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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3977

FusionGeneSummary for BCAS4_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: BCAS4_BCAS3
Fusion gene ID: 3977
HgeneTgene
Gene symbol

BCAS4

BCAS3

Gene ID

55653

54828

Gene namebreast carcinoma amplified sequence 4BCAS3, microtubule associated cell migration factor
SynonymsCNOLGAOB1|MAAB
Cytomap

20q13.13

17q23.2

Type of geneprotein-codingprotein-coding
Descriptionbreast carcinoma-amplified sequence 4BCAS4/BCAS3 fusionbreast carcinoma amplified sequence 4/3 fusion proteinbreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

Q8TDM0

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000358791, ENST00000262591, 
ENST00000371608, ENST00000609336, 
ENST00000485049, 
ENST00000589222, 
ENST00000407086, ENST00000390652, 
ENST00000408905, ENST00000588462, 
ENST00000585744, ENST00000588874, 
ENST00000585812, 
Fusion gene scores* DoF score5 X 5 X 7=17526 X 15 X 15=5850
# samples 1641
** MAII scorelog2(16/175*10)=-0.129283016944966
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BCAS4 [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. (pmid: 12378525)
Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-CJ-5683-01ABCAS4chr20

49411710

+BCAS3chr17

59445688

+
ChiTaRS3.1BU944756BCAS4chr20

49411713

+BCAS3chr17

59445686

+
ChiTaRS3.1BU943989BCAS4chr20

49411713

+BCAS3chr17

59445686

+
ChiTaRS3.1BU539346BCAS4chr20

49411713

+BCAS3chr17

59445686

+
ChiTaRS3.1AF361221BCAS4chr20

49411713

+BCAS3chr17

59445686

+
ChiTaRS3.1BU944045BCAS4chr20

49411713

+BCAS3chr17

59445686

+
ChiTaRS3.1CA455392BCAS4chr20

49411713

+BCAS3chr17

59445686

+
ChiTaRS3.1BU955765BCAS4chr20

49411713

+BCAS3chr17

59445686

+
ChiTaRS3.1BU957509BCAS4chr20

49411713

+BCAS3chr17

59445686

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000358791ENST00000589222BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000358791ENST00000407086BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000358791ENST00000390652BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000358791ENST00000408905BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000358791ENST00000588462BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000358791ENST00000585744BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000358791ENST00000588874BCAS4chr20

49411710

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000358791ENST00000585812BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000262591ENST00000589222BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000262591ENST00000407086BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000262591ENST00000390652BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000262591ENST00000408905BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000262591ENST00000588462BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000262591ENST00000585744BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000262591ENST00000588874BCAS4chr20

49411710

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000262591ENST00000585812BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000371608ENST00000589222BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000371608ENST00000407086BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000371608ENST00000390652BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000371608ENST00000408905BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000371608ENST00000588462BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000371608ENST00000585744BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000371608ENST00000588874BCAS4chr20

49411710

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000371608ENST00000585812BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000609336ENST00000589222BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000609336ENST00000407086BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000609336ENST00000390652BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000609336ENST00000408905BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000609336ENST00000588462BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000609336ENST00000585744BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000609336ENST00000588874BCAS4chr20

49411710

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000609336ENST00000585812BCAS4chr20

49411710

+BCAS3chr17

59445688

+
3UTR-3CDSENST00000485049ENST00000589222BCAS4chr20

49411710

+BCAS3chr17

59445688

+
3UTR-3CDSENST00000485049ENST00000407086BCAS4chr20

49411710

+BCAS3chr17

59445688

+
3UTR-3CDSENST00000485049ENST00000390652BCAS4chr20

49411710

+BCAS3chr17

59445688

+
3UTR-3CDSENST00000485049ENST00000408905BCAS4chr20

49411710

+BCAS3chr17

59445688

+
3UTR-3CDSENST00000485049ENST00000588462BCAS4chr20

49411710

+BCAS3chr17

59445688

+
3UTR-3CDSENST00000485049ENST00000585744BCAS4chr20

49411710

+BCAS3chr17

59445688

+
3UTR-3CDSENST00000485049ENST00000588874BCAS4chr20

49411710

+BCAS3chr17

59445688

+
3UTR-3UTRENST00000485049ENST00000585812BCAS4chr20

49411710

+BCAS3chr17

59445688

+
Frame-shitENST00000358791ENST00000589222BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000358791ENST00000407086BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000358791ENST00000390652BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000358791ENST00000408905BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000358791ENST00000588462BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000358791ENST00000585744BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000358791ENST00000588874BCAS4chr20

49411713

+BCAS3chr17

59445686

+
5CDS-3UTRENST00000358791ENST00000585812BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000262591ENST00000589222BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000262591ENST00000407086BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000262591ENST00000390652BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000262591ENST00000408905BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000262591ENST00000588462BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000262591ENST00000585744BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000262591ENST00000588874BCAS4chr20

49411713

+BCAS3chr17

59445686

+
5CDS-3UTRENST00000262591ENST00000585812BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000371608ENST00000589222BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000371608ENST00000407086BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000371608ENST00000390652BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000371608ENST00000408905BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000371608ENST00000588462BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000371608ENST00000585744BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000371608ENST00000588874BCAS4chr20

49411713

+BCAS3chr17

59445686

+
5CDS-3UTRENST00000371608ENST00000585812BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000609336ENST00000589222BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000609336ENST00000407086BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000609336ENST00000390652BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000609336ENST00000408905BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000609336ENST00000588462BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000609336ENST00000585744BCAS4chr20

49411713

+BCAS3chr17

59445686

+
Frame-shitENST00000609336ENST00000588874BCAS4chr20

49411713

+BCAS3chr17

59445686

+
5CDS-3UTRENST00000609336ENST00000585812BCAS4chr20

49411713

+BCAS3chr17

59445686

+
3UTR-3CDSENST00000485049ENST00000589222BCAS4chr20

49411713

+BCAS3chr17

59445686

+
3UTR-3CDSENST00000485049ENST00000407086BCAS4chr20

49411713

+BCAS3chr17

59445686

+
3UTR-3CDSENST00000485049ENST00000390652BCAS4chr20

49411713

+BCAS3chr17

59445686

+
3UTR-3CDSENST00000485049ENST00000408905BCAS4chr20

49411713

+BCAS3chr17

59445686

+
3UTR-3CDSENST00000485049ENST00000588462BCAS4chr20

49411713

+BCAS3chr17

59445686

+
3UTR-3CDSENST00000485049ENST00000585744BCAS4chr20

49411713

+BCAS3chr17

59445686

+
3UTR-3CDSENST00000485049ENST00000588874BCAS4chr20

49411713

+BCAS3chr17

59445686

+
3UTR-3UTRENST00000485049ENST00000585812BCAS4chr20

49411713

+BCAS3chr17

59445686

+

Top

FusionProtFeatures for BCAS4_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BCAS4

Q8TDM0

BCAS3

Q9H6U6


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for BCAS4_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for BCAS4_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
BCAS4DTNBP1, PKD2, BLOC1S6, BLOC1S2, BLOC1S5, BLOC1S1, LOH12CR1, ATG4A, SNAPIN, BLOC1S3, SRCIN1BCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for BCAS4_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for BCAS4_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource