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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39726

FusionGeneSummary for TSC22D2_ADCY5

check button Fusion gene summary
Fusion gene informationFusion gene name: TSC22D2_ADCY5
Fusion gene ID: 39726
HgeneTgene
Gene symbol

TSC22D2

ADCY5

Gene ID

9819

111

Gene nameTSC22 domain family member 2adenylate cyclase 5
SynonymsTILZ4a|TILZ4b|TILZ4cAC5|FDFM
Cytomap

3q25.1

3q21.1

Type of geneprotein-codingprotein-coding
DescriptionTSC22 domain family protein 2TSC22 domain family 2TSC22-related-inducible leucine zipper protein 4adenylate cyclase type 5ATP pyrophosphate-lyase 5adenylate cyclase type Vadenylyl cyclase 5
Modification date2018051920180523
UniProtAcc

O75157

O95622

Ensembl transtripts involved in fusion geneENST00000361136, ENST00000361875, 
ENST00000492828, 
ENST00000462833, 
ENST00000491190, ENST00000309879, 
ENST00000470367, 
Fusion gene scores* DoF score4 X 3 X 4=482 X 2 X 2=8
# samples 52
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(2/8*10)=1.32192809488736
Context

PubMed: TSC22D2 [Title/Abstract] AND ADCY5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneADCY5

GO:0006171

cAMP biosynthetic process

15385642|24700542

TgeneADCY5

GO:1904322

cellular response to forskolin

15385642|24700542


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-85-6175-01ATSC22D2chr3

150129095

+ADCY5chr3

123071428

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000361136ENST00000462833TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
Frame-shiftENST00000361136ENST00000491190TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
Frame-shiftENST00000361136ENST00000309879TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
5CDS-5UTRENST00000361136ENST00000470367TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
Frame-shiftENST00000361875ENST00000462833TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
Frame-shiftENST00000361875ENST00000491190TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
Frame-shiftENST00000361875ENST00000309879TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
5CDS-5UTRENST00000361875ENST00000470367TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
intron-3CDSENST00000492828ENST00000462833TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
intron-3CDSENST00000492828ENST00000491190TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
intron-3CDSENST00000492828ENST00000309879TSC22D2chr3

150129095

+ADCY5chr3

123071428

-
intron-5UTRENST00000492828ENST00000470367TSC22D2chr3

150129095

+ADCY5chr3

123071428

-

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FusionProtFeatures for TSC22D2_ADCY5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TSC22D2

O75157

ADCY5

O95622

Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642,PubMed:26206488, PubMed:24700542). Mediates signaling downstreamof ADRB1 (PubMed:24700542). Regulates the increase of freecytosolic Ca(2+) in response to increased blood glucose levels andcontributes to the regulation of Ca(2+)-dependent insulinsecretion (PubMed:24740569). {ECO:0000269|PubMed:15385642,ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569,ECO:0000269|PubMed:26206488}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TSC22D2_ADCY5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TSC22D2_ADCY5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TSC22D2KEAP1, TSC22D4, RNF2, WNK3, OSBPL1A, PSMA7, ZNF143, NRBP1, FLNB, LRRC6, MPDZ, REV1, TTN, WDR77, CCDC141, CCDC144A, KIAA0586, PRMT3, SNX3, SPEF2, TMA7, ANAPC10, ANKRD36, ARID2, ATP1B1, CLIP1, ENOPH1, EPCAM, F8, GPBP1, ITGA2, LOXHD1, LPL, MED13, MSH3, MTIF2, NGRN, PSMA8, RBL1, SAP18, SCEL, SEC31A, STK39, UFM1, ZMYM2, ZNF251, TSC22D3, FAM117BADCY5RGS2, GNAI1, ADCY5, ADCY2, CAV1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TSC22D2_ADCY5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneADCY5O95622DB09121AurothioglucoseAdenylate cyclase type 5small moleculeapproved|withdrawn

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RelatedDiseases for TSC22D2_ADCY5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneADCY5C0011570Mental Depression2PSYGENET
TgeneADCY5C0011581Depressive disorder2PSYGENET
TgeneADCY5C0011860Diabetes Mellitus, Non-Insulin-Dependent2CTD_human
TgeneADCY5C0878544Cardiomyopathies2CTD_human
TgeneADCY5C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneADCY5C0005612Birth Weight1CTD_human
TgeneADCY5C0016059Fibrosis1CTD_human
TgeneADCY5C0020538Hypertensive disease1CTD_human
TgeneADCY5C0024667Animal Mammary Neoplasms1CTD_human
TgeneADCY5C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneADCY5C0029456Osteoporosis1CTD_human
TgeneADCY5C0041696Unipolar Depression1PSYGENET
TgeneADCY5C0242698Ventricular Dysfunction, Left1CTD_human
TgeneADCY5C1269683Major Depressive Disorder1PSYGENET
TgeneADCY5C1847627Dyskinesia, Familial, with Facial Myokymia1ORPHANET;UNIPROT