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Fusion gene ID: 39745 |
FusionGeneSummary for TSEN2_PPARG |
Fusion gene summary |
Fusion gene information | Fusion gene name: TSEN2_PPARG | Fusion gene ID: 39745 | Hgene | Tgene | Gene symbol | TSEN2 | PPARG | Gene ID | 80746 | 5468 |
Gene name | tRNA splicing endonuclease subunit 2 | peroxisome proliferator activated receptor gamma | |
Synonyms | PCH2B|SEN2|SEN2L | CIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgamma | |
Cytomap | 3p25.2 | 3p25.2 | |
Type of gene | protein-coding | protein-coding | |
Description | tRNA-splicing endonuclease subunit Sen2TSEN2 tRNA splicing endonuclease subunithsSen2tRNA-intron endonuclease Sen2 | peroxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q8NCE0 | P37231 | |
Ensembl transtripts involved in fusion gene | ENST00000314571, ENST00000383797, ENST00000454502, ENST00000402228, ENST00000444864, ENST00000284995, ENST00000415684, ENST00000475595, | ENST00000397010, ENST00000309576, ENST00000397015, ENST00000397012, ENST00000397026, ENST00000397000, ENST00000539812, ENST00000287820, | |
Fusion gene scores | * DoF score | 5 X 6 X 3=90 | 8 X 5 X 4=160 |
# samples | 7 | 13 | |
** MAII score | log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/160*10)=-0.299560281858908 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: TSEN2 [Title/Abstract] AND PPARG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | TSEN2 | GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation | 17495927 |
Tgene | PPARG | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12700342 |
Tgene | PPARG | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 18293083 |
Tgene | PPARG | GO:0007165 | signal transduction | 9568716 |
Tgene | PPARG | GO:0010742 | macrophage derived foam cell differentiation | 26504087 |
Tgene | PPARG | GO:0010745 | negative regulation of macrophage derived foam cell differentiation | 19114110 |
Tgene | PPARG | GO:0010871 | negative regulation of receptor biosynthetic process | 12700342 |
Tgene | PPARG | GO:0010887 | negative regulation of cholesterol storage | 19114110 |
Tgene | PPARG | GO:0010891 | negative regulation of sequestering of triglyceride | 12700342 |
Tgene | PPARG | GO:0016525 | negative regulation of angiogenesis | 28566713 |
Tgene | PPARG | GO:0030224 | monocyte differentiation | 9568716 |
Tgene | PPARG | GO:0032526 | response to retinoic acid | 16239304 |
Tgene | PPARG | GO:0042953 | lipoprotein transport | 9568716 |
Tgene | PPARG | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 28566713 |
Tgene | PPARG | GO:0045713 | low-density lipoprotein particle receptor biosynthetic process | 9568716 |
Tgene | PPARG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9568715|12700342|16239304|17611579 |
Tgene | PPARG | GO:0048469 | cell maturation | 9568716 |
Tgene | PPARG | GO:0048662 | negative regulation of smooth muscle cell proliferation | 20622039 |
Tgene | PPARG | GO:0051091 | positive regulation of DNA binding transcription factor activity | 18293083 |
Tgene | PPARG | GO:0061614 | pri-miRNA transcription by RNA polymerase II | 28566713 |
Tgene | PPARG | GO:0071404 | cellular response to low-density lipoprotein particle stimulus | 9568716 |
Tgene | PPARG | GO:1904706 | negative regulation of vascular smooth muscle cell proliferation | 28522568 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BLCA | TCGA-E7-A4IJ-01A | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000314571 | ENST00000397010 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000314571 | ENST00000309576 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000314571 | ENST00000397015 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000314571 | ENST00000397012 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000314571 | ENST00000397026 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000314571 | ENST00000397000 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000314571 | ENST00000539812 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000314571 | ENST00000287820 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000383797 | ENST00000397010 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000383797 | ENST00000309576 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000383797 | ENST00000397015 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000383797 | ENST00000397012 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000383797 | ENST00000397026 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000383797 | ENST00000397000 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000383797 | ENST00000539812 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000383797 | ENST00000287820 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000454502 | ENST00000397010 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000454502 | ENST00000309576 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000454502 | ENST00000397015 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000454502 | ENST00000397012 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000454502 | ENST00000397026 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000454502 | ENST00000397000 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000454502 | ENST00000539812 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000454502 | ENST00000287820 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000402228 | ENST00000397010 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000402228 | ENST00000309576 