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Fusion gene ID: 39774 |
FusionGeneSummary for TSG101_YWHAB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSG101_YWHAB | Fusion gene ID: 39774 | Hgene | Tgene | Gene symbol | TSG101 | YWHAB | Gene ID | 7251 | 7529 |
| Gene name | tumor susceptibility 101 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta | |
| Synonyms | TSG10|VPS23 | GW128|HEL-S-1|HS1|KCIP-1|YWHAA | |
| Cytomap | 11p15.1 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tumor susceptibility gene 101 proteinESCRT-I complex subunit TSG101tumor susceptibility gene 10tumor susceptibility gene 101tumor susceptibility protein | 14-3-3 protein beta/alpha14-3-3 alphabrain protein 14-3-3, beta isoformepididymis secretory protein Li 1protein 1054protein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptidetyrosin | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q99816 | P31946 | |
| Ensembl transtripts involved in fusion gene | ENST00000536719, ENST00000251968, ENST00000357193, ENST00000543087, | ENST00000353703, ENST00000479421, ENST00000372839, | |
| Fusion gene scores | * DoF score | 4 X 4 X 2=32 | 4 X 7 X 2=56 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/56*10)=0.684498174272071 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TSG101 [Title/Abstract] AND YWHAB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TSG101 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 15611048 |
| Tgene | YWHAB | GO:0035308 | negative regulation of protein dephosphorylation | 17255105 |
| Tgene | YWHAB | GO:0043085 | positive regulation of catalytic activity | 17255105 |
| Tgene | YWHAB | GO:0051220 | cytoplasmic sequestering of protein | 10869435 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BQ961579 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000536719 | ENST00000353703 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3UTR | ENST00000536719 | ENST00000479421 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3UTR | ENST00000536719 | ENST00000372839 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3CDS | ENST00000251968 | ENST00000353703 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3UTR | ENST00000251968 | ENST00000479421 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3UTR | ENST00000251968 | ENST00000372839 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3CDS | ENST00000357193 | ENST00000353703 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3UTR | ENST00000357193 | ENST00000479421 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3UTR | ENST00000357193 | ENST00000372839 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3CDS | ENST00000543087 | ENST00000353703 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3UTR | ENST00000543087 | ENST00000479421 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
| intron-3UTR | ENST00000543087 | ENST00000372839 | TSG101 | chr11 | 18512062 | - | YWHAB | chr20 | 43530206 | + |
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FusionProtFeatures for TSG101_YWHAB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSG101 | YWHAB |
| Component of the ESCRT-I complex, a regulator ofvesicular trafficking process. Binds to ubiquitinated cargoproteins and is required for the sorting of endocyticubiquitinated cargos into multivesicular bodies (MVBs). Mediatesthe association between the ESCRT-0 and ESCRT-I complex. Requiredfor completion of cytokinesis; the function requires CEP55. May beinvolved in cell growth and differentiation. Acts as a negativegrowth regulator. Involved in the budding of many viruses throughan interaction with viral proteins that contain a late-buddingmotif P-[ST]-A-P. This interaction is essential for viral particlebudding of numerous retroviruses. Required for the exosomalrelease of SDCBP, CD63 and syndecan (PubMed:22660413). It may alsoplay a role in the extracellular release of microvesicles thatdiffer from the exosomes (PubMed:22315426).{ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548,ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952,ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426,ECO:0000269|PubMed:22660413}. | Adapter protein implicated in the regulation of a largespectrum of both general and specialized signaling pathways. Bindsto a large number of partners, usually by recognition of aphosphoserine or phosphothreonine motif. Binding generally resultsin the modulation of the activity of the binding partner. Negativeregulator of osteogenesis. Blocks the nuclear translocation of thephosphorylated form (by AKT1) of SRPK2 and antagonizes itsstimulatory effect on cyclin D1 expression resulting in blockageof neuronal apoptosis elicited by SRPK2. Negative regulator ofsignaling cascades that mediate activation of MAP kinases viaAKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491,ECO:0000269|PubMed:21224381}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSG101_YWHAB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSG101_YWHAB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSG101_YWHAB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSG101_YWHAB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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