|
Fusion gene ID: 396 |
FusionGeneSummary for ACLY_DNAJC7 |
Fusion gene summary |
Fusion gene information | Fusion gene name: ACLY_DNAJC7 | Fusion gene ID: 396 | Hgene | Tgene | Gene symbol | ACLY | DNAJC7 | Gene ID | 47 | 7266 |
Gene name | ATP citrate lyase | DnaJ heat shock protein family (Hsp40) member C7 | |
Synonyms | ACL|ATPCL|CLATP | DJ11|DJC7|TPR2|TTC2 | |
Cytomap | 17q21.2 | 17q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP-citrate synthaseATP-citrate (pro-S-)-lyasecitrate cleavage enzyme | dnaJ homolog subfamily C member 7DnaJ (Hsp40) homolog, subfamily C, member 7TPR repeat protein 2tetratricopeptide repeat domain 2tetratricopeptide repeat protein 2 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | P53396 | Q99615 | |
Ensembl transtripts involved in fusion gene | ENST00000352035, ENST00000590151, ENST00000353196, ENST00000537919, ENST00000393896, ENST00000588779, | ENST00000457167, ENST00000426588, ENST00000316603, ENST00000589547, | |
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 5 X 5 X 5=125 |
# samples | 5 | 6 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/125*10)=-1.05889368905357 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ACLY [Title/Abstract] AND DNAJC7 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ACLY | GO:0006085 | acetyl-CoA biosynthetic process | 1371749 |
Hgene | ACLY | GO:0006101 | citrate metabolic process | 1371749 |
Hgene | ACLY | GO:0006107 | oxaloacetate metabolic process | 1371749 |
Hgene | ACLY | GO:0008610 | lipid biosynthetic process | 23932781 |
Tgene | DNAJC7 | GO:0051085 | chaperone cofactor-dependent protein refolding | 12853476|18620420 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-D8-A1JM-01A | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
TCGA | RV | BRCA | TCGA-LL-A6FR-01A | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000352035 | ENST00000457167 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000352035 | ENST00000426588 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000352035 | ENST00000316603 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000352035 | ENST00000589547 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000590151 | ENST00000457167 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000590151 | ENST00000426588 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000590151 | ENST00000316603 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000590151 | ENST00000589547 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000353196 | ENST00000457167 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000353196 | ENST00000426588 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000353196 | ENST00000316603 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000353196 | ENST00000589547 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000537919 | ENST00000457167 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000537919 | ENST00000426588 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000537919 | ENST00000316603 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000537919 | ENST00000589547 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000393896 | ENST00000457167 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000393896 | ENST00000426588 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000393896 | ENST00000316603 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000393896 | ENST00000589547 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
intron-3CDS | ENST00000588779 | ENST00000457167 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
intron-3CDS | ENST00000588779 | ENST00000426588 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
intron-3CDS | ENST00000588779 | ENST00000316603 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
intron-intron | ENST00000588779 | ENST00000589547 | ACLY | chr17 | 40054884 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000352035 | ENST00000457167 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000352035 | ENST00000426588 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000352035 | ENST00000316603 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000352035 | ENST00000589547 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000590151 | ENST00000457167 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000590151 | ENST00000426588 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000590151 | ENST00000316603 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000590151 | ENST00000589547 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000353196 | ENST00000457167 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000353196 | ENST00000426588 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000353196 | ENST00000316603 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000353196 | ENST00000589547 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000537919 | ENST00000457167 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000537919 | ENST00000426588 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