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000402228 | ENST00000397015 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000402228 | ENST00000397012 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000402228 | ENST00000397026 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000402228 | ENST00000397000 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000402228 | ENST00000539812 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000402228 | ENST00000287820 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000444864 | ENST00000397010 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000444864 | ENST00000309576 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000444864 | ENST00000397015 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000444864 | ENST00000397012 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000444864 | ENST00000397026 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000444864 | ENST00000397000 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000444864 | ENST00000539812 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000444864 | ENST00000287820 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000284995 | ENST00000397010 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000284995 | ENST00000309576 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000284995 | ENST00000397015 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000284995 | ENST00000397012 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000284995 | ENST00000397026 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000284995 | ENST00000397000 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000284995 | ENST00000539812 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000284995 | ENST00000287820 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000415684 | ENST00000397010 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000415684 | ENST00000309576 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000415684 | ENST00000397015 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000415684 | ENST00000397012 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000415684 | ENST00000397026 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000415684 | ENST00000397000 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000415684 | ENST00000539812 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
5CDS-5UTR | ENST00000415684 | ENST00000287820 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
intron-5UTR | ENST00000475595 | ENST00000397010 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
intron-5UTR | ENST00000475595 | ENST00000309576 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
intron-5UTR | ENST00000475595 | ENST00000397015 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
intron-5UTR | ENST00000475595 | ENST00000397012 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
intron-5UTR | ENST00000475595 | ENST00000397026 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
intron-5UTR | ENST00000475595 | ENST00000397000 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
intron-5UTR | ENST00000475595 | ENST00000539812 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
intron-5UTR | ENST00000475595 | ENST00000287820 | TSEN2 | chr3 | 12560696 | + | PPARG | chr3 | 12421203 | + |
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FusionProtFeatures for TSEN2_PPARG |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TSEN2 | PPARG |
Constitutes one of the two catalytic subunit of thetRNA-splicing endonuclease complex, a complex responsible foridentification and cleavage of the splice sites in pre-tRNA. Itcleaves pre-tRNA at the 5'- and 3'-splice sites to release theintron. The products are an intron and two tRNA half-moleculesbearing 2',3'-cyclic phosphate and 5'-OH termini. There are noconserved sequences at the splice sites, but the intron isinvariably located at the same site in the gene, placing thesplice sites an invariant distance from the constant structuralfeatures of the tRNA body. Isoform 1 probably carries the activesite for 5'-splice site cleavage. The tRNA splicing endonucleaseis also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that theendonuclease subunits function in multiple RNA-processing events.Isoform 2 is responsible for processing a yet unknown RNAsubstrate. The complex containing isoform 2 is not able to cleavepre-tRNAs properly, although it retains endonucleolytic activity.{ECO:0000269|PubMed:15109492}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSEN2_PPARG |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSEN2_PPARG |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TSEN2 | TSEN34, TSEN54, TSEN15, CLP1, POLD1, POLD3, PRPF39, TBC1D2, TBC1D4, TRIP10, USP8, RTBDN, CLPB, PRELP, TUBB2B, ZNRF1, RAP1B, SORT1, VPS18, BAG6, GREB1L, TMED8, SFSWAP, XPC, TRIM25 | PPARG | NCOA4, GADD45G, DNTTIP2, PPARGC1A, HDAC3, HDAC4, RB1, EP300, EDF1, FABP1, NR0B2, SVIL, NRIP1, POU1F1, CREBBP, RXRA, MED24, MSX2, PML, ZBTB5, NR2E3, MAFF, ZBTB20, ZBTB3, ZNF496, ZBTB9, ZSCAN1, PIAS1, NCOR1, NCOR2, HMGA1, SP1, TFAP2A, CEBPB, MED1, ZNHIT3, TRIP4, JMJD1C, NFKBIB, SERPINH1, NCOA1, TRIM24, NCOA2, NCOA3, GRIP1, KAT5, LRIF1, HDAC1, MECP2, EZH2, NCOA6, NR0B1, COPS5, FHOD1, KIF1A, RXRB, ROBO4, KLF4, KDM4C, TNP1, KCTD13, RAD54L2, ANP32A, APP, RELA, UBC, CDC34, JAZF1, MED14, BCAS2, NEDD4, SMARCD3, SMARCA4, CDK5, MIF4GD, USP7, ALOX15B, SMAD2, ZFYVE9, NR3C1, MUC1, NSD1, PAXIP1, ASH2L, RBBP5, PRKAA1, PRKAA2, CTNNB1, SFPQ, NR4A1, NR4A2, JUN, NFE2L3, PHB2, STAT5A, VDR, RXRG, MAP2K1, CAV1, SMAD3, PDIA2, PPM1B, XRCC6, XRCC5, MAPK1, RANBP3, XPO1, JUND, LMO4, RFX5, CIITA, TCF4, NFKB1, PPARG, PRKCA, PIN1, STAT6, IKBKB, KAT2A, KIF11, CEP350, UBE2I, KLF5, IGFBP3, EGFR, MDM2, YWHAB, YWHAG, PPARGC1B, STAT1, STUB1, FLYWCH2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSEN2_PPARG |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | PPARG | P37231 | DB00244 | Mesalazine | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
