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Fusion gene ID: 39778 |
FusionGeneSummary for TSHZ1_RNASEH2B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSHZ1_RNASEH2B | Fusion gene ID: 39778 | Hgene | Tgene | Gene symbol | TSHZ1 | RNASEH2B | Gene ID | 10194 | 79621 |
| Gene name | teashirt zinc finger homeobox 1 | ribonuclease H2 subunit B | |
| Synonyms | CAA|NY-CO-33|SDCCAG33|TSH1 | AGS2|DLEU8 | |
| Cytomap | 18q22.3 | 13q14.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | teashirt homolog 1antigen NY-CO-33serologically defined colon cancer antigen 33 | ribonuclease H2 subunit BAicardi-Goutieres syndrome 2 proteinRNase H2 subunit Bdeleted in lymphocytic leukemia 8ribonuclease HI subunit B | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6ZSZ6 | Q5TBB1 | |
| Ensembl transtripts involved in fusion gene | ENST00000322038, ENST00000580243, | ENST00000336617, ENST00000422660, ENST00000495244, | |
| Fusion gene scores | * DoF score | 3 X 5 X 2=30 | 5 X 3 X 4=60 |
| # samples | 4 | 5 | |
| ** MAII score | log2(4/30*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TSHZ1 [Title/Abstract] AND RNASEH2B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RNASEH2B | GO:0006401 | RNA catabolic process | 21177858 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-KF-A41W-01A | TSHZ1 | chr18 | 72923198 | + | RNASEH2B | chr13 | 51501543 | + |
| TCGA | LD | SARC | TCGA-KF-A41W-01A | TSHZ1 | chr18 | 72923871 | + | RNASEH2B | chr13 | 51501543 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000322038 | ENST00000336617 | TSHZ1 | chr18 | 72923198 | + | RNASEH2B | chr13 | 51501543 | + |
| 5UTR-3CDS | ENST00000322038 | ENST00000422660 | TSHZ1 | chr18 | 72923198 | + | RNASEH2B | chr13 | 51501543 | + |
| 5UTR-intron | ENST00000322038 | ENST00000495244 | TSHZ1 | chr18 | 72923198 | + | RNASEH2B | chr13 | 51501543 | + |
| intron-3CDS | ENST00000580243 | ENST00000336617 | TSHZ1 | chr18 | 72923198 | + | RNASEH2B | chr13 | 51501543 | + |
| intron-3CDS | ENST00000580243 | ENST00000422660 | TSHZ1 | chr18 | 72923198 | + | RNASEH2B | chr13 | 51501543 | + |
| intron-intron | ENST00000580243 | ENST00000495244 | TSHZ1 | chr18 | 72923198 | + | RNASEH2B | chr13 | 51501543 | + |
| intron-3CDS | ENST00000322038 | ENST00000336617 | TSHZ1 | chr18 | 72923871 | + | RNASEH2B | chr13 | 51501543 | + |
| intron-3CDS | ENST00000322038 | ENST00000422660 | TSHZ1 | chr18 | 72923871 | + | RNASEH2B | chr13 | 51501543 | + |
| intron-intron | ENST00000322038 | ENST00000495244 | TSHZ1 | chr18 | 72923871 | + | RNASEH2B | chr13 | 51501543 | + |