In-frame | ENST00000537919 | ENST00000316603 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000537919 | ENST00000589547 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000393896 | ENST00000457167 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000393896 | ENST00000426588 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
Frame-shift | ENST00000393896 | ENST00000316603 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
5CDS-intron | ENST00000393896 | ENST00000589547 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
intron-3CDS | ENST00000588779 | ENST00000457167 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
intron-3CDS | ENST00000588779 | ENST00000426588 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
intron-3CDS | ENST00000588779 | ENST00000316603 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
intron-intron | ENST00000588779 | ENST00000589547 | ACLY | chr17 | 40057949 | - | DNAJC7 | chr17 | 40129341 | - |
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FusionProtFeatures for ACLY_DNAJC7 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ACLY | DNAJC7 |
ATP-citrate synthase is the primary enzyme responsiblefor the synthesis of cytosolic acetyl-CoA in many tissues. Has acentral role in de novo lipid synthesis. In nervous tissue it maybe involved in the biosynthesis of acetylcholine.{ECO:0000269|PubMed:23932781}. | Acts as co-chaperone regulating the molecular chaperonesHSP70 and HSP90 in folding of steroid receptors, such as theglucocorticoid receptor and the progesterone receptor. Proposed toact as a recycling chaperone by facilitating the return ofchaperone substrates to early stages of chaperoning if furtherfolding is required. In vitro, induces ATP-independentdissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:12853476,ECO:0000269|PubMed:18620420}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000352035 | - | 11 | 29 | 4_265 | 394 | 1102 | Domain | Note=ATP-grasp |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000353196 | - | 11 | 28 | 4_265 | 394 | 1092 | Domain | Note=ATP-grasp |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000393896 | - | 11 | 28 | 4_265 | 394 | 1092 | Domain | Note=ATP-grasp |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000590151 | - | 11 | 29 | 4_265 | 394 | 1102 | Domain | Note=ATP-grasp |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000352035 | - | 11 | 29 | 109_111 | 394 | 1102 | Nucleotide binding | Note=ATP |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000352035 | - | 11 | 29 | 66_67 | 394 | 1102 | Nucleotide binding | Note=ATP |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000353196 | - | 11 | 28 | 109_111 | 394 | 1092 | Nucleotide binding | Note=ATP |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000353196 | - | 11 | 28 | 66_67 | 394 | 1092 | Nucleotide binding | Note=ATP |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000393896 | - | 11 | 28 | 109_111 | 394 | 1092 | Nucleotide binding | Note=ATP |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000393896 | - | 11 | 28 | 66_67 | 394 | 1092 | Nucleotide binding | Note=ATP |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000590151 | - | 11 | 29 | 109_111 | 394 | 1102 | Nucleotide binding | Note=ATP |
Hgene | ACLY | chr17:40057949 | chr17:40129341 | ENST00000590151 | - | 11 | 29 | 66_67 | 394 | 1102 | Nucleotide binding | Note=ATP |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000352035 | - | 11 | 29 | 701_721 | 394 | 1102 | Nucleotide binding | ATP |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000352035 | - | 11 | 29 | 752_778 | 394 | 1102 | Nucleotide binding | ATP |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000353196 | - | 11 | 28 | 701_721 | 394 | 1092 | Nucleotide binding | ATP |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000353196 | - | 11 | 28 | 752_778 | 394 | 1092 | Nucleotide binding | ATP |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000393896 | - | 11 | 28 | 701_721 | 394 | 1092 | Nucleotide binding | ATP |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000393896 | - | 11 | 28 | 752_778 | 394 | 1092 | Nucleotide binding | ATP |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000590151 | - | 11 | 29 | 701_721 | 394 | 1102 | Nucleotide binding | ATP |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000590151 | - | 11 | 29 | 752_778 | 394 | 1102 | Nucleotide binding | ATP |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000352035 | - | 11 | 29 | 779_789 | 394 | 1102 | Region | CoA-binding |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000353196 | - | 11 | 28 | 779_789 | 394 | 1092 | Region | CoA-binding |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000393896 | - | 11 | 28 | 779_789 | 394 | 1092 | Region | CoA-binding |
