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Fusion gene ID: 39861 |
FusionGeneSummary for TSPAN5_PKD2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TSPAN5_PKD2 | Fusion gene ID: 39861 | Hgene | Tgene | Gene symbol | TSPAN5 | PKD2 | Gene ID | 10098 | 25865 |
Gene name | tetraspanin 5 | protein kinase D2 | |
Synonyms | NET-4|NET4|TM4SF9|TSPAN-5 | HSPC187|PKD2|nPKC-D2 | |
Cytomap | 4q23 | 19q13.32 | |
Type of gene | protein-coding | protein-coding | |
Description | tetraspanin-5tetraspan NET-4tetraspan TM4SFtransmembrane 4 superfamily member 9transmembrane 4 superfamily, member 8 | serine/threonine-protein kinase D2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P62079 | Q13563 | |
Ensembl transtripts involved in fusion gene | ENST00000305798, ENST00000505184, ENST00000509168, | ENST00000237596, ENST00000508588, ENST00000511337, ENST00000502363, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 2 X 2 X 2=8 |
# samples | 4 | 2 | |
** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TSPAN5 [Title/Abstract] AND PKD2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PKD2 | GO:0006468 | protein phosphorylation | 22228765 |
Tgene | PKD2 | GO:0018105 | peptidyl-serine phosphorylation | 18440775 |
Tgene | PKD2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17077180 |
Tgene | PKD2 | GO:0046777 | protein autophosphorylation | 17077180 |
Tgene | PKD2 | GO:0050852 | T cell receptor signaling pathway | 17077180 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-E9-A243-01A | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000305798 | ENST00000237596 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
5CDS-5UTR | ENST00000305798 | ENST00000508588 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
5CDS-intron | ENST00000305798 | ENST00000511337 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
5CDS-intron | ENST00000305798 | ENST00000502363 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
intron-3CDS | ENST00000505184 | ENST00000237596 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
intron-5UTR | ENST00000505184 | ENST00000508588 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
intron-intron | ENST00000505184 | ENST00000511337 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
intron-intron | ENST00000505184 | ENST00000502363 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
intron-3CDS | ENST00000509168 | ENST00000237596 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
intron-5UTR | ENST00000509168 | ENST00000508588 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
intron-intron | ENST00000509168 | ENST00000511337 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
intron-intron | ENST00000509168 | ENST00000502363 | TSPAN5 | chr4 | 99579297 | - | PKD2 | chr4 | 88973143 | + |
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FusionProtFeatures for TSPAN5_PKD2 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TSPAN5 | PKD2 |
