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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39817

FusionGeneSummary for TSPAN14_TSPAN14

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN14_TSPAN14
Fusion gene ID: 39817
HgeneTgene
Gene symbol

TSPAN14

TSPAN14

Gene ID

81619

81619

Gene nametetraspanin 14tetraspanin 14
SynonymsDC-TM4F2|TM4SF14DC-TM4F2|TM4SF14
Cytomap

10q23.1

10q23.1

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-14tetraspanin similar to TM4SF9transmembrane 4 superfamily member 14tspan-14tetraspanin-14tetraspanin similar to TM4SF9transmembrane 4 superfamily member 14tspan-14
Modification date2018052320180523
UniProtAcc

Q8NG11

Q8NG11

Ensembl transtripts involved in fusion geneENST00000429989, ENST00000481124, 
ENST00000372164, ENST00000372158, 
ENST00000341863, ENST00000372156, 
ENST00000265450, 		ENST00000429989, 
ENST00000481124, ENST00000372164, 
ENST00000372158, ENST00000341863, 
ENST00000372156, ENST00000265450, 
Fusion gene scores* DoF score8 X 6 X 5=2407 X 8 X 2=112
# samples 98
** MAII scorelog2(9/240*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/112*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSPAN14 [Title/Abstract] AND TSPAN14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA343945TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
ChiTaRS3.1BF754904TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000429989ENST00000429989TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000429989ENST00000481124TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000429989ENST00000372164TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000429989ENST00000372158TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000429989ENST00000341863TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000429989ENST00000372156TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000429989ENST00000265450TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000481124ENST00000429989TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000481124ENST00000481124TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000481124ENST00000372164TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000481124ENST00000372158TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000481124ENST00000341863TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000481124ENST00000372156TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000481124ENST00000265450TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000372164ENST00000429989TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000372164ENST00000481124TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000372164ENST00000372164TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000372164ENST00000372158TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000372164ENST00000341863TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000372164ENST00000372156TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000372164ENST00000265450TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000372158ENST00000429989TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000372158ENST00000481124TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000372158ENST00000372164TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000372158ENST00000372158TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000372158ENST00000341863TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000372158ENST00000372156TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000372158ENST00000265450TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000341863ENST00000429989TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000341863ENST00000481124TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000341863ENST00000372164TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000341863ENST00000372158TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000341863ENST00000341863TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000341863ENST00000372156TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000341863ENST00000265450TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000372156ENST00000429989TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000372156ENST00000481124TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000372156ENST00000372164TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000372156ENST00000372158TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000372156ENST00000341863TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-intronENST00000372156ENST00000372156TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
intron-3UTRENST00000372156ENST00000265450TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000265450ENST00000429989TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000265450ENST00000481124TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000265450ENST00000372164TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000265450ENST00000372158TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000265450ENST00000341863TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-intronENST00000265450ENST00000372156TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000265450ENST00000265450TSPAN14chr10

82278647

+TSPAN14chr10

82278428

+
3UTR-3UTRENST00000429989ENST00000429989TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000429989ENST00000481124TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-3UTRENST00000429989ENST00000372164TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000429989ENST00000372158TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000429989ENST00000341863TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000429989ENST00000372156TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000429989ENST00000265450TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000481124ENST00000429989TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000481124ENST00000481124TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000481124ENST00000372164TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000481124ENST00000372158TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000481124ENST00000341863TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000481124ENST00000372156TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000481124ENST00000265450TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-3UTRENST00000372164ENST00000429989TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000372164ENST00000481124TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-3UTRENST00000372164ENST00000372164TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000372164ENST00000372158TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000372164ENST00000341863TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000372164ENST00000372156TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
3UTR-intronENST00000372164ENST00000265450TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000372158ENST00000429989TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372158ENST00000481124TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000372158ENST00000372164TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372158ENST00000372158TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372158ENST00000341863TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372158ENST00000372156TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372158ENST00000265450TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000341863ENST00000429989TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000341863ENST00000481124TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000341863ENST00000372164TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000341863ENST00000372158TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000341863ENST00000341863TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000341863ENST00000372156TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000341863ENST00000265450TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000372156ENST00000429989TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372156ENST00000481124TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000372156ENST00000372164TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372156ENST00000372158TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372156ENST00000341863TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372156ENST00000372156TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000372156ENST00000265450TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000265450ENST00000429989TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000265450ENST00000481124TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-3UTRENST00000265450ENST00000372164TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000265450ENST00000372158TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000265450ENST00000341863TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000265450ENST00000372156TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-
intron-intronENST00000265450ENST00000265450TSPAN14chr10

82280276

-TSPAN14chr10

82280987

-

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FusionProtFeatures for TSPAN14_TSPAN14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN14

Q8NG11

TSPAN14

Q8NG11

Regulates maturation and trafficking of thetransmembrane metalloprotease ADAM10 (PubMed:26668317,PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediatedcleavage of CDH5 (By similarity). {ECO:0000250|UniProtKB:Q8QZY6,ECO:0000269|PubMed:23035126, ECO:0000269|PubMed:26668317,ECO:0000269|PubMed:26686862}. Regulates maturation and trafficking of thetransmembrane metalloprotease ADAM10 (PubMed:26668317,PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediatedcleavage of CDH5 (By similarity). {ECO:0000250|UniProtKB:Q8QZY6,ECO:0000269|PubMed:23035126, ECO:0000269|PubMed:26668317,ECO:0000269|PubMed:26686862}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSPAN14_TSPAN14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSPAN14_TSPAN14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSPAN14_TSPAN14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSPAN14_TSPAN14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource