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Fusion gene ID: 39790 |
FusionGeneSummary for TSKU_KDM5A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSKU_KDM5A | Fusion gene ID: 39790 | Hgene | Tgene | Gene symbol | TSKU | KDM5A | Gene ID | 25987 | 5927 |
| Gene name | tsukushi, small leucine rich proteoglycan | lysine demethylase 5A | |
| Synonyms | E2IG4|LRRC54|TSK | RBBP-2|RBBP2|RBP2 | |
| Cytomap | 11q13.5 | 12p13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tsukushinE2-induced gene 4 proteinleucine rich repeat containing 54leucine-rich repeat-containing protein 54tsukushi homologtsukushi small leucine rich proteoglycan homolog | lysine-specific demethylase 5AJumonji, AT rich interactive domain 1A (RBP2-like)histone demethylase JARID1Ajumonji/ARID domain-containing protein 1Alysine (K)-specific demethylase 5Aretinoblastoma binding protein 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8WUA8 | P29375 | |
| Ensembl transtripts involved in fusion gene | ENST00000333090, ENST00000527881, | ENST00000399788, ENST00000540838, ENST00000382815, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 5 X 5 X 2=50 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TSKU [Title/Abstract] AND KDM5A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | KDM5A | GO:0033169 | histone H3-K9 demethylation | 18270511 |
| Tgene | KDM5A | GO:0034720 | histone H3-K4 demethylation | 18270511 |
| Tgene | KDM5A | GO:0045893 | positive regulation of transcription, DNA-templated | 11358960 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA455152 | TSKU | chr11 | 76506776 | + | KDM5A | chr12 | 495134 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000333090 | ENST00000399788 | TSKU | chr11 | 76506776 | + | KDM5A | chr12 | 495134 | - |
| 5CDS-intron | ENST00000333090 | ENST00000540838 | TSKU | chr11 | 76506776 | + | KDM5A | chr12 | 495134 | - |
| 5CDS-intron | ENST00000333090 | ENST00000382815 | TSKU | chr11 | 76506776 | + | KDM5A | chr12 | 495134 | - |
| Frame-shift | ENST00000527881 | ENST00000399788 | TSKU | chr11 | 76506776 | + | KDM5A | chr12 | 495134 | - |
| 5CDS-intron | ENST00000527881 | ENST00000540838 | TSKU | chr11 | 76506776 | + | KDM5A | chr12 | 495134 | - |
| 5CDS-intron | ENST00000527881 | ENST00000382815 | TSKU | chr11 | 76506776 | + | KDM5A | chr12 | 495134 | - |
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FusionProtFeatures for TSKU_KDM5A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSKU | KDM5A |
| Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code.Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36',H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated anddimethylated but not monomethylated H3 'Lys-4'. Regulates specificgene transcription through DNA-binding on 5'-CCGCCC-3' motif(PubMed:18270511). May stimulate transcription mediated by nuclearreceptors. Involved in transcriptional regulation of Hox proteinsduring cell differentiation (PubMed:19430464). May participate intranscriptional repression of cytokines such as CXCL12. Plays arole in the regulation of the circadian rhythm and in maintainingthe normal periodicity of the circadian clock. In a histonedemethylase-independent manner, acts as a coactivator of theCLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2and other clock-controlled genes and increases histone acetylationat PER1/2 promoters by inhibiting the activity of HDAC1 (Bysimilarity). Seems to act as a transcriptional corepressor forsome genes such as MT1F and to favor the proliferation of cancercells (PubMed:27427228). {ECO:0000250|UniProtKB:Q3UXZ9,ECO:0000269|PubMed:11358960, ECO:0000269|PubMed:15949438,ECO:0000269|PubMed:17320160, ECO:0000269|PubMed:17320161,ECO:0000269|PubMed:17320163, ECO:0000269|PubMed:18270511,ECO:0000269|PubMed:19430464, ECO:0000269|PubMed:27427228}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSKU_KDM5A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TSKU_ENST00000333090_chr11_76506776_+_KDM5A_ENST00000399788_chr12_495134_-_1636aa DWQPPFACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKVGSR LGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTE LKKLQIFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIP PLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISS KDFGSGFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYG VPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIG RQCVNHYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSACRTTCFL SALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKY PENDLFRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMM DETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERW EEKAKVCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVES QVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDIGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVAVFKEREQ KEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQKKGSSWQAKEVKFLCPLCMRSRRPRLET ILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPS FQQSAFNRVVSSVSSSPRQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAEHAYSSA SKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQLEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLK VKGKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLKLGADKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKESTEKKRE KKVLDIPSKYDWSGAEESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVSPEMAENEDYICINCAKKQGPVSPGPAPPPSF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TSKU_ENST00000333090_chr11_76506776_+_KDM5A_ENST00000399788_chr12_495134_-_4908nt GACTGGCAGCCTCCATTTGCCTGTGAAGTAAAAAGCTTTCGTTTCACTCCAAGAGTCCAGCGCCTGAATGAACTTGAGGCAATGACCAGA GTGAGATTGGATTTCTTGGATCAACTAGCAAAATTTTGGGAACTTCAAGGATCTACTCTGAAGATCCCTGTGGTAGAGAGAAAAATCCTG GATCTGTATGCTTTGAGCAAGATTGTTGCCAGCAAAGGAGGTTTTGAAATGGTCACCAAAGAGAAGAAATGGTCTAAAGTGGGTAGTCGC TTGGGATATCTGCCAGGAAAAGGAACTGGGTCTCTTTTGAAGTCACATTATGAAAGAATTCTCTACCCATATGAGCTTTTCCAGTCTGGT GTGAGCCTTATGGGTGTGCAGATGCCTAATTTAGATCTTAAAGAAAAAGTGGAGCCTGAGGTTCTCAGCACTGATACCCAAACTTCCCCA GAGCCAGGCACAAGGATGAACATTCTGCCGAAGAGAACAAGACGTGTGAAGACTCAGTCAGAATCTGGAGATGTGAGTAGAAACACGGAA CTGAAGAAACTTCAGATTTTTGGGGCTGGGCCCAAGGTTGTGGGCTTGGCAATGGGAACAAAAGATAAAGAAGATGAGGTCACCCGAAGA CGAAAAGTTACCAACAGGTCAGACGCATTTAACATGCAAATGAGACAACGGAAAGGCACTCTCTCTGTTAACTTTGTTGATCTCTATGTT TGTATGTTTTGTGGTCGGGGAAACAATGAAGATAAATTGCTTTTGTGTGATGGATGTGATGACAGCTATCATACATTTTGTCTAATTCCT CCACTACCTGATGTGCCCAAAGGAGACTGGAGGTGTCCTAAATGTGTCGCCGAGGAATGTAGCAAACCTCGAGAAGCCTTTGGATTTGAA CAAGCTGTACGAGAGTATACACTTCAGAGCTTTGGAGAGATGGCAGATAATTTTAAGTCTGATTATTTTAATATGCCAGTCCATATGGTT CCCACAGAACTAGTAGAAAAGGAATTTTGGCGGCTGGTAAGCAGCATTGAAGAAGATGTTATTGTGGAATATGGAGCAGATATCTCCTCA AAAGACTTTGGAAGTGGATTTCCGGTGAAGGATGGGCGGAGAAAGATTCTGCCAGAAGAAGAGGAATATGCACTTTCTGGTTGGAATTTG AATAACATGCCTGTCCTGGAACAGTCTGTTCTTGCACATATTAATGTGGACATCTCTGGTATGAAAGTGCCGTGGCTCTATGTGGGAATG TGCTTCTCTTCTTTTTGCTGGCACATTGAGGATCACTGGAGTTATTCCATCAACTACTTGCACTGGGGGGAGCCAAAGACATGGTATGGT GTGCCATCTCATGCTGCAGAGCAACTGGAGGAGGTGATGAGAGAGCTGGCCCCCGAGTTATTTGAATCCCAGCCTGATCTTCTGCATCAG TTAGTTACCATCATGAACCCCAACGTGCTAATGGAGCATGGTGTGCCTGTGTACAGGACCAATCAGTGTGCTGGCGAGTTTGTTGTGACA TTTCCTCGTGCCTATCACTCTGGATTTAACCAGGGCTACAACTTTGCTGAAGCTGTGAACTTCTGTACTGCTGACTGGTTGCCCATTGGA CGTCAATGTGTAAATCATTACCGACGCCTAAGGCGCCACTGTGTCTTTTCACACGAGGAACTAATTTTCAAGATGGCAGCAGATCCAGAA TGCTTAGATGTGGGGCTGGCTGCCATGGTCTGCAAAGAATTGACTCTCATGACTGAAGAAGAAACACGATTAAGAGAGTCTGTTGTACAG ATGGGTGTCCTGATGTCAGAAGAAGAAGTGTTTGAACTTGTTCCTGATGATGAGCGGCAGTGTTCAGCATGCAGAACCACATGTTTTCTC TCTGCTCTCACATGTTCCTGTAATCCTGAGCGGCTTGTATGTCTCTACCATCCAACTGATCTGTGCCCCTGCCCCATGCAGAAGAAATGT CTTAGATATCGCTACCCATTAGAAGACCTCCCTTCTCTGCTATATGGTGTAAAAGTCAGGGCACAGTCCTATGACACTTGGGTCAGTCGT GTTACAGAAGCATTGTCTGCTAACTTCAACCACAAAAAAGATTTGATTGAATTGCGAGTAATGCTGGAAGATGCTGAGGATAGGAAATAC CCAGAGAATGATCTCTTTCGAAAACTCAGGGATGCTGTAAAAGAAGCTGAGACCTGTGCTTCTGTGGCTCAGCTGCTTCTGAGCAAAAAG CAGAAACACAGACAGAGCCCAGATAGTGGGAGGACTCGGACCAAACTGACAGTGGAAGAATTGAAGGCCTTTGTCCAACAACTTTTTAGT CTTCCGTGTGTCATCAGCCAAGCTCGGCAAGTAAAGAATCTGCTAGATGATGTGGAAGAGTTTCATGAACGTGCTCAGGAGGCCATGATG