Hgene | >ACLY | chr17:40057949 | chr17:40129341 | ENST00000590151 | - | 11 | 29 | 779_789 | 394 | 1102 | Region | CoA-binding |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 381_451 | 405 | 439 | Domain | J |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 381_451 | 405 | 439 | Domain | J |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 381_451 | 461 | 495 | Domain | J |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 142_175 | 405 | 439 | Repeat | Note=TPR 4 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 177_209 | 405 | 439 | Repeat | Note=TPR 5 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 210_243 | 405 | 439 | Repeat | Note=TPR 6 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 256_289 | 405 | 439 | Repeat | Note=TPR 7 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 28_61 | 405 | 439 | Repeat | Note=TPR 1 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 294_327 | 405 | 439 | Repeat | Note=TPR 8 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 328_361 | 405 | 439 | Repeat | Note=TPR 9 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 62_95 | 405 | 439 | Repeat | Note=TPR 2 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000316603 | - | 10 | 13 | 96_129 | 405 | 439 | Repeat | Note=TPR 3 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 142_175 | 405 | 439 | Repeat | Note=TPR 4 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 177_209 | 405 | 439 | Repeat | Note=TPR 5 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 210_243 | 405 | 439 | Repeat | Note=TPR 6 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 256_289 | 405 | 439 | Repeat | Note=TPR 7 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 28_61 | 405 | 439 | Repeat | Note=TPR 1 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 294_327 | 405 | 439 | Repeat | Note=TPR 8 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 328_361 | 405 | 439 | Repeat | Note=TPR 9 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 62_95 | 405 | 439 | Repeat | Note=TPR 2 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000426588 | - | 11 | 14 | 96_129 | 405 | 439 | Repeat | Note=TPR 3 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 142_175 | 461 | 495 | Repeat | Note=TPR 4 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 177_209 | 461 | 495 | Repeat | Note=TPR 5 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 210_243 | 461 | 495 | Repeat | Note=TPR 6 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 256_289 | 461 | 495 | Repeat | Note=TPR 7 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 28_61 | 461 | 495 | Repeat | Note=TPR 1 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 294_327 | 461 | 495 | Repeat | Note=TPR 8 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 328_361 | 461 | 495 | Repeat | Note=TPR 9 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 62_95 | 461 | 495 | Repeat | Note=TPR 2 |
Tgene | DNAJC7 | chr17:40057949 | chr17:40129341 | ENST00000457167 | - | 11 | 14 | 96_129 | 461 | 495 | Repeat | Note=TPR 3 |
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FusionGeneSequence for ACLY_DNAJC7 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ACLY_DNAJC7 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ACLY | TFE3, IKBKE, PRKAB1, GSK3B, NME2, HGS, TERF1, TERF2, HDAC5, SIRT7, ISG15, CUL3, CUL2, CAND1, SHC1, APP, UBC, FN1, CDKN2A, BAG3, KPNA2, KPNA4, PPP6C, PRMT1, SRRT, MAGED2, MCM2, MCM6, NCL, WWOX, ASB15, TRIM25, STAU1, HUWE1, UBR4, KAT2B, SIRT2, CUL7, OBSL1, CCDC8, SIRT6, CTH, EEF1D, PYGB, CS, HNRNPK, NAPRT, NUP210L, RPE, SDHA, SDHB, STIP1, NTRK1, AHSA1, NUP107, ATF6, CRY1, CRY2, FBXW7, USP13, DERL1, ZNF746, DDIAS, DUSP13, DNM1L, BRCA1 | DNAJC7 | RAD9A, HUS1, RAD1, ATG2A, MKNK1, DISC1, FBXO25, CUL3, HSP90AA1, NR3C1, NR3C2, PGR, AR, HSPA4, PTGES3, LMAN1, TP53BP1, NOS2, SMAD9, SMAD2, ITGA4, HSPA1A, HSPA8, NRD1, TPM1, BAG4, CDC37, HSPA1L, TP53, SPRTN, CUL7, ABCE1, RPS6KB2, FBXW11, FUS, HNRNPD, HSPA5, HYOU1, NAA50, TOMM34, NTRK1, SCLT1, OFD1, MKS1, KIAA0753, NPHP4, EVC2, RPGR, CAD, CLTA, CLTC, CPS1, EIF2S3, FASN, GART, GNAS, HSPA2, HSP90AB1, DNAJB1, PFAS, POLR2B, PRKDC, RNF5, SVIL, CCT3, BAG2, CLINT1, KIAA0100, STUB1, STIP1, DNAJB4, SYNPO, TRIM32, VPS13A, MAU2, HERC4, VPS13C, IFT122, TDRD9, MISP, VPS13B, LAMA1, CRY2, MCM2, OTUB1, NFATC1, PTPN18, EML5, BBS10, NPHP1, FANCB, URGCP, WDR41, GREB1, C5orf34, WDR19, MTO1, CTC1, PLD2, NEURL4, MOCOS, IFT172, PWP2, SMG8, POLE, LCMT2, WDR35, WDR62, DNA2, ESPL1, IFT140, FUNDC2, LRWD1, MED16, POLE2, KIF20B, USP19, ESR1, TXNIP |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ACLY_DNAJC7 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ACLY_DNAJC7 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ACLY | C0018801 | Heart failure | 1 | CTD_human |
Hgene | ACLY | C0028754 | Obesity | 1 | CTD_human |
Hgene | ACLY | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | DNAJC7 | C0019693 | HIV Infections | 1 | CTD_human |