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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39851

FusionGeneSummary for TSPAN3_FLRT2

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN3_FLRT2
Fusion gene ID: 39851
HgeneTgene
Gene symbol

TSPAN3

FLRT2

Gene ID

10099

23768

Gene nametetraspanin 3fibronectin leucine rich transmembrane protein 2
SynonymsTM4-A|TM4SF8|TSPAN-3-
Cytomap

15q24.3

14q31.3

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-3tetraspan 3tetraspan TM4SFtetraspanin TM4-Atransmembrane 4 superfamily member 8leucine-rich repeat transmembrane protein FLRT2fibronectin-like domain-containing leucine-rich transmembrane protein 2
Modification date2018052320180522
UniProtAcc

O60637

O43155

Ensembl transtripts involved in fusion geneENST00000267970, ENST00000346495, 
ENST00000424443, ENST00000561277, 
ENST00000559494, ENST00000558745, 
ENST00000558394, 		ENST00000330753, 
ENST00000557419, ENST00000554746, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 2 X 1=4
# samples 62
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context

PubMed: TSPAN3 [Title/Abstract] AND FLRT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK095520TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000267970ENST00000330753TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000267970ENST00000557419TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000267970ENST00000554746TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-3UTRENST00000346495ENST00000330753TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000346495ENST00000557419TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000346495ENST00000554746TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-3UTRENST00000424443ENST00000330753TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000424443ENST00000557419TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000424443ENST00000554746TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-3UTRENST00000561277ENST00000330753TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000561277ENST00000557419TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000561277ENST00000554746TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-3UTRENST00000559494ENST00000330753TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000559494ENST00000557419TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000559494ENST00000554746TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-3UTRENST00000558745ENST00000330753TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000558745ENST00000557419TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000558745ENST00000554746TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-3UTRENST00000558394ENST00000330753TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000558394ENST00000557419TSPAN3chr15

77338661

-FLRT2chr14

86093150

+
intron-intronENST00000558394ENST00000554746TSPAN3chr15

77338661

-FLRT2chr14

86093150

+

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FusionProtFeatures for TSPAN3_FLRT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN3

O60637

FLRT2

O43155

Regulates the proliferation and migration ofoligodendrocytes, a process essential for normal myelination andrepair. {ECO:0000250}. Functions in cell-cell adhesion, cell migration and axonguidance. Mediates cell-cell adhesion via its interactions withADGRL3 and probably also other latrophilins that are expressed atthe surface of adjacent cells. May play a role in the migration ofcortical neurons during brain development via its interaction withUNC5D. Mediates axon growth cone collapse and plays a repulsiverole in neuron guidance via its interaction with UNC5D, andpossibly also other UNC-5 family members. Plays a role infibroblast growth factor-mediated signaling cascades. Required fornormal organization of the cardiac basement membrane duringembryogenesis, and for normal embryonic epicardium and heartmorphogenesis. {ECO:0000250|UniProtKB:Q8BLU0}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSPAN3_FLRT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSPAN3_FLRT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSPAN3_FLRT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSPAN3_FLRT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource