAcc

P62079

Q13563

Ensembl transtripts involved in fusion geneENST00000305798, ENST00000505184, 
ENST00000509168, 		ENST00000237596, 
ENST00000508588, ENST00000511337, 
ENST00000502363, 
Fusion gene scores* DoF score4 X 2 X 4=322 X 2 X 2=8
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: TSPAN5 [Title/Abstract] AND PKD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePKD2

GO:0006468

protein phosphorylation

22228765

TgenePKD2

GO:0018105

peptidyl-serine phosphorylation

18440775

TgenePKD2

GO:0045944

positive regulation of transcription by RNA polymerase II

17077180

TgenePKD2

GO:0046777

protein autophosphorylation

17077180

TgenePKD2

GO:0050852

T cell receptor signaling pathway

17077180


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A243-01ATSPAN5chr4

99579297

-PKD2chr4

88973143

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000305798ENST00000237596TSPAN5chr4

99579297

-PKD2chr4

88973143

+
5CDS-5UTRENST00000305798ENST00000508588TSPAN5chr4

99579297

-PKD2chr4

88973143

+
5CDS-intronENST00000305798ENST00000511337TSPAN5chr4

99579297

-PKD2chr4

88973143

+
5CDS-intronENST00000305798ENST00000502363TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-3CDSENST00000505184ENST00000237596TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-5UTRENST00000505184ENST00000508588TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-intronENST00000505184ENST00000511337TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-intronENST00000505184ENST00000502363TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-3CDSENST00000509168ENST00000237596TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-5UTRENST00000509168ENST00000508588TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-intronENST00000509168ENST00000511337TSPAN5chr4

99579297

-PKD2chr4

88973143

+
intron-intronENST00000509168ENST00000502363TSPAN5chr4

99579297

-PKD2chr4

88973143

+

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FusionProtFeatures for TSPAN5_PKD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN5

P62079

PKD2

Q13563

Regulates ADAM10 maturation and trafficking to the cellsurface. Promotes ADAM10-mediated cleavage of CD44.{ECO:0000269|PubMed:26686862}. Functions as a cation channel involved in fluid-flowmechanosensation by the primary cilium in renal epithelium(PubMed:18695040). Functions as outward-rectifying K(+) channel,but is also permeable to Ca(2+), and to a much lesser degree alsoto Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085,PubMed:27991905). May contribute to the release of Ca(2+) storesfrom the endoplasmic reticulum (PubMed:11854751, PubMed:20881056).Together with TRPV4, forms mechano- and thermosensitive channelsin cilium (PubMed:18695040). PKD1 and PKD2 may function through acommon signaling pathway that is necessary to maintain the normal,differentiated state of renal tubule cells. Acts as a regulator ofcilium length, together with PKD1. The dynamic control of ciliumlength is essential in the regulation of mechanotransductivesignaling. The cilium length response creates a negative feedbackloop whereby fluid shear-mediated deflection of the primarycilium, which decreases intracellular cAMP, leads to ciliumshortening and thus decreases flow-induced signaling. Alsoinvolved in left-right axis specification via its role in sensingnodal flow; forms a complex with PKD1L1 in cilia to facilitateflow detection in left-right patterning. Detection of asymmetricnodal flow gives rise to a Ca(2+) signal that is required fornormal, asymmetric expression of genes involved in thespecification of body left-right laterality (By similarity).{ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751,ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:16551655,ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:20881056,ECO:0000269|PubMed:27991905, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-181_1727269Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515763_774516969Calcium bindingOntology_term=ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515833_872516969Coiled coilOntology_term=ECO:0000269,ECO:0000305
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515750_785516969DomainEF-hand
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515632_646516969IntramembranePore-forming
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515641_643516969MotifSelectivity filter
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515803_822516969RegionLinker
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515527_552516969Topological domainExtracellular
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515574_597516969Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515620_631516969Topological domainExtracellular
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515647_654516969Topological domainExtracellular
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515676_968516969Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515553_573516969TransmembraneHelical%3B Name%3DS4
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515598_619516969TransmembraneHelical%3B Name%3D5
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515655_675516969TransmembraneHelical%3B Name%3DS6

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-18114_23227269Topological domainExtracellular
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-18254_26827269Topological domainCytoplasmic
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1839_6127269Topological domainExtracellular
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1883_9227269Topological domainCytoplasmic
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1818_3827269TransmembraneHelical
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-18233_25327269TransmembraneHelical
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1862_8227269TransmembraneHelical
HgeneTSPAN5chr4:99579297chr4:88973143ENST00000305798-1893_11327269TransmembraneHelical
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515153_157516969Compositional biasNote=Poly-Arg
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+51595_107516969Compositional biasNote=Poly-Glu
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+5151_219516969Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515242_468516969Topological domainExtracellular
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515490_505516969Topological domainCytoplasmic
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515220_241516969TransmembraneHelical%3B Name%3DS1
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515469_489516969TransmembraneHelical%3B Name%3DS2
TgenePKD2chr4:99579297chr4:88973143ENST00000237596+515506_526516969TransmembraneHelical%3B Name%3DS3


