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Fusion gene ID: 39766 |
FusionGeneSummary for TSFM_METTL21B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TSFM_METTL21B | Fusion gene ID: 39766 | Hgene | Tgene | Gene symbol | TSFM | METTL21B | Gene ID | 10102 |
| Gene name | Ts translation elongation factor, mitochondrial | ||
| Synonyms | EFTS|EFTSMT | ||
| Cytomap | 12q14.1 | ||
| Type of gene | protein-coding | ||
| Description | elongation factor Ts, mitochondrialEF-TsEF-TsMtmitochondrial elongation factor Ts | ||
| Modification date | 20180523 | ||
| UniProtAcc | P43897 | ||
| Ensembl transtripts involved in fusion gene | ENST00000543727, ENST00000550559, ENST00000548851, ENST00000454289, ENST00000540550, ENST00000323833, ENST00000350762, ENST00000497617, | ENST00000548256, ENST00000551420, ENST00000300209, ENST00000552307, ENST00000333012, | |
| Fusion gene scores | * DoF score | 20 X 6 X 5=600 | 3 X 2 X 2=12 |
| # samples | 19 | 3 | |
| ** MAII score | log2(19/600*10)=-1.65896308216493 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TSFM [Title/Abstract] AND METTL21B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TSFM | GO:0070129 | regulation of mitochondrial translation | 27677415 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | GBM | TCGA-06-2559-01A | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000543727 | ENST00000548256 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000543727 | ENST00000551420 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000543727 | ENST00000300209 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000543727 | ENST00000552307 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000543727 | ENST00000333012 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| In-frame | ENST00000550559 | ENST00000548256 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000550559 | ENST00000551420 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000550559 | ENST00000300209 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000550559 | ENST00000552307 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000550559 | ENST00000333012 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| In-frame | ENST00000548851 | ENST00000548256 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000548851 | ENST00000551420 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000548851 | ENST00000300209 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000548851 | ENST00000552307 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000548851 | ENST00000333012 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| In-frame | ENST00000454289 | ENST00000548256 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000454289 | ENST00000551420 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000454289 | ENST00000300209 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000454289 | ENST00000552307 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000454289 | ENST00000333012 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| In-frame | ENST00000540550 | ENST00000548256 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000540550 | ENST00000551420 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000540550 | ENST00000300209 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000540550 | ENST00000552307 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000540550 | ENST00000333012 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| In-frame | ENST00000323833 | ENST00000548256 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000323833 | ENST00000551420 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-5UTR | ENST00000323833 | ENST00000300209 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000323833 | ENST00000552307 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5CDS-3UTR | ENST00000323833 | ENST00000333012 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5UTR-3CDS | ENST00000350762 | ENST00000548256 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5UTR-5UTR | ENST00000350762 | ENST00000551420 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5UTR-5UTR | ENST00000350762 | ENST00000300209 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5UTR-3UTR | ENST00000350762 | ENST00000552307 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 5UTR-3UTR | ENST00000350762 | ENST00000333012 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 3UTR-3CDS | ENST00000497617 | ENST00000548256 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 3UTR-5UTR | ENST00000497617 | ENST00000551420 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 3UTR-5UTR | ENST00000497617 | ENST00000300209 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 3UTR-3UTR | ENST00000497617 | ENST00000552307 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
| 3UTR-3UTR | ENST00000497617 | ENST00000333012 | TSFM | chr12 | 58177066 | + | METTL21B | chr12 | 58166800 | + |
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FusionProtFeatures for TSFM_METTL21B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TSFM | METTL21B |
| Associates with the EF-Tu.GDP complex and induces theexchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.{ECO:0000255|HAMAP-Rule:MF_03135, ECO:0000269|PubMed:27677415}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >METTL21B | chr12:58177066 | chr12:58166800 | ENST00000300209 | + | 0 | 3 | 83_85 | 59 | 227 | Region | S-adenosyl-L-methionine binding |
| Tgene | >METTL21B | chr12:58177066 | chr12:58166800 | ENST00000333012 | + | 0 | 4 | 83_85 | 59 | 150 | Region | S-adenosyl-L-methionine binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSFM_METTL21B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSFM_METTL21B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TSFM | MTRNR2L1, MRRF, ACOT13, CDV3, C1QBP, LIG4, SLC25A41, ACTL6A, CYP1A1, OXLD1, OFD1, FBF1, DCTN1, NDUFS3, NME4, ATXN7L2, AMY1C, MTIF2, CST2, MRPL12, CST4, ZG16B, GTF2E2, PUS1, IGHA1, ATP5D, DLD, DLST, TRIM25 | METTL21B | ELAVL1, BAG2, BAG6, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT6B, CCT7, CCT8, CTSB, DNAJA1, DNAJA2, HSP90AA1, HSP90AB1, HSP90AB2P, HSP90AB4P, HSPA1L, HSPA2, HSPA5, HSPA7, HSPA8, HSPD1, HUWE1, IGBP1, CCAR2, LAMP2, LDHA, LDHB, MDH2, NTPCR, PDCD5, PFDN1, PFDN2, PFDN4, PFDN5, PFDN6, PPP6C, RNF126, RUVBL1, RUVBL2, SAR1A, SMC1A, SMC3, STIP1, TCP1, TIPRL, TUBB2A, TUBB3, TUBB4A, TUBB6, TUBB8, TUBBP5, UBA1, UBB, UBC, UBL4A, VBP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSFM_METTL21B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TSFM_METTL21B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TSFM | C1864840 | Combined Oxidative Phosphorylation Deficiency 3 | 2 | CTD_human;ORPHANET;UNIPROT |
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