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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39798

FusionGeneSummary for TSNARE1_RIF1

check button Fusion gene summary
Fusion gene informationFusion gene name: TSNARE1_RIF1
Fusion gene ID: 39798
HgeneTgene
Gene symbol

TSNARE1

RIF1

Gene ID

203062

55791

Gene namet-SNARE domain containing 1ligand dependent nuclear receptor interacting factor 1
Synonyms-C1orf103|RIF1
Cytomap

8q24.3

1p13.3

Type of geneprotein-codingprotein-coding
Descriptiont-SNARE domain-containing protein 1ligand-dependent nuclear receptor-interacting factor 1receptor-interacting factor 1
Modification date2018052320180523
UniProtAcc

Q96NA8

Q5UIP0

Ensembl transtripts involved in fusion geneENST00000524325, ENST00000307180, 
ENST00000520166, ENST00000519651, 
ENST00000518928, 
ENST00000444746, 
ENST00000453091, ENST00000428287, 
ENST00000243326, ENST00000430328, 
ENST00000433166, ENST00000457745, 
Fusion gene scores* DoF score6 X 5 X 3=903 X 3 X 2=18
# samples 64
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: TSNARE1 [Title/Abstract] AND RIF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1U25770TSNARE1chr8

143351500

+RIF1chr2

152333352

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000524325ENST00000444746TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000524325ENST00000453091TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000524325ENST00000428287TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-3UTRENST00000524325ENST00000243326TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000524325ENST00000430328TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000524325ENST00000433166TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000524325ENST00000457745TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000307180ENST00000444746TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000307180ENST00000453091TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000307180ENST00000428287TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-3UTRENST00000307180ENST00000243326TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000307180ENST00000430328TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000307180ENST00000433166TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000307180ENST00000457745TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000520166ENST00000444746TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000520166ENST00000453091TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000520166ENST00000428287TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-3UTRENST00000520166ENST00000243326TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000520166ENST00000430328TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000520166ENST00000433166TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000520166ENST00000457745TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000519651ENST00000444746TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000519651ENST00000453091TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000519651ENST00000428287TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-3UTRENST00000519651ENST00000243326TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000519651ENST00000430328TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000519651ENST00000433166TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000519651ENST00000457745TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000518928ENST00000444746TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000518928ENST00000453091TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000518928ENST00000428287TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-3UTRENST00000518928ENST00000243326TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000518928ENST00000430328TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000518928ENST00000433166TSNARE1chr8

143351500

+RIF1chr2

152333352

+
intron-intronENST00000518928ENST00000457745TSNARE1chr8

143351500

+RIF1chr2

152333352

+

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FusionProtFeatures for TSNARE1_RIF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSNARE1

Q96NA8

RIF1

Q5UIP0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSNARE1_RIF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSNARE1_RIF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSNARE1_RIF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSNARE1_RIF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTSNARE1C0036341Schizophrenia1PSYGENET