FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 39655

FusionGeneSummary for TRPC1_PTPRG

check button Fusion gene summary
Fusion gene informationFusion gene name: TRPC1_PTPRG
Fusion gene ID: 39655
HgeneTgene
Gene symbol

TRPC1

PTPRG

Gene ID

7220

5793

Gene nametransient receptor potential cation channel subfamily C member 1protein tyrosine phosphatase, receptor type G
SynonymsHTRP-1|TRP1HPTPG|PTPG|R-PTP-GAMMA|RPTPG
Cytomap

3q23

3p14.2

Type of geneprotein-codingprotein-coding
Descriptionshort transient receptor potential channel 1TRP-1capacitative calcium channel protein Trp1transient receptor potential canonical 1transient receptor protein 1receptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-t
Modification date2018052720180527
UniProtAcc

P48995

P23470

Ensembl transtripts involved in fusion geneENST00000476941, ENST00000273482, 
ENST00000295874, ENST00000474889, 
ENST00000495879, 
Fusion gene scores* DoF score1 X 1 X 1=18 X 6 X 5=240
# samples 18
** MAII scorelog2(1/1*10)=3.32192809488736log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRPC1 [Title/Abstract] AND PTPRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTRPC1

GO:0042438

melanin biosynthetic process

8126111

HgeneTRPC1

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

19052258

HgeneTRPC1

GO:0051480

regulation of cytosolic calcium ion concentration

19052258

HgeneTRPC1

GO:0051592

response to calcium ion

14505576|19052258


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-BP-4963-01ATRPC1chr3

142467302

+PTPRGchr3

61734552

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000476941ENST00000295874TRPC1chr3

142467302

+PTPRGchr3

61734552

+
Frame-shitENST00000476941ENST00000474889TRPC1chr3

142467302

+PTPRGchr3

61734552

+
5CDS-3UTRENST00000476941ENST00000495879TRPC1chr3

142467302

+PTPRGchr3

61734552

+
Frame-shitENST00000273482ENST00000295874TRPC1chr3

142467302

+PTPRGchr3

61734552

+
Frame-shitENST00000273482ENST00000474889TRPC1chr3

142467302

+PTPRGchr3

61734552

+
5CDS-3UTRENST00000273482ENST00000495879TRPC1chr3

142467302

+PTPRGchr3

61734552

+

Top

FusionProtFeatures for TRPC1_PTPRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRPC1

P48995

PTPRG

P23470

Thought to form a receptor-activated non-selectivecalcium permeant cation channel. Probably is operated by aphosphatidylinositol second messenger system activated by receptortyrosine kinases or G-protein coupled receptors. Seems to be alsoactivated by intracellular calcium store depletion.{ECO:0000269|PubMed:15016832}. Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for TRPC1_PTPRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for TRPC1_PTPRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRPC1PKD2, GRM1, HOMER1, HOMER3, ITPR1, TRPC6, TRPC3, TRPC4, TRPC5, RHOA, TRPC1, ITPR3, CAV1, ELAVL1, TRPC4AP, TNFRSF1APTPRGDLG4, PTPRG, LGALS8, FYTTD1, FCN1, TMEM185A, CCNL2, DUSP26, PTPRB, SEC24A, FCHO2, CEP89, CDC42BPB, FAM129B, PSD3, PALM, CASKIN2, HSPA12A, GPRIN1, NF2, RPS15, CLNS1A, SLC39A10, ADD2, FARP1, GJB7, SDC1, DUS4L, MED21, PCDHGC3, DUSP22, ISG20, SERPINA12, ZNF517, ACBD7, NCSTN, NPB, SCGB2A2, CLCC1, DUSP23, DEFB104A, IER3IP1, PACS1, PTPRA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for TRPC1_PTPRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for TRPC1_PTPRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRPC1C0018800Cardiomegaly1CTD_human
TgenePTPRGC0038356Stomach Neoplasms1CTD_human