| In-frame | ENST00000580243 | ENST00000336617 | TSHZ1 | chr18 | 72923871 | + | RNASEH2B | chr13 | 51501543 | + |
| In-frame | ENST00000580243 | ENST00000422660 | TSHZ1 | chr18 | 72923871 | + | RNASEH2B | chr13 | 51501543 | + |
| 5CDS-intron | ENST00000580243 | ENST00000495244 | TSHZ1 | chr18 | 72923871 | + | RNASEH2B | chr13 | 51501543 | + |
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FusionProtFeatures for TSHZ1_RNASEH2B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSHZ1 | RNASEH2B |
| Probable transcriptional regulator involved indevelopmental processes. May act as a transcriptional repressor(Potential). {ECO:0000305}. | Non catalytic subunit of RNase H2, an endonuclease thatspecifically degrades the RNA of RNA:DNA hybrids. Participates inDNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication.Mediates the excision of single ribonucleotides from DNA:RNAduplexes. {ECO:0000269|PubMed:16845400,ECO:0000269|PubMed:21177858}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSHZ1_RNASEH2B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_TSHZ1_ENST00000580243_chr18_72923871_+_RNASEH2B_ENST00000336617_chr13_51501543_+_305aa MPRRKQQAPRRSAEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLL HYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSR VQSTAFFSGDQASTDKEEDYIRYAHGLISDYIPKELSDDLSKYLKLPEPSASLPNPPSKKIKLSDEPVEAKEDYTKFNTKDLKTEKKNSK >In-frame_TSHZ1_ENST00000580243_chr18_72923871_+_RNASEH2B_ENST00000422660_chr13_51501543_+_250aa MPRRKQQAPRRSAEYLKDASKKMKNGLMFVKLVNPCSGEGAIYLFNMCLQQLFEVKVFKEKHHSWFINQSVQSGGLLHFATPVDPLFLLL HYLIKADKEGKFQPLDQVVVDNVFPNCILLLKLPGLEKLLHHVTEEKGNPEIDNKKYYKYSKEKTLKWLEKKVNQTVAALKTNNVNVSSR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_TSHZ1_ENST00000580243_chr18_72923871_+_RNASEH2B_ENST00000336617_chr13_51501543_+_915nt ATGCCGAGGAGGAAGCAGCAGGCCCCCCGGCGCTCGGCAGAATATTTAAAAGATGCTTCAAAGAAGATGAAAAATGGGCTAATGTTTGTA AAACTGGTTAACCCCTGTTCAGGAGAAGGAGCCATTTACTTGTTCAATATGTGTCTACAGCAGCTGTTTGAAGTAAAAGTTTTCAAGGAA AAACACCATTCTTGGTTTATAAATCAATCAGTTCAATCAGGAGGTCTTCTCCATTTTGCCACACCTGTGGATCCTCTATTTCTGCTTCTC CACTACCTCATAAAGGCTGATAAGGAGGGGAAGTTTCAGCCCCTTGATCAAGTTGTGGTGGATAACGTGTTTCCAAATTGCATCTTGTTG CTGAAACTTCCTGGACTTGAGAAGTTACTTCATCATGTGACAGAGGAAAAAGGTAATCCAGAAATAGACAACAAGAAATATTACAAGTAC AGCAAAGAGAAGACATTAAAGTGGCTGGAAAAAAAGGTTAATCAAACTGTGGCAGCATTAAAAACCAATAATGTGAATGTCAGTTCCCGG GTACAGTCAACTGCATTTTTCTCTGGTGACCAAGCTTCCACTGACAAGGAAGAGGATTATATTCGTTATGCCCATGGTCTGATATCTGAC TACATCCCTAAAGAATTAAGTGATGACTTATCTAAATACTTAAAGCTTCCAGAACCTTCAGCCTCATTGCCAAATCCTCCATCAAAGAAA