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FusionGeneSequence for TSPAN5_PKD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_PKD2_ENST00000237596_chr4_88973143_+_480aa
MSGKHYKGPEVSCCIKYFIFGFNVIFWLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINF
NRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMF
FILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIF
TKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRM
EHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELERWESDDAASQISHGLGTPVGLNGQP


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_PKD2_ENST00000237596_chr4_88973143_+_1440nt
ATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAAATACTTCATATTTGGCTTCAATGTCATATTTTGGCTGTCAGTG
GTAGCTATAGGAATTAACATATACAGAACATCAAATGTGGAGGTGCTACTACAGTTTCTGGAAGATCAAAATACTTTCCCCAACTTTGAG
CATCTGGCATATTGGCAGATACAGTTCAACAATATAGCTGCTGTCACAGTATTTTTTGTCTGGATTAAGCTCTTCAAATTCATCAATTTT
AACAGGACCATGAGCCAGCTCTCGACAACCATGTCTCGATGTGCCAAAGACCTGTTTGGCTTTGCTATTATGTTCTTCATTATTTTCCTA
GCGTATGCTCAGTTGGCATACCTTGTCTTTGGCACTCAGGTCGATGACTTCAGTACTTTCCAAGAGTGTATCTTCACTCAATTCCGTATC
ATTTTGGGCGATATCAACTTTGCAGAGATTGAGGAAGCTAATCGAGTTTTGGGACCAATTTATTTCACTACATTTGTGTTCTTTATGTTC
TTCATTCTTTTGAATATGTTTTTGGCTATCATCAATGATACTTACTCTGAAGTGAAATCTGACTTGGCACAGCAGAAAGCTGAAATGGAA
CTCTCAGATCTTATCAGAAAGGGCTACCATAAAGCTTTGGTCAAACTAAAACTGAAAAAAAATACCGTGGATGACATTTCAGAGAGTCTG
CGGCAAGGAGGAGGCAAGTTAAACTTTGACGAACTTCGACAAGATCTCAAAGGGAAGGGCCATACTGATGCAGAGATTGAGGCAATATTC
ACAAAGTACGACCAAGATGGAGACCAAGAACTGACCGAACATGAACATCAGCAGATGAGAGACGACTTGGAGAAAGAGAGGGAGGACCTG
GATTTGGATCACAGTTCTTTACCACGTCCCATGAGCAGCCGAAGTTTCCCTCGAAGCCTGGATGACTCTGAGGAGGATGACGATGAAGAT
AGCGGACATAGCTCCAGAAGGAGGGGAAGCATTTCTAGTGGCGTTTCTTACGAAGAGTTTCAAGTCCTGGTGAGACGAGTGGACCGGATG
GAGCATTCCATCGGCAGCATAGTGTCCAAGATTGACGCCGTGATCGTGAAGCTAGAGATTATGGAGCGAGCCAAACTGAAGAGGAGGGAG
GTGCTGGGAAGGCTGTTGGATGGGGTGGCCGAGGATGAAAGGCTGGGTCGTGACAGTGAAATCCATAGGGAACAGATGGAACGGCTAGTA
CGTGAAGAGTTGGAACGCTGGGAATCCGATGATGCAGCTTCCCAGATCAGTCATGGTTTAGGCACGCCAGTGGGACTAAATGGTCAACCT
CGCCCCAGAAGCTCCCGCCCATCTTCCTCCCAATCTACAGAAGGCATGGAAGGTGCAGGTGGAAATGGGAGTTCTAATGTCCACGTATGA


* Fusion transcript sequences (Full-length transcript).
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_PKD2_ENST00000237596_chr4_88973143_+_3926nt
GCGAACGGGCGGGCGAGCAAGCGAGCGGCGTCTCCACCAGCATCTGCCGCGGCCGCCTTTGCCCGAAGCCCGGGGACGAACCGACGGACC
GACCGCCTGGCGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTT
TCTCGCGGCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTG
AGCCCAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTC
CAAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAA
ATACTTCATATTTGGCTTCAATGTCATATTTTGGCTGTCAGTGGTAGCTATAGGAATTAACATATACAGAACATCAAATGTGGAGGTGCT
ACTACAGTTTCTGGAAGATCAAAATACTTTCCCCAACTTTGAGCATCTGGCATATTGGCAGATACAGTTCAACAATATAGCTGCTGTCAC
AGTATTTTTTGTCTGGATTAAGCTCTTCAAATTCATCAATTTTAACAGGACCATGAGCCAGCTCTCGACAACCATGTCTCGATGTGCCAA
AGACCTGTTTGGCTTTGCTATTATGTTCTTCATTATTTTCCTAGCGTATGCTCAGTTGGCATACCTTGTCTTTGGCACTCAGGTCGATGA
CTTCAGTACTTTCCAAGAGTGTATCTTCACTCAATTCCGTATCATTTTGGGCGATATCAACTTTGCAGAGATTGAGGAAGCTAATCGAGT
TTTGGGACCAATTTATTTCACTACATTTGTGTTCTTTATGTTCTTCATTCTTTTGAATATGTTTTTGGCTATCATCAATGATACTTACTC
TGAAGTGAAATCTGACTTGGCACAGCAGAAAGCTGAAATGGAACTCTCAGATCTTATCAGAAAGGGCTACCATAAAGCTTTGGTCAAACT
AAAACTGAAAAAAAATACCGTGGATGACATTTCAGAGAGTCTGCGGCAAGGAGGAGGCAAGTTAAACTTTGACGAACTTCGACAAGATCT
CAAAGGGAAGGGCCATACTGATGCAGAGATTGAGGCAATATTCACAAAGTACGACCAAGATGGAGACCAAGAACTGACCGAACATGAACA
TCAGCAGATGAGAGACGACTTGGAGAAAGAGAGGGAGGACCTGGATTTGGATCACAGTTCTTTACCACGTCCCATGAGCAGCCGAAGTTT
CCCTCGAAGCCTGGATGACTCTGAGGAGGATGACGATGAAGATAGCGGACATAGCTCCAGAAGGAGGGGAAGCATTTCTAGTGGCGTTTC
TTACGAAGAGTTTCAAGTCCTGGTGAGACGAGTGGACCGGATGGAGCATTCCATCGGCAGCATAGTGTCCAAGATTGACGCCGTGATCGT
GAAGCTAGAGATTATGGAGCGAGCCAAACTGAAGAGGAGGGAGGTGCTGGGAAGGCTGTTGGATGGGGTGGCCGAGGATGAAAGGCTGGG
TCGTGACAGTGAAATCCATAGGGAACAGATGGAACGGCTAGTACGTGAAGAGTTGGAACGCTGGGAATCCGATGATGCAGCTTCCCAGAT
CAGTCATGGTTTAGGCACGCCAGTGGGACTAAATGGTCAACCTCGCCCCAGAAGCTCCCGCCCATCTTCCTCCCAATCTACAGAAGGCAT
GGAAGGTGCAGGTGGAAATGGGAGTTCTAATGTCCACGTATGATATGTGTGTTTCAGTATGTGTGTTTCTAATAAGTGAGGAAGTGGCTG
TCCTGAATTGCTGTAACAAGCACACTATTTATATGCCCTGACCACCATAGGATGCTAGTCTTTGTGACCGATTGCTAATCTTCTGCACTT
TAATTTATTTTATATAAACTTTACCCATGGTTCAAAGATTTTTTTTTCTTTTTCTCATATAAGAAATCTAGGTGTAAATATTGAGTACAG
AAAAAAAATCTTCATGATGTGTATTGAGCGGTACGCCCAGTTGCCACCATGACTGAGTCTTCTCAGTTGACAATGAAGTAGCCTTTTAAA
GCTAGAAAACTGTCAAAGGGCTTCTGAGTTTCATTTCCAGTCACAAAAATCAGTATTGTTATTTTTTTCCAAGAGTGTGAAGGAAAATGG
GGCATTCCTTTCCACTCTGGCATAGTTCATGAGCTTAATACATAGCTTTCTTTTAAGAAAGGAGCCTTTTTTTTCAACTAGCTTCCTGGG
GTAAACTTTTCTAAAAGATAAAATGGAAAGGAACTCCAAACTATGATAGAATCTGTGTGAATGGTTAAGATGAATGTTAAATACTATGCT
TTTTTGTAAGTTGATCGTATCTGATGTCTGTGGGACTAACTGTATCACTTAATTTTTACCTTATTTTGGCTCTAATTTGAATAAGCTGAG
TAAAACCACCAAAGATCAGTTATAGGATAAAATGGCATCTCTAACCATAACACAGGAGAATTGGAAGGAGCCCTAAGTTGTCACTCAGTT
TAATTTCTTTTAATGGTTAGTTTAGCCTAAAGATTTATCTGCATATTCTTTTTCCCATGTGGCTCTACTCATTTGCAACTGAATTTAATG
TTATAACTCATCTAGTGAGACCAACTTACTAAATTTTTAGTATGCACTGAAAGTTTTTATCCAACAATTATGTTCATTTTAAGCAAAATT
TTAAGAAAGTTTTGAAATTCATAAAGCATTTGGTTTTAAACTATTTTAAGAATATAGTACTCGGTCAGGTATGACGGCTCACGCCTGTAA
TCCCAGCACTTTGGGAGGCCGAAACAGGCGAATCACTTGAGCCCAGGAGTTCAAGACCAACATGGGCAATGTGGCGAAACTCCATCTCTA
CAAAAAATGCAAAAATAAAAAATATAGTACTCAAGTATTCTTGATCCTGTGTTTCAAAACTAGAATTTGTAATGCAAATGGAGCTCAGTC
TAATAAAAAAGAGGTTTTGGTATTAAAAGTTCATACATTAGACAGTATCAGCCAAAATTTGAGTTAGCAACACTGTTTTCTTTACGAGAG
GGTCTCACCCAAATTTATGGGGAGAAATCTATTTCTCAAAAAAAAAAATCTTCTTTTACAGAAATGTTGAGTAAGGTGACATTTTGAGCG
CTAATAAGCAAAAGAGCATGCAGTGCTGTTGAATAACCCTCACTTGGAGAACCAAGAGAATCCTGTCGTTTAATGCTATATTTTAATTTC
ACAAGTTGTTCATTTAACTGGTAGAATGTCAGTCCAATCTCCAATGAGAACATGAGCAAATAGACCTTTCCAGGTTGAAAGTGAAACATA
CTGGGTTTCTGTAAGTTTTTCCTCATGGCTTCATCTCTATCTTTACTTTCTCTTGAATATGCTACACAAAGTTCTTTATTACTACATACT
AAAGTTTGCATTCCAGGGATATTGACTGTACATATTTATGTATATGTACCATGTTGTTACATGTAAACAAACTTCAATTTGAAGTGCAGC
TATTATGTGGTATCCATGTGTATCGACCATGTGCCATATATCAATTATGGTCACTAGAAAGTCTCTTTATGATACTTTTTATTGTACTGT
TTTTCATTTCACTTGCAAAATTTTGCAGAATTCCTCCTTTCTACCCATAAATTACATATATTTTTCTTCTTTAGTCATGGAGAACTCCCC
CCCTCATCTCTTCCCTATTATCTTTCCCTGTGTACTGGTATTATTAAAAAGACATTACATACGCAAGTCTTTCTCGACAATCAAGAATGT