GATGAAACCCCAGATTCTTCCAAACTCCAGATGTTGATAGATATGGGCTCTAGTCTCTATGTGGAACTCCCTGAATTACCACGACTGAAG CAAGAGCTACAACAGGCTCGGTGGTTGGACGAAGTAAGACTGACCTTATCAGATCCGCAACAAGTCACTTTGGATGTCATGAAGAAGCTG ATAGACTCTGGGGTAGGGTTGGCACCCCACCATGCTGTGGAGAAAGCAATGGCTGAACTACAGGAGCTCCTTACAGTCTCTGAACGATGG GAAGAAAAGGCTAAGGTCTGCCTACAGGCAAGACCGAGGCACAGTGTGGCAAGTTTAGAAAGCATTGTGAATGAAGCCAAGAACATTCCA GCCTTTCTACCCAATGTGTTGTCCTTGAAAGAAGCCTTACAAAAGGCTCGAGAATGGACCGCTAAAGTGGAAGCTATTCAGAGTGGCAGC AATTACGCTTATTTGGAGCAGCTTGAGAGCTTGTCTGCGAAAGGACGCCCTATTCCTGTGCGTCTTGAAGCACTGCCGCAAGTGGAATCA CAGGTAGCAGCAGCACGGGCATGGAGAGAACGGACTGGGCGGACGTTTCTTAAGAAGAATTCTAGCCATACATTGTTACAGGTGCTGAGC CCCCGGACCGACATTGGTGTATATGGGAGTGGCAAAAATAGGAGGAAAAAAGTAAAAGAACTAATAGAAAAAGAAAAAGAAAAGGATCTG GACCTGGAGCCTCTGAGTGATCTGGAGGAAGGATTGGAGGAAACCAGAGATACAGCCATGGTGGTGGCAGTTTTCAAAGAACGGGAGCAA AAAGAGATTGAAGCCATGCATTCTCTCAGAGCAGCCAACCTAGCCAAGATGACAATGGTGGACCGCATAGAAGAAGTAAAATTTTGCATT TGCCGCAAGACAGCCAGTGGGTTTATGCTACAGTGTGAGCTCTGCAAAGACTGGTTCCATAACAGCTGTGTTCCTCTTCCTAAATCAAGT TCCCAAAAAAAAGGATCCAGCTGGCAAGCTAAAGAAGTAAAATTCCTTTGCCCTCTTTGTATGCGGTCTCGAAGGCCCAGGCTAGAGACT ATTCTGTCACTCCTGGTATCCCTTCAGAAGTTGCCCGTACGGTTGCCTGAAGGAGAGGCCCTGCAGTGTTTGACAGAACGTGCTATGAGT TGGCAAGATAGAGCGCGGCAGGCTCTAGCCACAGATGAACTATCCTCTGCCCTGGCCAAACTATCTGTGTTGAGCCAGCGTATGGTGGAA CAGGCGGCTCGAGAAAAAACTGAAAAGATCATCAGTGCAGAACTCCAAAAAGCAGCTGCCAATCCAGACTTACAGGGACACTTACCTAGT TTCCAGCAGTCTGCTTTTAACCGGGTGGTGAGCAGTGTGTCATCTTCTCCTCGACAAACAATGGACTATGATGATGAAGAAACAGACTCT GATGAAGACATTCGAGAGACATATGGCTACGACATGAAGGACACAGCCAGTGTGAAGTCCTCTAGTAGTCTTGAACCCAATCTTTTTTGT GATGAAGAGATTCCCATCAAATCCGAGGAGGTGGTGACCCACATGTGGACAGCACCTTCATTTTGTGCAGAGCATGCTTATTCTTCTGCT TCTAAGAGTTGTTCTCAAGGTTCTAGCACCCCAAGGAAACAACCTCGGAAGAGCCCTTTGGTGCCCCGAAGTTTGGAACCTCCAGTGCTG GAGTTGTCACCTGGAGCTAAGGCACAACTGGAAGAACTTATGATGGTTGGAGATCTCCTGGAAGTATCTCTGGACGAGACTCAACACATA TGGCGGATTTTGCAGGCCACACACCCACCCTCTGAAGACAGATTCTTGCATATCATGGAGGATGACAGCATGGAAGAGAAACCACTAAAA GTGAAAGGAAAGGACTCTTCAGAGAAGAAACGGAAACGGAAGCTAGAAAAGGTAGAGCAACTTTTTGGAGAAGGAAAACAGAAGTCCAAG GAGTTAAAGAAAATGGACAAACCTAGAAAGAAGAAATTAAAATTAGGTGCAGACAAATCAAAGGAGCTGAATAAACTGGCCAAGAAACTA GCAAAAGAAGAAGAGAGAAAGAAAAAGAAGGAGAAGGCTGCTGCAGCCAAAGTTGAACTTGTGAAAGAGAGCACTGAAAAGAAAAGAGAG AAAAAGGTGCTGGACATCCCCTCAAAGTATGACTGGTCAGGAGCAGAGGAGTCTGATGATGAGAATGCTGTGTGCGCAGCACAGAACTGC CAAAGGCCCTGCAAGGACAAGGTAGACTGGGTACAATGTGATGGTGGCTGTGATGAGTGGTTTCATCAAGTTTGTGTGGGTGTATCTCCA GAAATGGCTGAAAATGAAGATTACATCTGTATAAACTGTGCAAAGAAGCAGGGGCCAGTTAGCCCAGGTCCAGCACCACCTCCTTCCTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TSKU_ENST00000333090_chr11_76506776_+_KDM5A_ENST00000399788_chr12_495134_-_10235nt GACTGGCAGCCTCCATTTGCCTGTGAAGTAAAAAGCTTTCGTTTCACTCCAAGAGTCCAGCGCCTGAATGAACTTGAGGCAATGACCAGA GTGAGATTGGATTTCTTGGATCAACTAGCAAAATTTTGGGAACTTCAAGGATCTACTCTGAAGATCCCTGTGGTAGAGAGAAAAATCCTG GATCTGTATGCTTTGAGCAAGATTGTTGCCAGCAAAGGAGGTTTTGAAATGGTCACCAAAGAGAAGAAATGGTCTAAAGTGGGTAGTCGC TTGGGATATCTGCCAGGAAAAGGAACTGGGTCTCTTTTGAAGTCACATTATGAAAGAATTCTCTACCCATATGAGCTTTTCCAGTCTGGT GTGAGCCTTATGGGTGTGCAGATGCCTAATTTAGATCTTAAAGAAAAAGTGGAGCCTGAGGTTCTCAGCACTGATACCCAAACTTCCCCA GAGCCAGGCACAAGGATGAACATTCTGCCGAAGAGAACAAGACGTGTGAAGACTCAGTCAGAATCTGGAGATGTGAGTAGAAACACGGAA CTGAAGAAACTTCAGATTTTTGGGGCTGGGCCCAAGGTTGTGGGCTTGGCAATGGGAACAAAAGATAAAGAAGATGAGGTCACCCGAAGA CGAAAAGTTACCAACAGGTCAGACGCATTTAACATGCAAATGAGACAACGGAAAGGCACTCTCTCTGTTAACTTTGTTGATCTCTATGTT TGTATGTTTTGTGGTCGGGGAAACAATGAAGATAAATTGCTTTTGTGTGATGGATGTGATGACAGCTATCATACATTTTGTCTAATTCCT CCACTACCTGATGTGCCCAAAGGAGACTGGAGGTGTCCTAAATGTGTCGCCGAGGAATGTAGCAAACCTCGAGAAGCCTTTGGATTTGAA CAAGCTGTACGAGAGTATACACTTCAGAGCTTTGGAGAGATGGCAGATAATTTTAAGTCTGATTATTTTAATATGCCAGTCCATATGGTT CCCACAGAACTAGTAGAAAAGGAATTTTGGCGGCTGGTAAGCAGCATTGAAGAAGATGTTATTGTGGAATATGGAGCAGATATCTCCTCA AAAGACTTTGGAAGTGGATTTCCGGTGAAGGATGGGCGGAGAAAGATTCTGCCAGAAGAAGAGGAATATGCACTTTCTGGTTGGAATTTG AATAACATGCCTGTCCTGGAACAGTCTGTTCTTGCACATATTAATGTGGACATCTCTGGTATGAAAGTGCCGTGGCTCTATGTGGGAATG TGCTTCTCTTCTTTTTGCTGGCACATTGAGGATCACTGGAGTTATTCCATCAACTACTTGCACTGGGGGGAGCCAAAGACATGGTATGGT GTGCCATCTCATGCTGCAGAGCAACTGGAGGAGGTGATGAGAGAGCTGGCCCCCGAGTTATTTGAATCCCAGCCTGATCTTCTGCATCAG TTAGTTACCATCATGAACCCCAACGTGCTAATGGAGCATGGTGTGCCTGTGTACAGGACCAATCAGTGTGCTGGCGAGTTTGTTGTGACA TTTCCTCGTGCCTATCACTCTGGATTTAACCAGGGCTACAACTTTGCTGAAGCTGTGAACTTCTGTACTGCTGACTGGTTGCCCATTGGA CGTCAATGTGTAAATCATTACCGACGCCTAAGGCGCCACTGTGTCTTTTCACACGAGGAACTAATTTTCAAGATGGCAGCAGATCCAGAA TGCTTAGATGTGGGGCTGGCTGCCATGGTCTGCAAAGAATTGACTCTCATGACTGAAGAAGAAACACGATTAAGAGAGTCTGTTGTACAG ATGGGTGTCCTGATGTCAGAAGAAGAAGTGTTTGAACTTGTTCCTGATGATGAGCGGCAGTGTTCAGCATGCAGAACCACATGTTTTCTC TCTGCTCTCACATGTTCCTGTAATCCTGAGCGGCTTGTATGTCTCTACCATCCAACTGATCTGTGCCCCTGCCCCATGCAGAAGAAATGT CTTAGATATCGCTACCCATTAGAAGACCTCCCTTCTCTGCTATATGGTGTAAAAGTCAGGGCACAGTCCTATGACACTTGGGTCAGTCGT GTTACAGAAGCATTGTCTGCTAACTTCAACCACAAAAAAGATTTGATTGAATTGCGAGTAATGCTGGAAGATGCTGAGGATAGGAAATAC CCAGAGAATGATCTCTTTCGAAAACTCAGGGATGCTGTAAAAGAAGCTGAGACCTGTGCTTCTGTGGCTCAGCTGCTTCTGAGCAAAAAG CAGAAACACAGACAGAGCCCAGATAGTGGGAGGACTCGGACCAAACTGACAGTGGAAGAATTGAAGGCCTTTGTCCAACAACTTTTTAGT CTTCCGTGTGTCATCAGCCAAGCTCGGCAAGTAAAGAATCTGCTAGATGATGTGGAAGAGTTTCATGAACGTGCTCAGGAGGCCATGATG GATGAAACCCCAGATTCTTCCAAACTCCAGATGTTGATAGATATGGGCTCTAGTCTCTATGTGGAACTCCCTGAATTACCACGACTGAAG CAAGAGCTACAACAGGCTCGGTGGTTGGACGAAGTAAGACTGACCTTATCAGATCCGCAACAAGTCACTTTGGATGTCATGAAGAAGCTG ATAGACTCTGGGGTAGGGTTGGCACCCCACCATGCTGTGGAGAAAGCAATGGCTGAACTACAGGAGCTCCTTACAGTCTCTGAACGATGG