Regulates ADAM10 maturation and trafficking to the cellsurface. Promotes ADAM10-mediated cleavage of CD44.{ECO:0000269|PubMed:26686862}. | Functions as a cation channel involved in fluid-flowmechanosensation by the primary cilium in renal epithelium(PubMed:18695040). Functions as outward-rectifying K(+) channel,but is also permeable to Ca(2+), and to a much lesser degree alsoto Na(+) (PubMed:11854751, PubMed:15692563, PubMed:27071085,PubMed:27991905). May contribute to the release of Ca(2+) storesfrom the endoplasmic reticulum (PubMed:11854751, PubMed:20881056).Together with TRPV4, forms mechano- and thermosensitive channelsin cilium (PubMed:18695040). PKD1 and PKD2 may function through acommon signaling pathway that is necessary to maintain the normal,differentiated state of renal tubule cells. Acts as a regulator ofcilium length, together with PKD1. The dynamic control of ciliumlength is essential in the regulation of mechanotransductivesignaling. The cilium length response creates a negative feedbackloop whereby fluid shear-mediated deflection of the primarycilium, which decreases intracellular cAMP, leads to ciliumshortening and thus decreases flow-induced signaling. Alsoinvolved in left-right axis specification via its role in sensingnodal flow; forms a complex with PKD1L1 in cilia to facilitateflow detection in left-right patterning. Detection of asymmetricnodal flow gives rise to a Ca(2+) signal that is required fornormal, asymmetric expression of genes involved in thespecification of body left-right laterality (By similarity).{ECO:0000250|UniProtKB:O35245, ECO:0000269|PubMed:11854751,ECO:0000269|PubMed:15692563, ECO:0000269|PubMed:16551655,ECO:0000269|PubMed:18695040, ECO:0000269|PubMed:20881056,ECO:0000269|PubMed:27991905, ECO:0000305}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 1_17 | 27 | 269 | Topological domain | Cytoplasmic |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 763_774 | 516 | 969 | Calcium binding | Ontology_term=ECO:0000244,ECO:0000255,ECO:0000269,ECO:0000269 |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 833_872 | 516 | 969 | Coiled coil | Ontology_term=ECO:0000269,ECO:0000305 |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 750_785 | 516 | 969 | Domain | EF-hand |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 632_646 | 516 | 969 | Intramembrane | Pore-forming |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 641_643 | 516 | 969 | Motif | Selectivity filter |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 803_822 | 516 | 969 | Region | Linker |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 527_552 | 516 | 969 | Topological domain | Extracellular |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 574_597 | 516 | 969 | Topological domain | Cytoplasmic |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 620_631 | 516 | 969 | Topological domain | Extracellular |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 647_654 | 516 | 969 | Topological domain | Extracellular |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 676_968 | 516 | 969 | Topological domain | Cytoplasmic |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 553_573 | 516 | 969 | Transmembrane | Helical%3B Name%3DS4 |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 598_619 | 516 | 969 | Transmembrane | Helical%3B Name%3D5 |
Tgene | >PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 655_675 | 516 | 969 | Transmembrane | Helical%3B Name%3DS6 |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 114_232 | 27 | 269 | Topological domain | Extracellular |
Hgene | >TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 254_268 | 27 | 269 | Topological domain | Cytoplasmic |
Hgene | >TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 39_61 | 27 | 269 | Topological domain | Extracellular |
Hgene | >TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 83_92 | 27 | 269 | Topological domain | Cytoplasmic |
Hgene | >TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 18_38 | 27 | 269 | Transmembrane | Helical |
Hgene | >TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 233_253 | 27 | 269 | Transmembrane | Helical |
Hgene | >TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 62_82 | 27 | 269 | Transmembrane | Helical |
Hgene | >TSPAN5 | chr4:99579297 | chr4:88973143 | ENST00000305798 | - | 1 | 8 | 93_113 | 27 | 269 | Transmembrane | Helical |
Tgene | PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 153_157 | 516 | 969 | Compositional bias | Note=Poly-Arg |
Tgene | PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 95_107 | 516 | 969 | Compositional bias | Note=Poly-Glu |
Tgene | PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 1_219 | 516 | 969 | Topological domain | Cytoplasmic |
Tgene | PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 242_468 | 516 | 969 | Topological domain | Extracellular |
Tgene | PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 490_505 | 516 | 969 | Topological domain | Cytoplasmic |
Tgene | PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 220_241 | 516 | 969 | Transmembrane | Helical%3B Name%3DS1 |
Tgene | PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 469_489 | 516 | 969 | Transmembrane | Helical%3B Name%3DS2 |
Tgene | PKD2 | chr4:99579297 | chr4:88973143 | ENST00000237596 | + | 5 | 15 | 506_526 | 516 | 969 | Transmembrane | Helical%3B Name%3DS3 |
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FusionGeneSequence for TSPAN5_PKD2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_PKD2_ENST00000237596_chr4_88973143_+_480aa MSGKHYKGPEVSCCIKYFIFGFNVIFWLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINF NRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMF FILLNMFLAIINDTYSEVKSDLAQQKAEMELSDLIRKGYHKALVKLKLKKNTVDDISESLRQGGGKLNFDELRQDLKGKGHTDAEIEAIF TKYDQDGDQELTEHEHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLDDSEEDDDEDSGHSSRRRGSISSGVSYEEFQVLVRRVDRM EHSIGSIVSKIDAVIVKLEIMERAKLKRREVLGRLLDGVAEDERLGRDSEIHREQMERLVREELERWESDDAASQISHGLGTPVGLNGQP |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_PKD2_ENST00000237596_chr4_88973143_+_1440nt ATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAAATACTTCATATTTGGCTTCAATGTCATATTTTGGCTGTCAGTG GTAGCTATAGGAATTAACATATACAGAACATCAAATGTGGAGGTGCTACTACAGTTTCTGGAAGATCAAAATACTTTCCCCAACTTTGAG CATCTGGCATATTGGCAGATACAGTTCAACAATATAGCTGCTGTCACAGTATTTTTTGTCTGGATTAAGCTCTTCAAATTCATCAATTTT AACAGGACCATGAGCCAGCTCTCGACAACCATGTCTCGATGTGCCAAAGACCTGTTTGGCTTTGCTATTATGTTCTTCATTATTTTCCTA GCGTATGCTCAGTTGGCATACCTTGTCTTTGGCACTCAGGTCGATGACTTCAGTACTTTCCAAGAGTGTATCTTCACTCAATTCCGTATC ATTTTGGGCGATATCAACTTTGCAGAGATTGAGGAAGCTAATCGAGTTTTGGGACCAATTTATTTCACTACATTTGTGTTCTTTATGTTC