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FusionGenePPI for TSPAN5_PKD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TSPAN5APP, ADAM10, TMEM248, VKORC1L1, TMEM87A, ALG8, GDPD1, THAP11, AGPAT4, AGPAT3, SLC27A2, SPCS2, KLHL2, TMEM186, SOAT1, ATP2B3, RDH11, RFT1, GHDC, SLC7A2, TMUB1, SEC62, EFNB1, BSCL2, SC5D, GPR89A, LCLAT1, CD47, SNX25, ZDHHC9, LEMD2, ZDHHC6, IMMP1L, ALG11, NAT8L, TMEM192, RDH12, TMEM43, TMEM206, FTSJ2, NDC1, DAGLB, PSEN2, DNAJC19, TVP23C, WDR41, RDH14, B4GALT1, RER1, FAM210B, FAM134C, SPCS1, PIEZO1, SCAMP2, PRAF2, CYB5R3, NAT14, GP1BB, BRI3BP, ZDHHC21, SLC38A2, FAM213A, TRIM25PKD2PKD1, PKD2, TRPC1, TNNI3, CANX, GOLGA2, ATP1A1, MAGEA8, PLSCR1, KRT40, KRTAP10-8, KRTAP10-3, FAM3D, CEP170, ALG5, GLRA2, BCAS4, PICK1, SRPR, TMEM248, PKD2L2, PTGIR, CRYL1, CHRND, EXOC3, TPTE2, TMPRSS12, COG6, CNGA3, CD300E, GCC2, LMNA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSPAN5_PKD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSPAN5_PKD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePKD2C2751306Polycystic kidney disease, type 26UNIPROT
TgenePKD2C0085413Polycystic Kidney, Autosomal Dominant4CTD_human
TgenePKD2C0023893Liver Cirrhosis, Experimental1CTD_human
TgenePKD2C0035309Retinal Diseases1CTD_human
TgenePKD2C0042373Vascular Diseases1CTD_human
TgenePKD2C0524851Neurodegenerative Disorders1CTD_human