ATAAAGTTATCAGATGAGCCTGTAGAAGCAAAAGAAGATTACACTAAGTTTAATACTAAAGATTTGAAGACTGAAAAGAAAAATAGCAAA ATGACTGCAGCTCAGAAGGCTTTGGCTAAAGTTGACAAGAGTGGAATGAAAAGTATTGATACCTTTTTTGGGGTAAAAAATAAAAAAAAA >In-frame_TSHZ1_ENST00000580243_chr18_72923871_+_RNASEH2B_ENST00000422660_chr13_51501543_+_750nt ATGCCGAGGAGGAAGCAGCAGGCCCCCCGGCGCTCGGCAGAATATTTAAAAGATGCTTCAAAGAAGATGAAAAATGGGCTAATGTTTGTA AAACTGGTTAACCCCTGTTCAGGAGAAGGAGCCATTTACTTGTTCAATATGTGTCTACAGCAGCTGTTTGAAGTAAAAGTTTTCAAGGAA AAACACCATTCTTGGTTTATAAATCAATCAGTTCAATCAGGAGGTCTTCTCCATTTTGCCACACCTGTGGATCCTCTATTTCTGCTTCTC CACTACCTCATAAAGGCTGATAAGGAGGGGAAGTTTCAGCCCCTTGATCAAGTTGTGGTGGATAACGTGTTTCCAAATTGCATCTTGTTG CTGAAACTTCCTGGACTTGAGAAGTTACTTCATCATGTGACAGAGGAAAAAGGTAATCCAGAAATAGACAACAAGAAATATTACAAGTAC AGCAAAGAGAAGACATTAAAGTGGCTGGAAAAAAAGGTTAATCAAACTGTGGCAGCATTAAAAACCAATAATGTGAATGTCAGTTCCCGG GTACAGTCAACTGCATTTTTCTCTGGTGACCAAGCTTCCACTGACAAGGAAGAGGATTATATTCGTTATGCCCATGGTCTGATATCTGAC TACATCCCTAAAGAATTAAGTGATGACTTATCTAAATACTTAAAGCTTCCAGAACCTTCAGCCTCATTGCCAAATCCTCCATCAAAGATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_TSHZ1_ENST00000580243_chr18_72923871_+_RNASEH2B_ENST00000336617_chr13_51501543_+_1554nt GCATGGAGCGCGGGCCGCGGGCCGGCCCGCCGAGCGCCCGCTGCTGCGCCCGCGGCCCGCGCCGGGGATGACTCCGGGCTCGGCGCCCAG GCCCCGCGCGCTCCGCCCGCAGCCCGGCGCCGGGAAGCGGGCCGCGCGGCCGCCGCCGCCGCCTCCTGAGCGGCCCCGGGCGCGGCGGTC CATGCGAGCGGCTCCCCGCGGTCCGCGGCGCGCCCGGAGCCCGGAGCCCGCGGGGACGAGGCCAAAGTTGGGCGCGCCGCGGAGTTGCGC CCGCGCCCGGGGCCCCGCGTCCCCGCGCCCCGCGAACTCCGGCGGCGGCTGAGGCGACGGCTGCGGCGGCCGAGCAGCATGCCGAGGAGG AAGCAGCAGGCCCCCCGGCGCTCGGCAGAATATTTAAAAGATGCTTCAAAGAAGATGAAAAATGGGCTAATGTTTGTAAAACTGGTTAAC CCCTGTTCAGGAGAAGGAGCCATTTACTTGTTCAATATGTGTCTACAGCAGCTGTTTGAAGTAAAAGTTTTCAAGGAAAAACACCATTCT TGGTTTATAAATCAATCAGTTCAATCAGGAGGTCTTCTCCATTTTGCCACACCTGTGGATCCTCTATTTCTGCTTCTCCACTACCTCATA AAGGCTGATAAGGAGGGGAAGTTTCAGCCCCTTGATCAAGTTGTGGTGGATAACGTGTTTCCAAATTGCATCTTGTTGCTGAAACTTCCT GGACTTGAGAAGTTACTTCATCATGTGACAGAGGAAAAAGGTAATCCAGAAATAGACAACAAGAAATATTACAAGTACAGCAAAGAGAAG ACATTAAAGTGGCTGGAAAAAAAGGTTAATCAAACTGTGGCAGCATTAAAAACCAATAATGTGAATGTCAGTTCCCGGGTACAGTCAACT GCATTTTTCTCTGGTGACCAAGCTTCCACTGACAAGGAAGAGGATTATATTCGTTATGCCCATGGTCTGATATCTGACTACATCCCTAAA GAATTAAGTGATGACTTATCTAAATACTTAAAGCTTCCAGAACCTTCAGCCTCATTGCCAAATCCTCCATCAAAGAAAATAAAGTTATCA GATGAGCCTGTAGAAGCAAAAGAAGATTACACTAAGTTTAATACTAAAGATTTGAAGACTGAAAAGAAAAATAGCAAAATGACTGCAGCT CAGAAGGCTTTGGCTAAAGTTGACAAGAGTGGAATGAAAAGTATTGATACCTTTTTTGGGGTAAAAAATAAAAAAAAAATTGGAAAGGTT TGAAACTTTGAAAATAAAATCTAGCAAAAATATTTGCTTTTTACATGTTTCAGTTTGTCCTTCCTGACTGTTAATGACTACCTTTGGTTG GGGGAAGGAAGAGGCCAATTTCATGTTCTCTTAAACATTTCTTTGCATTTGGTTTTTGTGTTCCTGAACAAAATATGGGAAAGTGTCTAA