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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39777

FusionGeneSummary for TSHZ1_BGN

check button Fusion gene summary
Fusion gene informationFusion gene name: TSHZ1_BGN
Fusion gene ID: 39777
HgeneTgene
Gene symbol

TSHZ1

BGN

Gene ID

10194

633

Gene nameteashirt zinc finger homeobox 1biglycan
SynonymsCAA|NY-CO-33|SDCCAG33|TSH1DSPG1|MRLS|PG-S1|PGI|SEMDX|SLRR1A
Cytomap

18q22.3

Xq28

Type of geneprotein-codingprotein-coding
Descriptionteashirt homolog 1antigen NY-CO-33serologically defined colon cancer antigen 33biglycanbone/cartilage proteoglycan-Idermatan sulphate proteoglycan Ismall leucine-rich protein 1A
Modification date2018052320180522
UniProtAcc

Q6ZSZ6

P21810

Ensembl transtripts involved in fusion geneENST00000322038, ENST00000580243, 
ENST00000331595, ENST00000480756, 
Fusion gene scores* DoF score3 X 5 X 2=307 X 7 X 2=98
# samples 47
** MAII scorelog2(4/30*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TSHZ1 [Title/Abstract] AND BGN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AX746813TSHZ1chr18

72999940

+BGNchrX

152774612

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000322038ENST00000331595TSHZ1chr18

72999940

+BGNchrX

152774612

+
5CDS-3UTRENST00000322038ENST00000480756TSHZ1chr18

72999940

+BGNchrX

152774612

+
5CDS-3UTRENST00000580243ENST00000331595TSHZ1chr18

72999940

+BGNchrX

152774612

+
5CDS-3UTRENST00000580243ENST00000480756TSHZ1chr18

72999940

+BGNchrX

152774612

+

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FusionProtFeatures for TSHZ1_BGN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSHZ1

Q6ZSZ6

BGN

P21810

Probable transcriptional regulator involved indevelopmental processes. May act as a transcriptional repressor(Potential). {ECO:0000305}. May be involved in collagen fiber assembly.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSHZ1_BGN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSHZ1_BGN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSHZ1_BGN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TSHZ1_BGN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTSHZ1C0005586Bipolar Disorder1PSYGENET
TgeneBGNC0003873Rheumatoid Arthritis1CTD_human
TgeneBGNC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneBGNC1848097Spondyloepimetaphyseal Dysplasia, X-Linked1ORPHANET;UNIPROT