Tgene | PPARG | P37231 | DB00573 | Fenoprofen | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
Tgene | PPARG | P37231 | DB00795 | Sulfasalazine | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
Tgene | PPARG | P37231 | DB01039 | Fenofibrate | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
Tgene | PPARG | P37231 | DB01050 | Ibuprofen | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
Tgene | PPARG | P37231 | DB13873 | Fenofibric acid | Peroxisome proliferator-activated receptor gamma | small molecule | approved |
Tgene | PPARG | P37231 | DB00313 | Valproic Acid | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB00328 | Indomethacin | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB00412 | Rosiglitazone | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB00731 | Nateglinide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB00912 | Repaglinide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB00966 | Telmisartan | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB01014 | Balsalazide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB01067 | Glipizide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB01118 | Amiodarone | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB01132 | Pioglitazone | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB01252 | Mitiglinide | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB01393 | Bezafibrate | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB08604 | Triclosan | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
Tgene | PPARG | P37231 | DB09213 | Dexibuprofen | Peroxisome proliferator-activated receptor gamma | small molecule | approved|investigational |
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RelatedDiseases for TSEN2_PPARG |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TSEN2 | C0011168 | Deglutition Disorders | 1 | CTD_human |
Hgene | TSEN2 | C0025958 | Microcephaly | 1 | CTD_human |
Hgene | TSEN2 | C0026650 | Movement Disorders | 1 | CTD_human |
Hgene | TSEN2 | C0042790 | Vision Disorders | 1 | CTD_human |
Hgene | TSEN2 | C0043094 | Weight Gain | 1 | CTD_human |
Hgene | TSEN2 | C2676466 | Pontocerebellar Hypoplasia Type 2B | 1 | CTD_human;UNIPROT |
Hgene | TSEN2 | C3714756 | Intellectual Disability | 1 | CTD_human |
Tgene | PPARG | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 5 | CTD_human |
Tgene | PPARG | C0011853 | Diabetes Mellitus, Experimental | 3 | CTD_human |
Tgene | PPARG | C0020538 | Hypertensive disease | 3 | CTD_human;HPO |
Tgene | PPARG | C0021655 | Insulin Resistance | 3 | CTD_human;HPO |
Tgene | PPARG | C0035126 | Reperfusion Injury | 3 | CTD_human |
Tgene | PPARG | C2609414 | Acute kidney injury | 3 | CTD_human |
Tgene | PPARG | C0002395 | Alzheimer's Disease | 2 | CTD_human |
Tgene | PPARG | C0021368 | Inflammation | 2 | CTD_human |
Tgene | PPARG | C0022116 | Ischemia | 2 | CTD_human |
Tgene | PPARG | C0028754 | Obesity | 2 | CTD_human;HPO;UNIPROT |
Tgene | PPARG | C0030297 | Pancreatic Neoplasm | 2 | CTD_human |
Tgene | PPARG | C0038356 | Stomach Neoplasms | 2 | CTD_human |
Tgene | PPARG | C1720861 | Familial Partial Lipodystrophy, Type 3 | 2 | ORPHANET;UNIPROT |
Tgene | PPARG | C0001418 | Adenocarcinoma | 1 | CTD_human |
Tgene | PPARG | C0004153 | Atherosclerosis | 1 | CTD_human |
Tgene | PPARG | C0004763 | Barrett Esophagus | 1 | CTD_human |
Tgene | PPARG | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | PPARG | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | PPARG | C0010346 | Crohn Disease | 1 | CTD_human |
Tgene | PPARG | C0011849 | Diabetes Mellitus | 1 | CTD_human;HPO |
Tgene | PPARG | C0017658 | Glomerulonephritis | 1 | CTD_human |
Tgene | PPARG | C0018801 | Heart failure | 1 | CTD_human |
Tgene | PPARG | C0023794 | Lipoidosis | 1 | CTD_human |
Tgene | PPARG | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | PPARG | C0025202 | melanoma | 1 | CTD_human |
Tgene | PPARG | C0025517 | Metabolic Diseases | 1 | CTD_human |
Tgene | PPARG | C0027746 | Nerve Degeneration | 1 | CTD_human |
Tgene | PPARG | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | PPARG | C0033860 | Psoriasis | 1 | CTD_human |
Tgene | PPARG | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | PPARG | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
Tgene | PPARG | C0079772 | T-Cell Lymphoma | 1 | CTD_human |
Tgene | PPARG | C0085413 | Polycystic Kidney, Autosomal Dominant | 1 | CTD_human |
Tgene | PPARG | C0221406 | Pituitary-dependent Cushing's disease | 1 | CTD_human |
Tgene | PPARG | C0236811 | Chronobiology Disorders | 1 | CTD_human |
Tgene | PPARG | C0242339 | Dyslipidemias | 1 | CTD_human |
Tgene | PPARG | C0242488 | Acute Lung Injury | 1 | CTD_human |
Tgene | PPARG | C0271694 | Familial partial lipodystrophy | 1 | CTD_human |
Tgene | PPARG | C0282548 | Leukostasis | 1 | CTD_human |
Tgene | PPARG | C0525045 | Mood Disorders | 1 | PSYGENET |
Tgene | PPARG | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | PPARG | C2931367 | Thyroid cancer, follicular | 1 | CTD_human |