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Fusion gene ID: 39705 |
FusionGeneSummary for TRRAP_TMEM168 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TRRAP_TMEM168 | Fusion gene ID: 39705 | Hgene | Tgene | Gene symbol | TRRAP | TMEM168 | Gene ID | 8295 | 64418 |
| Gene name | transformation/transcription domain associated protein | transmembrane protein 168 | |
| Synonyms | PAF350/400|PAF400|STAF40|TR-AP|Tra1 | - | |
| Cytomap | 7q22.1 | 7q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transformation/transcription domain-associated protein350/400 kDa PCAF-associated factortra1 homolog | transmembrane protein 168 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9Y4A5 | Q9H0V1 | |
| Ensembl transtripts involved in fusion gene | ENST00000355540, ENST00000359863, ENST00000446306, | ENST00000312814, ENST00000454074, ENST00000480969, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 2 X 2 X 2=8 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TRRAP [Title/Abstract] AND TMEM168 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TRRAP | GO:0016578 | histone deubiquitination | 18206972 |
| Hgene | TRRAP | GO:0043967 | histone H4 acetylation | 14966270 |
| Hgene | TRRAP | GO:0043968 | histone H2A acetylation | 14966270 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-78-7154-01A | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000355540 | ENST00000312814 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| 5CDS-5UTR | ENST00000355540 | ENST00000454074 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| 5CDS-intron | ENST00000355540 | ENST00000480969 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| 5CDS-5UTR | ENST00000359863 | ENST00000312814 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| 5CDS-5UTR | ENST00000359863 | ENST00000454074 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| 5CDS-intron | ENST00000359863 | ENST00000480969 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| 5CDS-5UTR | ENST00000446306 | ENST00000312814 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| 5CDS-5UTR | ENST00000446306 | ENST00000454074 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
| 5CDS-intron | ENST00000446306 | ENST00000480969 | TRRAP | chr7 | 98552927 | + | TMEM168 | chr7 | 112425008 | - |
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FusionProtFeatures for TRRAP_TMEM168 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TRRAP | TMEM168 |
| Adapter protein, which is found in various multiproteinchromatin complexes with histone acetyltransferase activity (HAT),which gives a specific tag for epigenetic transcriptionactivation. Component of the NuA4 histone acetyltransferasecomplex which is responsible for acetylation of nucleosomalhistones H4 and H2A. Plays a central role in MYC transcriptionactivation, and also participates in cell transformation by MYC.Required for p53/TP53-, E2F1- and E2F4-mediated transcriptionactivation. Also involved in transcription activation mediated bythe adenovirus E1A, a viral oncoprotein that deregulatestranscription of key genes. Probably acts by linking transcriptionfactors such as E1A, MYC or E2F1 to HAT complexes such as STAGAthereby allowing transcription activation. Probably not requiredin the steps following histone acetylation in processes oftranscription activation. May be required for the mitoticcheckpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histoneH2A.Z/H2AFZ from the nucleosome. {ECO:0000269|PubMed:11418595,ECO:0000269|PubMed:12138177, ECO:0000269|PubMed:12660246,ECO:0000269|PubMed:12743606, ECO:0000269|PubMed:14966270,ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:24463511,ECO:0000269|PubMed:9708738}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for TRRAP_TMEM168 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for TRRAP_TMEM168 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| TRRAP | MYC, MAX, KAT2A, E2F1, EP400, KAT2B, RUVBL1, ACTL6A, ING1, TAL1, SUPT3H, TAF9, ATXN7L3, USP22, ATXN7, ENY2, ING3, KAT5, OFD1, CTNNB1, TAF10, TTI1, TELO2, MRGBP, TP53, MED1, MED23, MED26, CDK8, MED12, MED13, MED14, MED15, MED16, MED17, MED24, MED25, E2F4, NPAT, USF1, C14orf169, MORF4L1, MORF4L2, SREBF1, CCDC101, DMAP1, PYGO2, ESR1, SIRT7, H2AFZ, SREBF2, ZNF148, CDKN1A, DCUN1D1, SKP1, CUL1, TCF3, TAF9B, TAF7, TAF4, MRE11A, CDC20, TAF5, TAF6, NPM1, DCP2, SOX3, OBSL1, EED, PLAC1, FOXR1, FOXR2, TADA1, TADA2B, TADA3, HIST1H2BA, YEATS4, USP7, BTAF1, VPS72, NCBP1, NCK1, MPHOSPH8, SUPT7L, RUVBL2, BRD8, EPC2, SUPT20H, TTI2, EPC1, KRT72, JAZF1, BRINP1, GAN, FOXO3, SENP3, NFATC1, NFATC2, MBTD1, AURKA, ATOH1, MYCL, MEAF6, SCN3B, STAT2, TAF6L, CACNG5, CREB3L1, HDAC6 | TMEM168 | SPP1, CRKL, NETO2, FAM174A, ATP2B2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for TRRAP_TMEM168 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRRAP_TMEM168 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | TRRAP | C0036341 | Schizophrenia | 2 | CTD_human |
| Hgene | TRRAP | C0025202 | melanoma | 1 | CTD_human |
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