CTTCATGGCTATGGCCTTTTGGAGTCTCATCTGACATAATGAAAAGTAATCACTTGAAGAGAATTAACATATAGCATCATGATTTTCTCA >In-frame_TSHZ1_ENST00000580243_chr18_72923871_+_RNASEH2B_ENST00000422660_chr13_51501543_+_1590nt GCATGGAGCGCGGGCCGCGGGCCGGCCCGCCGAGCGCCCGCTGCTGCGCCCGCGGCCCGCGCCGGGGATGACTCCGGGCTCGGCGCCCAG GCCCCGCGCGCTCCGCCCGCAGCCCGGCGCCGGGAAGCGGGCCGCGCGGCCGCCGCCGCCGCCTCCTGAGCGGCCCCGGGCGCGGCGGTC CATGCGAGCGGCTCCCCGCGGTCCGCGGCGCGCCCGGAGCCCGGAGCCCGCGGGGACGAGGCCAAAGTTGGGCGCGCCGCGGAGTTGCGC CCGCGCCCGGGGCCCCGCGTCCCCGCGCCCCGCGAACTCCGGCGGCGGCTGAGGCGACGGCTGCGGCGGCCGAGCAGCATGCCGAGGAGG AAGCAGCAGGCCCCCCGGCGCTCGGCAGAATATTTAAAAGATGCTTCAAAGAAGATGAAAAATGGGCTAATGTTTGTAAAACTGGTTAAC CCCTGTTCAGGAGAAGGAGCCATTTACTTGTTCAATATGTGTCTACAGCAGCTGTTTGAAGTAAAAGTTTTCAAGGAAAAACACCATTCT TGGTTTATAAATCAATCAGTTCAATCAGGAGGTCTTCTCCATTTTGCCACACCTGTGGATCCTCTATTTCTGCTTCTCCACTACCTCATA AAGGCTGATAAGGAGGGGAAGTTTCAGCCCCTTGATCAAGTTGTGGTGGATAACGTGTTTCCAAATTGCATCTTGTTGCTGAAACTTCCT GGACTTGAGAAGTTACTTCATCATGTGACAGAGGAAAAAGGTAATCCAGAAATAGACAACAAGAAATATTACAAGTACAGCAAAGAGAAG ACATTAAAGTGGCTGGAAAAAAAGGTTAATCAAACTGTGGCAGCATTAAAAACCAATAATGTGAATGTCAGTTCCCGGGTACAGTCAACT GCATTTTTCTCTGGTGACCAAGCTTCCACTGACAAGGAAGAGGATTATATTCGTTATGCCCATGGTCTGATATCTGACTACATCCCTAAA GAATTAAGTGATGACTTATCTAAATACTTAAAGCTTCCAGAACCTTCAGCCTCATTGCCAAATCCTCCATCAAAGATGGCAGCACAAAGA CAGAAAAGGGGCAAGTGATGGTGGTGGCTCCACGCAAGGCTTGGCGGTTTTCCCTGCAACTTCAGACACTCCCAGAGGACTCGGACTTTT TCTTCTGCACTTTTTTGGAAAATCGCCAGGTGCCAAAAGGTGCATTTTAAAGCGCTGACTGTAAATGCTTTATTTCTTTGATTAGTACCA CTAGTCTATGTGGGCAGCGGCATTCCTCCCTGGAGCACTCAGCTAGGCGGTTCCGTCCAGGAGCTTGAAAGCATCCCAGCGGTGCACCTG TTCAGTCTGAGGACCTCAAGCTTGGGTCAGGCCAGCATGTTTTAGGTATGGATGTGGTGACTTAAAGTACTTGATTGTCTTGATTTCACC CTGAAAGCTTTGGCAAACCAAGTTTCAACCCTTACTTTAAAAATCTGACACTGCTTTACTCCATATCAATTTGGAAGCTTCTAATTCATA |
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FusionGenePPI for TSHZ1_RNASEH2B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TSHZ1 | APBB1, FOXJ2 | RNASEH2B | RNASEH2C, RNASEH2A, NRAS, ANP32E, DNAJB1, RDX, UBQLN2, AP1M1, FERMT1, VBP1, HIST1H2BG, ABCA2, CLPTM1, FOXM1, HIVEP1, PSMD5, RRM1, MKNK1, RABGAP1L, ARPC5, SAP18, STAMBP, YWHAQ, CEP164, TNRC6B, SYNE2, KLHDC2, ATP5S, KCTD3, BCOR, SLC39A10, THOC2, RNF213, PDF, HERPUD2, ZMYM1, C1orf52, DAB2IP, BRINP1, WT1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSHZ1_RNASEH2B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSHZ1_RNASEH2B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TSHZ1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | RNASEH2B | C3489724 | Aicardi-Goutieres Syndrome 2 | 2 | UNIPROT |
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