GAAGAAAAGGCTAAGGTCTGCCTACAGGCAAGACCGAGGCACAGTGTGGCAAGTTTAGAAAGCATTGTGAATGAAGCCAAGAACATTCCA GCCTTTCTACCCAATGTGTTGTCCTTGAAAGAAGCCTTACAAAAGGCTCGAGAATGGACCGCTAAAGTGGAAGCTATTCAGAGTGGCAGC AATTACGCTTATTTGGAGCAGCTTGAGAGCTTGTCTGCGAAAGGACGCCCTATTCCTGTGCGTCTTGAAGCACTGCCGCAAGTGGAATCA CAGGTAGCAGCAGCACGGGCATGGAGAGAACGGACTGGGCGGACGTTTCTTAAGAAGAATTCTAGCCATACATTGTTACAGGTGCTGAGC CCCCGGACCGACATTGGTGTATATGGGAGTGGCAAAAATAGGAGGAAAAAAGTAAAAGAACTAATAGAAAAAGAAAAAGAAAAGGATCTG GACCTGGAGCCTCTGAGTGATCTGGAGGAAGGATTGGAGGAAACCAGAGATACAGCCATGGTGGTGGCAGTTTTCAAAGAACGGGAGCAA AAAGAGATTGAAGCCATGCATTCTCTCAGAGCAGCCAACCTAGCCAAGATGACAATGGTGGACCGCATAGAAGAAGTAAAATTTTGCATT TGCCGCAAGACAGCCAGTGGGTTTATGCTACAGTGTGAGCTCTGCAAAGACTGGTTCCATAACAGCTGTGTTCCTCTTCCTAAATCAAGT TCCCAAAAAAAAGGATCCAGCTGGCAAGCTAAAGAAGTAAAATTCCTTTGCCCTCTTTGTATGCGGTCTCGAAGGCCCAGGCTAGAGACT ATTCTGTCACTCCTGGTATCCCTTCAGAAGTTGCCCGTACGGTTGCCTGAAGGAGAGGCCCTGCAGTGTTTGACAGAACGTGCTATGAGT TGGCAAGATAGAGCGCGGCAGGCTCTAGCCACAGATGAACTATCCTCTGCCCTGGCCAAACTATCTGTGTTGAGCCAGCGTATGGTGGAA CAGGCGGCTCGAGAAAAAACTGAAAAGATCATCAGTGCAGAACTCCAAAAAGCAGCTGCCAATCCAGACTTACAGGGACACTTACCTAGT TTCCAGCAGTCTGCTTTTAACCGGGTGGTGAGCAGTGTGTCATCTTCTCCTCGACAAACAATGGACTATGATGATGAAGAAACAGACTCT GATGAAGACATTCGAGAGACATATGGCTACGACATGAAGGACACAGCCAGTGTGAAGTCCTCTAGTAGTCTTGAACCCAATCTTTTTTGT GATGAAGAGATTCCCATCAAATCCGAGGAGGTGGTGACCCACATGTGGACAGCACCTTCATTTTGTGCAGAGCATGCTTATTCTTCTGCT TCTAAGAGTTGTTCTCAAGGTTCTAGCACCCCAAGGAAACAACCTCGGAAGAGCCCTTTGGTGCCCCGAAGTTTGGAACCTCCAGTGCTG GAGTTGTCACCTGGAGCTAAGGCACAACTGGAAGAACTTATGATGGTTGGAGATCTCCTGGAAGTATCTCTGGACGAGACTCAACACATA TGGCGGATTTTGCAGGCCACACACCCACCCTCTGAAGACAGATTCTTGCATATCATGGAGGATGACAGCATGGAAGAGAAACCACTAAAA GTGAAAGGAAAGGACTCTTCAGAGAAGAAACGGAAACGGAAGCTAGAAAAGGTAGAGCAACTTTTTGGAGAAGGAAAACAGAAGTCCAAG GAGTTAAAGAAAATGGACAAACCTAGAAAGAAGAAATTAAAATTAGGTGCAGACAAATCAAAGGAGCTGAATAAACTGGCCAAGAAACTA GCAAAAGAAGAAGAGAGAAAGAAAAAGAAGGAGAAGGCTGCTGCAGCCAAAGTTGAACTTGTGAAAGAGAGCACTGAAAAGAAAAGAGAG AAAAAGGTGCTGGACATCCCCTCAAAGTATGACTGGTCAGGAGCAGAGGAGTCTGATGATGAGAATGCTGTGTGCGCAGCACAGAACTGC CAAAGGCCCTGCAAGGACAAGGTAGACTGGGTACAATGTGATGGTGGCTGTGATGAGTGGTTTCATCAAGTTTGTGTGGGTGTATCTCCA GAAATGGCTGAAAATGAAGATTACATCTGTATAAACTGTGCAAAGAAGCAGGGGCCAGTTAGCCCAGGTCCAGCACCACCTCCTTCCTTC ATAATGAGCTACAAACTACCAATGGAGGATCTTAAAGAGACCAGTTAGCAGATGCTTGGTTAGTTTGGGACATGGGGGGACATGGACCAC ATTGAGACCTTAGTCATCAAGTAGAGTGGTTTATATCCACTTGGAATGTTGCTTCCAAAGATGAATGGCCTTCAGAGAAAGTCCCCTTAG TGCTGGCTTCCTCTTTGCATGGACTCTGTGGGTTACATTCTCTATCAACATATCTATGCAGAGGGTGTCTTCTTTGGTACAACAGCCAAT ATTTCATGTCTCCTTTGAGTGTGGTTTACTGCATTAAGGCCAGATGCTTAATTGAGCTCTAGGGTGGCTGGTTAGTATTAATACATTGGT GTGCTAACAGGGCATATAGGATGTGGCTTTTGTCCAGCTGATAGTAGTTAGAGGCTTACAACTTAGGAGCAGCACCAACTGAAGGTGCTA