TTCATTCTTTTGAATATGTTTTTGGCTATCATCAATGATACTTACTCTGAAGTGAAATCTGACTTGGCACAGCAGAAAGCTGAAATGGAA CTCTCAGATCTTATCAGAAAGGGCTACCATAAAGCTTTGGTCAAACTAAAACTGAAAAAAAATACCGTGGATGACATTTCAGAGAGTCTG CGGCAAGGAGGAGGCAAGTTAAACTTTGACGAACTTCGACAAGATCTCAAAGGGAAGGGCCATACTGATGCAGAGATTGAGGCAATATTC ACAAAGTACGACCAAGATGGAGACCAAGAACTGACCGAACATGAACATCAGCAGATGAGAGACGACTTGGAGAAAGAGAGGGAGGACCTG GATTTGGATCACAGTTCTTTACCACGTCCCATGAGCAGCCGAAGTTTCCCTCGAAGCCTGGATGACTCTGAGGAGGATGACGATGAAGAT AGCGGACATAGCTCCAGAAGGAGGGGAAGCATTTCTAGTGGCGTTTCTTACGAAGAGTTTCAAGTCCTGGTGAGACGAGTGGACCGGATG GAGCATTCCATCGGCAGCATAGTGTCCAAGATTGACGCCGTGATCGTGAAGCTAGAGATTATGGAGCGAGCCAAACTGAAGAGGAGGGAG GTGCTGGGAAGGCTGTTGGATGGGGTGGCCGAGGATGAAAGGCTGGGTCGTGACAGTGAAATCCATAGGGAACAGATGGAACGGCTAGTA CGTGAAGAGTTGGAACGCTGGGAATCCGATGATGCAGCTTCCCAGATCAGTCATGGTTTAGGCACGCCAGTGGGACTAAATGGTCAACCT CGCCCCAGAAGCTCCCGCCCATCTTCCTCCCAATCTACAGAAGGCATGGAAGGTGCAGGTGGAAATGGGAGTTCTAATGTCCACGTATGA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_TSPAN5_ENST00000305798_chr4_99579297_-_PKD2_ENST00000237596_chr4_88973143_+_3926nt GCGAACGGGCGGGCGAGCAAGCGAGCGGCGTCTCCACCAGCATCTGCCGCGGCCGCCTTTGCCCGAAGCCCGGGGACGAACCGACGGACC GACCGCCTGGCGCACGGACGCGGGCGCTCGCTTTGTGTTCGGGGCTAGCGTCGGCGAGGCTTGAGCTTGCAGCGCGCGGCTTCCCTGCTT TCTCGCGGCCACCCCGGCTCCGGCGGCCTCGGCGCGCGAGGGGCTGGAGGTGCGGGAGCCGCTCTCCGCCGGTCGGTCCCCGCGCGGCTG AGCCCAGGCCGCCAGCGCCGCGGCCCCGTGCGGTGTCCCTGAGCTCCTGCTCCCCGCCGGGCTGCTCCGAGCAACGGTGCTTCGGAGCTC CAAACTCGGGCTGCCGGGGCAAGTGTCTTCATGAACCCAGAGGATGTCCGGGAAGCACTACAAGGGTCCTGAAGTCAGTTGTTGCATCAA ATACTTCATATTTGGCTTCAATGTCATATTTTGGCTGTCAGTGGTAGCTATAGGAATTAACATATACAGAACATCAAATGTGGAGGTGCT ACTACAGTTTCTGGAAGATCAAAATACTTTCCCCAACTTTGAGCATCTGGCATATTGGCAGATACAGTTCAACAATATAGCTGCTGTCAC AGTATTTTTTGTCTGGATTAAGCTCTTCAAATTCATCAATTTTAACAGGACCATGAGCCAGCTCTCGACAACCATGTCTCGATGTGCCAA AGACCTGTTTGGCTTTGCTATTATGTTCTTCATTATTTTCCTAGCGTATGCTCAGTTGGCATACCTTGTCTTTGGCACTCAGGTCGATGA CTTCAGTACTTTCCAAGAGTGTATCTTCACTCAATTCCGTATCATTTTGGGCGATATCAACTTTGCAGAGATTGAGGAAGCTAATCGAGT TTTGGGACCAATTTATTTCACTACATTTGTGTTCTTTATGTTCTTCATTCTTTTGAATATGTTTTTGGCTATCATCAATGATACTTACTC TGAAGTGAAATCTGACTTGGCACAGCAGAAAGCTGAAATGGAACTCTCAGATCTTATCAGAAAGGGCTACCATAAAGCTTTGGTCAAACT AAAACTGAAAAAAAATACCGTGGATGACATTTCAGAGAGTCTGCGGCAAGGAGGAGGCAAGTTAAACTTTGACGAACTTCGACAAGATCT CAAAGGGAAGGGCCATACTGATGCAGAGATTGAGGCAATATTCACAAAGTACGACCAAGATGGAGACCAAGAACTGACCGAACATGAACA TCAGCAGATGAGAGACGACTTGGAGAAAGAGAGGGAGGACCTGGATTTGGATCACAGTTCTTTACCACGTCCCATGAGCAGCCGAAGTTT CCCTCGAAGCCTGGATGACTCTGAGGAGGATGACGATGAAGATAGCGGACATAGCTCCAGAAGGAGGGGAAGCATTTCTAGTGGCGTTTC TTACGAAGAGTTTCAAGTCCTGGTGAGACGAGTGGACCGGATGGAGCATTCCATCGGCAGCATAGTGTCCAAGATTGACGCCGTGATCGT GAAGCTAGAGATTATGGAGCGAGCCAAACTGAAGAGGAGGGAGGTGCTGGGAAGGCTGTTGGATGGGGTGGCCGAGGATGAAAGGCTGGG TCGTGACAGTGAAATCCATAGGGAACAGATGGAACGGCTAGTACGTGAAGAGTTGGAACGCTGGGAATCCGATGATGCAGCTTCCCAGAT CAGTCATGGTTTAGGCACGCCAGTGGGACTAAATGGTCAACCTCGCCCCAGAAGCTCCCGCCCATCTTCCTCCCAATCTACAGAAGGCAT GGAAGGTGCAGGTGGAAATGGGAGTTCTAATGTCCACGTATGATATGTGTGTTTCAGTATGTGTGTTTCTAATAAGTGAGGAAGTGGCTG TCCTGAATTGCTGTAACAAGCACACTATTTATATGCCCTGACCACCATAGGATGCTAGTCTTTGTGACCGATTGCTAATCTTCTGCACTT TAATTTATTTTATATAAACTTTACCCATGGTTCAAAGATTTTTTTTTCTTTTTCTCATATAAGAAATCTAGGTGTAAATATTGAGTACAG AAAAAAAATCTTCATGATGTGTATTGAGCGGTACGCCCAGTTGCCACCATGACTGAGTCTTCTCAGTTGACAATGAAGTAGCCTTTTAAA