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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39835

FusionGeneSummary for TSPAN1_TFF3

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN1_TFF3
Fusion gene ID: 39835
HgeneTgene
Gene symbol

TSPAN1

TFF3

Gene ID

10103

7033

Gene nametetraspanin 1trefoil factor 3
SynonymsNET1|TM4C|TM4SFITF|P1B|TFI
Cytomap

1p34.1

21q22.3

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-1tetraspan 1trefoil factor 3polypeptide P1.Btrefoil factor 3 (intestinal)
Modification date2018052320180527
UniProtAcc

O60635

Q07654

Ensembl transtripts involved in fusion geneENST00000498443, ENST00000372003, 
ENST00000291525, ENST00000518498, 
ENST00000489676, 
Fusion gene scores* DoF score4 X 1 X 3=122 X 2 X 2=8
# samples 42
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: TSPAN1 [Title/Abstract] AND TFF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTSPAN1

GO:0008283

cell proliferation

22378020

HgeneTSPAN1

GO:0050821

protein stabilization

21836059


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7738-01ATSPAN1chr1

46651630

+TFF3chr21

43735706

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000498443ENST00000291525TSPAN1chr1

46651630

+TFF3chr21

43735706

-
intron-5UTRENST00000498443ENST00000518498TSPAN1chr1

46651630

+TFF3chr21

43735706

-
intron-intronENST00000498443ENST00000489676TSPAN1chr1

46651630

+TFF3chr21

43735706

-
Frame-shiftENST00000372003ENST00000291525TSPAN1chr1

46651630

+TFF3chr21

43735706

-
5CDS-5UTRENST00000372003ENST00000518498TSPAN1chr1

46651630

+TFF3chr21

43735706

-
5CDS-intronENST00000372003ENST00000489676TSPAN1chr1

46651630

+TFF3chr21

43735706

-

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FusionProtFeatures for TSPAN1_TFF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN1

O60635

TFF3

Q07654

Involved in the maintenance and repair of the intestinalmucosa. Promotes the mobility of epithelial cells in healingprocesses (motogen). {ECO:0000269|PubMed:11694446}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSPAN1_TFF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSPAN1_TFF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TSPAN1NFKBIBTFF3TCF3, PCBD1, SGTA, ZSCAN9, AKR1C1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSPAN1_TFF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSPAN1_TFF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTFF3C0019188Hepatitis, Animal1CTD_human
TgeneTFF3C0022658Kidney Diseases1CTD_human
TgeneTFF3C0333355Inflammatory disease of mucous membrane1CTD_human
TgeneTFF3C2609414Acute kidney injury1CTD_human