ATTGCTTGGATCTCCTTCATTGGGATAGTTGGAGAGGGATTGGAGTACCACTTTCCTTCCACTGTTACCTGGTACTTAATGCCCTAAAGA TACAACTAGGAGTAACAGGGCCAAAGTTATTTCTGTTAGACGTCAAGGAATGGTATCACAGTCTATTGACCTCAGCGATTTGTGCTTGTT TGTGCTAGAAGAACATCCCAAATAGGAGAACCTCTCACAAGCTGGGGCAGGTCACCTTATCTTTGTAAGATGAGGATATCATCTAGATCA GAAATCTGACTAGATTGGATTCTGAGGAGAAGAACCTACTACAAGGCAAGGAGCCGTTTTTTGGCTTTGAAAAGTCTTGCTGTCTTGGGT CTACATTTTAGGGAAGAGCAGGTACATGGATCCAGGCTTCTGCCAAAAAAAAAAAGAGAAGAAGATGACGATGATGACCAGTCGTACTAT CTTACTGAGCCACAGTGATGCATGCTTTTCGGGGAAAACTTCATTCACAAGTATTCCAGACACCAGGCTTCAGGCATGGCCATGAGCAAG ACCAGCAAATAACAGCTTTTTGCCTTGCAGCCCTGACCCCAATGTCTGCTGTTTCCAACACTGGTGATTTCTAACTACGGCCCACAGCAG ATGCTGTTGAATAACACCATGGCTTCATCAGAGGATGTGGGGTTGTAGTACCTCTGGGTGATGAAGTTGTTTTAGTAAATCCATTTTTAA AAAAAAAAAAGGACTTGTTTTTACTTTTTTCTAAATGTCTCTGACTACTGACTGTTCTATACATAGATTATTTTTCCTTTTTTAATATAC ATATATGAATATATAAATATATATATTTACTGTTACCAGCAGCATATGACAGAGTTTCAACATCAAAAATCCATTTGGGGGCTTGCTTTT TCTTTTTTGCTTTAAAAAAAAAAATCCCATTCCTTCTTTGTAGTACAAGGAGTTAGCACTCCCTCCTCCATCCCAGCCTGACCAGATCTT CCATTTTGCTTTTGTTCATATAGATAATTATATGTCCTTTGTGTGTTGGGACTTGTCCCTGTCTGTTGGGAAACTTGGTCTCACTCTAGT CTGTGCTGGCTCTTTTTTCTTTTGTGTGTGAATGTTTGAAACTATGGTGCTGTGTCCTCTTCCCTCCTGTTGTGTTCTCTGTTCTTCTTA AGGTATTAGGTAAGCTGTATGTAAACTCTTATTAGAAGGGGACTAATTTTTTTTTAAAGGACAAAAAAAAAAATGACTAAAAATAGTGTT TTGTCATCACTGTCTGGTGTCTTTATTTTGGTTTAAAAAAATCTGTGGTTTGACTTAAATTCATCAGTTTTCCTTTTAAAGGGGGGATTG GGGTGGACCTAGCAACAGCTTATAGTTTCCTCTTCCCTTTTTGCCCCAGTCTCTTTTAAAGAACTGTCTTCTAGTAACTAGAAGTGAAAT GTACTGTCCAGTTACAGTTTGAGTGGGTATGAGATTTAACTCAAAAGGAATCTTACAAAAAAAAAGATGTTTTCTTATAAAATCCAATTT CTGTAAATGTTTTCTCTGAAGTTCATACTACCTACTTTTTATTCATTCTTAATACTGTATAACATTTTGAGTGTTTTGACTTGTTCAGAG GTTTGTTAGTGTTGCTGTGCATATGTCTTGAGGTCTCATCTGAAGTAAGTTTGTGTATGATCGAAGATTTCAATGGATATTGCAAGGTAA CTAATTAACTGATTTCATAAGTTTTCGTTTTGCCAAGCTAACGATTATCAATTAAGAATTTCCTCTGGTTGATGTTATACAAGAAAGCAC AATATTTTTTGCCTGTTGATCTTCTTTGTAACAGTCTTCAGATATTTGTGGGTTAAAAATTGAATGTAATTTTAAGTGACAGATGCCTGG AATACATTTAAAATTTTTATTTTTCCTTCCTAATCATCCATTAACTATTCCACTATCAGTGGAGAGTCATGAGGATGCTGAGAAAGTATG AATAGCTTCCTGTCACCTTCTGACGTTTTGAAACTTAAATATGTCTTTTCGTTGATACTGTGGGATTTTCTGTATTTACTTGACAGTCAT GGAGGATTTGGTATGACTTGACCACAGGTTTAGACCAAGGCTGAGAAGAACAGAAGGGAGAAATTAATGGCAAAACAAAAAATACACAAA TCTGCGGTTTTGGAATTAATGAAACAAGATTCATCTATTTAAAGAAATGTTGGTGTTCTAATACAAAGCATTATTTTCACTTAGAGAAAA TTACTTACTTGCTCCCTTCTGTATTGTAATATTTTGTATTAAGACATGATTTAAAATGTCTTTCTACCCTTATCTCCTCTAAACTGCAAC TGAAGTTGCAATTCTTCATCATTAGTATTTTAACTCTGGCAAAGGTTATAGAAAGAAAAATGGAAATATGGTAGGCCTGTGGTATTCTTA AAAGCTAAGTCATTAGAACTATGCAGATCCCCAAGTTTAAAAGTACAAATACAGCACCAGTAGTTAGCTTTCTAGCTGGGGGAGAAGACA GGAGATTTTTCTTCCACAGATGTTTATTTTGCTTCCTGATAGGTACTGCAGCAAAGCCATGTTGATGTGTAGATGCATGACTTCCTCACT