GCTAGAAAACTGTCAAAGGGCTTCTGAGTTTCATTTCCAGTCACAAAAATCAGTATTGTTATTTTTTTCCAAGAGTGTGAAGGAAAATGG GGCATTCCTTTCCACTCTGGCATAGTTCATGAGCTTAATACATAGCTTTCTTTTAAGAAAGGAGCCTTTTTTTTCAACTAGCTTCCTGGG GTAAACTTTTCTAAAAGATAAAATGGAAAGGAACTCCAAACTATGATAGAATCTGTGTGAATGGTTAAGATGAATGTTAAATACTATGCT TTTTTGTAAGTTGATCGTATCTGATGTCTGTGGGACTAACTGTATCACTTAATTTTTACCTTATTTTGGCTCTAATTTGAATAAGCTGAG TAAAACCACCAAAGATCAGTTATAGGATAAAATGGCATCTCTAACCATAACACAGGAGAATTGGAAGGAGCCCTAAGTTGTCACTCAGTT TAATTTCTTTTAATGGTTAGTTTAGCCTAAAGATTTATCTGCATATTCTTTTTCCCATGTGGCTCTACTCATTTGCAACTGAATTTAATG TTATAACTCATCTAGTGAGACCAACTTACTAAATTTTTAGTATGCACTGAAAGTTTTTATCCAACAATTATGTTCATTTTAAGCAAAATT TTAAGAAAGTTTTGAAATTCATAAAGCATTTGGTTTTAAACTATTTTAAGAATATAGTACTCGGTCAGGTATGACGGCTCACGCCTGTAA TCCCAGCACTTTGGGAGGCCGAAACAGGCGAATCACTTGAGCCCAGGAGTTCAAGACCAACATGGGCAATGTGGCGAAACTCCATCTCTA CAAAAAATGCAAAAATAAAAAATATAGTACTCAAGTATTCTTGATCCTGTGTTTCAAAACTAGAATTTGTAATGCAAATGGAGCTCAGTC TAATAAAAAAGAGGTTTTGGTATTAAAAGTTCATACATTAGACAGTATCAGCCAAAATTTGAGTTAGCAACACTGTTTTCTTTACGAGAG GGTCTCACCCAAATTTATGGGGAGAAATCTATTTCTCAAAAAAAAAAATCTTCTTTTACAGAAATGTTGAGTAAGGTGACATTTTGAGCG CTAATAAGCAAAAGAGCATGCAGTGCTGTTGAATAACCCTCACTTGGAGAACCAAGAGAATCCTGTCGTTTAATGCTATATTTTAATTTC ACAAGTTGTTCATTTAACTGGTAGAATGTCAGTCCAATCTCCAATGAGAACATGAGCAAATAGACCTTTCCAGGTTGAAAGTGAAACATA CTGGGTTTCTGTAAGTTTTTCCTCATGGCTTCATCTCTATCTTTACTTTCTCTTGAATATGCTACACAAAGTTCTTTATTACTACATACT AAAGTTTGCATTCCAGGGATATTGACTGTACATATTTATGTATATGTACCATGTTGTTACATGTAAACAAACTTCAATTTGAAGTGCAGC TATTATGTGGTATCCATGTGTATCGACCATGTGCCATATATCAATTATGGTCACTAGAAAGTCTCTTTATGATACTTTTTATTGTACTGT TTTTCATTTCACTTGCAAAATTTTGCAGAATTCCTCCTTTCTACCCATAAATTACATATATTTTTCTTCTTTAGTCATGGAGAACTCCCC CCCTCATCTCTTCCCTATTATCTTTCCCTGTGTACTGGTATTATTAAAAAGACATTACATACGCAAGTCTTTCTCGACAATCAAGAATGT |
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FusionGenePPI for TSPAN5_PKD2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TSPAN5 | APP, ADAM10, TMEM248, VKORC1L1, TMEM87A, ALG8, GDPD1, THAP11, AGPAT4, AGPAT3, SLC27A2, SPCS2, KLHL2, TMEM186, SOAT1, ATP2B3, RDH11, RFT1, GHDC, SLC7A2, TMUB1, SEC62, EFNB1, BSCL2, SC5D, GPR89A, LCLAT1, CD47, SNX25, ZDHHC9, LEMD2, ZDHHC6, IMMP1L, ALG11, NAT8L, TMEM192, RDH12, TMEM43, TMEM206, FTSJ2, NDC1, DAGLB, PSEN2, DNAJC19, TVP23C, WDR41, RDH14, B4GALT1, RER1, FAM210B, FAM134C, SPCS1, PIEZO1, SCAMP2, PRAF2, CYB5R3, NAT14, GP1BB, BRI3BP, ZDHHC21, SLC38A2, FAM213A, TRIM25 | PKD2 | PKD1, PKD2, TRPC1, TNNI3, CANX, GOLGA2, ATP1A1, MAGEA8, PLSCR1, KRT40, KRTAP10-8, KRTAP10-3, FAM3D, CEP170, ALG5, GLRA2, BCAS4, PICK1, SRPR, TMEM248, PKD2L2, PTGIR, CRYL1, CHRND, EXOC3, TPTE2, TMPRSS12, COG6, CNGA3, CD300E, GCC2, LMNA |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSPAN5_PKD2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSPAN5_PKD2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PKD2 | C2751306 | Polycystic kidney disease, type 2 | 6 | UNIPROT |
Tgene | PKD2 | C0085413 | Polycystic Kidney, Autosomal Dominant | 4 | CTD_human |
Tgene | PKD2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | PKD2 | C0035309 | Retinal Diseases | 1 | CTD_human |
Tgene | PKD2 | C0042373 | Vascular Diseases | 1 | CTD_human |
Tgene | PKD2 | C0524851 | Neurodegenerative Disorders | 1 | CTD_human |