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Fusion gene ID: 39726 |
FusionGeneSummary for TSC22D2_ADCY5 |
Fusion gene summary |
Fusion gene information | Fusion gene name: TSC22D2_ADCY5 | Fusion gene ID: 39726 | Hgene | Tgene | Gene symbol | TSC22D2 | ADCY5 | Gene ID | 9819 | 111 |
Gene name | TSC22 domain family member 2 | adenylate cyclase 5 | |
Synonyms | TILZ4a|TILZ4b|TILZ4c | AC5|FDFM | |
Cytomap | 3q25.1 | 3q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | TSC22 domain family protein 2TSC22 domain family 2TSC22-related-inducible leucine zipper protein 4 | adenylate cyclase type 5ATP pyrophosphate-lyase 5adenylate cyclase type Vadenylyl cyclase 5 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | O75157 | O95622 | |
Ensembl transtripts involved in fusion gene | ENST00000361136, ENST00000361875, ENST00000492828, | ENST00000462833, ENST00000491190, ENST00000309879, ENST00000470367, | |
Fusion gene scores | * DoF score | 4 X 3 X 4=48 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: TSC22D2 [Title/Abstract] AND ADCY5 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ADCY5 | GO:0006171 | cAMP biosynthetic process | 15385642|24700542 |
Tgene | ADCY5 | GO:1904322 | cellular response to forskolin | 15385642|24700542 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUSC | TCGA-85-6175-01A | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000361136 | ENST00000462833 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
Frame-shift | ENST00000361136 | ENST00000491190 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
Frame-shift | ENST00000361136 | ENST00000309879 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
5CDS-5UTR | ENST00000361136 | ENST00000470367 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
Frame-shift | ENST00000361875 | ENST00000462833 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
Frame-shift | ENST00000361875 | ENST00000491190 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
Frame-shift | ENST00000361875 | ENST00000309879 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
5CDS-5UTR | ENST00000361875 | ENST00000470367 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
intron-3CDS | ENST00000492828 | ENST00000462833 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
intron-3CDS | ENST00000492828 | ENST00000491190 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
intron-3CDS | ENST00000492828 | ENST00000309879 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
intron-5UTR | ENST00000492828 | ENST00000470367 | TSC22D2 | chr3 | 150129095 | + | ADCY5 | chr3 | 123071428 | - |
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FusionProtFeatures for TSC22D2_ADCY5 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
TSC22D2 | ADCY5 |
Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642,PubMed:26206488, PubMed:24700542). Mediates signaling downstreamof ADRB1 (PubMed:24700542). Regulates the increase of freecytosolic Ca(2+) in response to increased blood glucose levels andcontributes to the regulation of Ca(2+)-dependent insulinsecretion (PubMed:24740569). {ECO:0000269|PubMed:15385642,ECO:0000269|PubMed:24700542, ECO:0000269|PubMed:24740569,ECO:0000269|PubMed:26206488}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TSC22D2_ADCY5 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TSC22D2_ADCY5 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
TSC22D2 | KEAP1, TSC22D4, RNF2, WNK3, OSBPL1A, PSMA7, ZNF143, NRBP1, FLNB, LRRC6, MPDZ, REV1, TTN, WDR77, CCDC141, CCDC144A, KIAA0586, PRMT3, SNX3, SPEF2, TMA7, ANAPC10, ANKRD36, ARID2, ATP1B1, CLIP1, ENOPH1, EPCAM, F8, GPBP1, ITGA2, LOXHD1, LPL, MED13, MSH3, MTIF2, NGRN, PSMA8, RBL1, SAP18, SCEL, SEC31A, STK39, UFM1, ZMYM2, ZNF251, TSC22D3, FAM117B | ADCY5 | RGS2, GNAI1, ADCY5, ADCY2, CAV1 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TSC22D2_ADCY5 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | ADCY5 | O95622 | DB09121 | Aurothioglucose | Adenylate cyclase type 5 | small molecule | approved|withdrawn |
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RelatedDiseases for TSC22D2_ADCY5 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ADCY5 | C0011570 | Mental Depression | 2 | PSYGENET |
Tgene | ADCY5 | C0011581 | Depressive disorder | 2 | PSYGENET |
Tgene | ADCY5 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | CTD_human |
Tgene | ADCY5 | C0878544 | Cardiomyopathies | 2 | CTD_human |
Tgene | ADCY5 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Tgene | ADCY5 | C0005612 | Birth Weight | 1 | CTD_human |
Tgene | ADCY5 | C0016059 | Fibrosis | 1 | CTD_human |
Tgene | ADCY5 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | ADCY5 | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Tgene | ADCY5 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | ADCY5 | C0029456 | Osteoporosis | 1 | CTD_human |
Tgene | ADCY5 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | ADCY5 | C0242698 | Ventricular Dysfunction, Left | 1 | CTD_human |
Tgene | ADCY5 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |
Tgene | ADCY5 | C1847627 | Dyskinesia, Familial, with Facial Myokymia | 1 | ORPHANET;UNIPROT |