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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 39575

FusionGeneSummary for TRIO_ATAD1

check button Fusion gene summary
Fusion gene informationFusion gene name: TRIO_ATAD1
Fusion gene ID: 39575
HgeneTgene
Gene symbol

TRIO

ATAD1

Gene ID

7204

84896

Gene nametrio Rho guanine nucleotide exchange factorATPase family, AAA domain containing 1
SynonymsARHGEF23|MEBAS|MRD44|tgatAFDC1|FNP001|THORASE
Cytomap

5p15.2

10q23.31

Type of geneprotein-codingprotein-coding
Descriptiontriple functional domain proteinPTPRF-interacting proteintriple functional domain (PTPRF interacting)ATPase family AAA domain-containing protein 1
Modification date2018052720180522
UniProtAcc

O75962

Q8NBU5

Ensembl transtripts involved in fusion geneENST00000344204, ENST00000537187, 
ENST00000509967, ENST00000515710, 
ENST00000344135, 		ENST00000308448, 
ENST00000328142, ENST00000400215, 
ENST00000541004, ENST00000495903, 
Fusion gene scores* DoF score26 X 18 X 10=468013 X 5 X 7=455
# samples 2714
** MAII scorelog2(27/4680*10)=-4.11547721741994
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/455*10)=-1.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TRIO [Title/Abstract] AND ATAD1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-EJ-5495-01ATRIOchr5

14381361

+ATAD1chr10

89574369

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000344204ENST00000308448TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000344204ENST00000328142TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-intronENST00000344204ENST00000400215TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000344204ENST00000541004TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000344204ENST00000495903TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000537187ENST00000308448TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000537187ENST00000328142TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-intronENST00000537187ENST00000400215TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000537187ENST00000541004TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000537187ENST00000495903TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000509967ENST00000308448TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000509967ENST00000328142TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-intronENST00000509967ENST00000400215TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000509967ENST00000541004TRIOchr5

14381361

+ATAD1chr10

89574369

-
5CDS-5UTRENST00000509967ENST00000495903TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-5UTRENST00000515710ENST00000308448TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-5UTRENST00000515710ENST00000328142TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-intronENST00000515710ENST00000400215TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-5UTRENST00000515710ENST00000541004TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-5UTRENST00000515710ENST00000495903TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-5UTRENST00000344135ENST00000308448TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-5UTRENST00000344135ENST00000328142TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-intronENST00000344135ENST00000400215TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-5UTRENST00000344135ENST00000541004TRIOchr5

14381361

+ATAD1chr10

89574369

-
intron-5UTRENST00000344135ENST00000495903TRIOchr5

14381361

+ATAD1chr10

89574369

-

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FusionProtFeatures for TRIO_ATAD1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TRIO

O75962

ATAD1

Q8NBU5

Guanine nucleotide exchange factor (GEF) for RHOA andRAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved incoordinating actin remodeling, which is necessary for cellmigration and growth (PubMed:10341202). In developing hippocampalneurons, limits dendrite formation, without affecting theestablishment of axon polarity. Once dendrites are formed,involved in the control of synaptic function by regulating theendocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1excitatory synapses (By similarity). May act as a regulator ofadipogenesis (By similarity). {ECO:0000250|UniProtKB:F1M0Z1,ECO:0000269|PubMed:10341202, ECO:0000269|PubMed:27418539,ECO:0000269|PubMed:8643598}. ATPase that plays a critical role in regulating thesurface expression of AMPA receptors (AMPAR), thereby regulatingsynaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2recycling back to the plasma membrane; these activities areATPase-dependent (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for TRIO_ATAD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for TRIO_ATAD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TRIOFLNA, BLMH, RAC1, PTPRF, RHOA, CDC5L, DISC1, EXOC1, ITSN2, BCAS2, DAB2, NAV1, NAV2, NAV3, RHOG, MAPRE1, NTRK1, CFAP45, PPM1F, RPE, SSU72, CENPJ, MYC, ZSCAN26, PTPRD, PTPRS, ZNF232, ZNF785, TRIM25ATAD1USP19, BABAM1, ELAVL1, PEX14, EGFR, BSCL2, FAF2, GOSR1, REV3L, VAPA, COQ9, NDUFA4, OCIAD1, TPM2, MAS1, ANKS6


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TRIO_ATAD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for TRIO_ATAD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneTRIOC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneTRIOC0023903Liver neoplasms1CTD_human
HgeneTRIOC0032927Precancerous Conditions1CTD_human