AAGCTGCTGCACACCAGCTTTGCCTGCATGATTCAAATTTGTGCCTCAGTAAAATTATAAATTATTGCATGTCATACCTTGAATAATGGA AACGGCAAACATTAAACCTGTGATTACCCATAATGTACTTTAATAATAAAAAACATGGCAGCCAGGTGCAGTAGAGTGCACCTGTGGTCA GGAGGCTGAAGTGGGAAGATTGCTTCAACCTGTGAGTTTGAGTCCCGCCTGGTCAACAGCGAGACCCCATGTGTCTGTCTGTCTCTCTCT TTTTTTAAAGGACAGAGGCTAAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGTGCTTCTGTGCAGGCTGAGCTGTAAGGT TAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCG CTTCTGTGCAGGCTGAGCTGTAAGGTTAGCATGGTTCTGCCTGGGCTTTGCTTCTGCGCTTCTGTGCTAGCAGGTGCCCACAAAATGTCT TTTTGAATTTCTTAATTTTTGGGTTCTGGATGCAATTCGTGCACGCCAAGAAACTACTTGCTTGTCAGTATTTTAATTCTGTAGTACATG TGTGTGAATATCAGCCAGTACTTACAGTAGGAGGATGAACAGAAAAACTGAGAAGACCTGTCTTTCAAAAGATGGGTTTATCCACTTTTT AAGGGAAAAAGTGACAGTTTGGCATGGGATTTGAAAAGTGGAAATTGTGGAAAAATTGAGCTGTTGAAGTCCCACATATAACCAGATTTA ATAAAGCTTCACATGTGAATTAGCTCCATATGTGTGTAGAAGGTTGCTTTTATAGCAGGTCCTTAAGTACTCCTTTTGAAATTCCTCCTT TTTTTTTAAGTCATACCATTACTTCTTTGGATATGAATGTCCCAAGTGGTATCTCCTACTGTAGTATGAGGAAGAATGGCTGTTAATGTA TTTTTTGAATTTTGGTCTTGTCTTGGCCTGGATCATATCCAGTCACCACTATGCAACAAATGATGTGCACTGGGCAAGGATATGATGGGT TATGAAAGCTGTATCTTGTTTGTTTTTTCTTTTGCAGTACTCCAAGTGGTCTAAACAGGAATGTCTTGTAAAACCTCAAGACTCCCTATT GATTATTCCCTTACATATTTATTTACAATTTATCAGGGTAATTGGTGGTGCCTTATGAAAAGTATAACTCGATTTCTTGATCTTTGAGCA TGTTTTGTGTTTCTTGTGTTTTCTAAAAGAATATTAGATATGGTTAATTGCATTACATCTAAAAGATTTAAAAAATTGTGTGTATGCTCA GGTTCCCCACACCCATACCCACCCTAACCCCTGTCATTTACATTGGTGGCAACTTTAAATGGTAACCAAGCAAAAGTACATTTTGATAAT GAGTATTGATAATCCTGAGGAAAACTAGTGAGTATATGGGAGCCACCTTTGACCTGTGCCAAAGCAGTTTCTAATTTCATTTGCTAACTA TAAAATAAAGAACTGAGCCAAAATAATTTGATCAGTGGTGTGATTAGCCTATTATCATTGCTGAGAATAGTGTTTTTGGAGTGTGAAGTG ATTCCTGAAGATTTCACCTGCCTTCTGTTTCCAGCAAGAATCCAGTGATGACCAACACATTTCCTCACTTTTGGTTCTTGAGAAGTTTAT CCCTTTGCAACAAACCATTAATAGGGAAAACAAGGAAATGCTTTCCCTTTCTCTTTGGCTTCTTAAAGCTCACAACCAATTCAGACCCCA AGTTACTTCAGAGAAGCAAATGGCACCTTTTCCCCATTGCCAAGGATCCCAGCTTATGCAGATATGAAGGACGGATCATTTCTGAAAATG TTAAGACTCTGCTTGCAGTGGACTTGGCCTCAGTTTCATGAAATGTGTAACTCTGTATGTGTATGTTAGGAGGAGGGTTGGTTGAAAGAG CGGGGGCAGGGAGGGGAATCTGATTACCTCTTGGGAAATAATTTTCTTGCCAACAAAAAGATACACTTGAAGTTTCTTAAGGTGGCAAGT CCATTAAAAAAAAAAATTGTGTTGGACCCTCCCAGTTTAGATCAAGTATTTCTTGGGGGTCTTGCTATTGTGGTTGATACCAATAAATGG AAGATCCAGAATATTTTCATTTAAAGCTCAACCATTAATTGGAACATGGTGAAACATTGTACACATTGTAAAAGTAGGGAACAGTACAAA |
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FusionGenePPI for TSKU_KDM5A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSKU_KDM5A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSKU_KDM5A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | KDM5A | C3714756 | Intellectual Disability | 1 | CTD_human |
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