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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39706

FusionGeneSummary for TRUB1_FAM160B1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRUB1_FAM160B1
Fusion gene ID: 39706
HgeneTgene
Gene symbol

TRUB1

FAM160B1

Gene ID

142940

57700

Gene nameTruB pseudouridine synthase family member 1family with sequence similarity 160 member B1
SynonymsPUS4KIAA1600|bA106M7.3
Cytomap

10q25.3

10q25.3

Type of geneprotein-codingprotein-coding
Descriptionprobable tRNA pseudouridine synthase 1TruB pseudouridine (psi) synthase family member 1TruB pseudouridine (psi) synthase homolog 1protein FAM160B1
Modification date2018052320180519
UniProtAcc

Q8WWH5

Q5W0V3

Ensembl transtripts involved in fusion geneENST00000298746, ENST00000485065, 
ENST00000369250, ENST00000369248, 
ENST00000369246, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 5 X 2=50
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/50*10)=0
Context

PubMed: TRUB1 [Title/Abstract] AND FAM160B1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AT-01ATRUB1chr10

116719566

+FAM160B1chr10

116659253

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000298746ENST00000369250TRUB1chr10

116719566

+FAM160B1chr10

116659253

+
5CDS-intronENST00000298746ENST00000369248TRUB1chr10

116719566

+FAM160B1chr10

116659253

+
5CDS-intronENST00000298746ENST00000369246TRUB1chr10

116719566

+FAM160B1chr10

116659253

+
3UTR-3CDSENST00000485065ENST00000369250TRUB1chr10

116719566

+FAM160B1chr10

116659253

+
3UTR-intronENST00000485065ENST00000369248TRUB1chr10

116719566

+FAM160B1chr10

116659253

+
3UTR-intronENST00000485065ENST00000369246TRUB1chr10

116719566

+FAM160B1chr10

116659253

+

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FusionProtFeatures for TRUB1_FAM160B1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRUB1

Q8WWH5

FAM160B1

Q5W0V3

Pseudouridine synthase that catalyzes pseudouridylationof mRNAs (PubMed:28073919). Mediates pseudouridylation of mRNAswith the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loopstructure (PubMed:28073919). Constitutes the major pseudouridinesynthase acting on mRNAs (PubMed:28073919).{ECO:0000269|PubMed:28073919}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRUB1_FAM160B1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRUB1_FAM160B1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRUB1CAND1, APP, FBXO25, FLYWCH2, XPO1, SNW1, CDC5L, SLC2A2, MTFMT, USP11, TCEAL1FAM160B1ELAVL1, TNFSF13B, XPO1, KLHL2, POC5, PNKD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRUB1_FAM160B1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRUB1_FAM160B1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFAM160B1C0025202melanoma1CTD_human