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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39806

FusionGeneSummary for TSPAN10_PCYT2

check button Fusion gene summary
Fusion gene informationFusion gene name: TSPAN10_PCYT2
Fusion gene ID: 39806
HgeneTgene
Gene symbol

TSPAN10

PCYT2

Gene ID

83882

5833

Gene nametetraspanin 10phosphate cytidylyltransferase 2, ethanolamine
SynonymsOCSPET
Cytomap

17q25.3

17q25.3

Type of geneprotein-codingprotein-coding
Descriptiontetraspanin-10oculospanintspan-10ethanolamine-phosphate cytidylyltransferaseCTP:phosphoethanolamine cytidylyltransferasephosphorylethanolamine transferase
Modification date2018052320180519
UniProtAcc

Q9H1Z9

Q99447

Ensembl transtripts involved in fusion geneENST00000571914, ENST00000328585, 
ENST00000572675, 
ENST00000538936, 
ENST00000331285, ENST00000538721, 
ENST00000571105, ENST00000570391, 
ENST00000570388, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 2 X 2=12
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TSPAN10 [Title/Abstract] AND PCYT2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTSPAN10

GO:0072594

establishment of protein localization to organelle

23091066


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-A2-A0T1-01ATSPAN10chr17

79604294

+PCYT2chr17

79860770

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000571914ENST00000538936TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
3UTR-intronENST00000571914ENST00000331285TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
3UTR-intronENST00000571914ENST00000538721TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
3UTR-intronENST00000571914ENST00000571105TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
3UTR-intronENST00000571914ENST00000570391TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
3UTR-intronENST00000571914ENST00000570388TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-3UTRENST00000328585ENST00000538936TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000328585ENST00000331285TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000328585ENST00000538721TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000328585ENST00000571105TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000328585ENST00000570391TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000328585ENST00000570388TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-3UTRENST00000572675ENST00000538936TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000572675ENST00000331285TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000572675ENST00000538721TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000572675ENST00000571105TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000572675ENST00000570391TSPAN10chr17

79604294

+PCYT2chr17

79860770

-
intron-intronENST00000572675ENST00000570388TSPAN10chr17

79604294

+PCYT2chr17

79860770

-

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FusionProtFeatures for TSPAN10_PCYT2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSPAN10

Q9H1Z9

PCYT2

Q99447

Regulates maturation of the transmembranemetalloprotease ADAM10. {ECO:0000250|UniProtKB:Q8VCF5}. Plays an important role in the biosynthesis of thephospholipid phosphatidylethanolamine. Catalyzes the formation ofCDP-ethanolamine.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSPAN10_PCYT2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSPAN10_PCYT2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TSPAN10ADAM10, HSD17B13, GPR114, PNLDC1PCYT2KDM8, ADAMTS10, CRIP2, SETDB1, DNMT3B, GDF9, CAPN2, DCPS, CAMK1D, EIF5, NAE1, PDHB, RAB1A, UBA3, XPO1, YWHAH, PARK2, INPPL1, COASY


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSPAN10_PCYT2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSPAN10_PCYT2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource